Pathological evaluation for advanced colorectal cancer aiming at treatment proposal for molecular targeted drugs

Research Project

Project/Area Number	25430136
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Tumor diagnostics
Research Institution	Osaka Medical College
Principal Investigator	Hirose Yoshinobu 大阪医科大学, 医学部, 教授 (20293574)
Project Period (FY)	2013-04-01 – 2017-03-31
Project Status	Completed (Fiscal Year 2016)
Budget Amount *help	¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000) Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords	大腸癌 / 分子標的薬 / 病理評価 / EGFR / HER3 / 腫瘍内不均一性 / 進行大腸癌 / BRAF / HER2 / 病理解析 / 治療提案
Outline of Final Research Achievements	Comparative studies of immunostaining of EGFR and HER3 in advanced colorectal cancer showed that the expression pattern of HER3 at the invasive margin tended to be opposite to that of EGFR. Pathological assessment of immunostaining requires careful consideration of the heterogeneity within the tumor, otherwise it may not accurately reflect the biological properties of tumors and hence the therapeutic effect.

Report

(5 results)