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Search for new urothelial cancer biomarkers

Research Project

Project/Area Number 25430140
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Tumor diagnostics
Research InstitutionJuntendo University

Principal Investigator

TAKA HIKARI  順天堂大学, 医学(系)研究科(研究院), 助教 (60338374)

Co-Investigator(Kenkyū-buntansha) FUJIMURA Tsutomu  東北医科薬科大学, 薬学部, 教授 (70245778)
Co-Investigator(Renkei-kenkyūsha) SAITO Seiichi  琉球大学, 医学部, 教授 (80235043)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords尿中腫瘍マーカー / 糖タンパク質 / ウエスタンブロット / ELISA / 膀胱がん / 糖タンパク質抗体 / 膀胱癌 / 糖鎖修飾ペプチド抗体 / ストレプトアビジンーフィコエリスリン / 早期発見・診断 / 糖鎖修飾ペプチド / 膀胱がんの早期発見・診断
Outline of Final Research Achievements

Biomarkers from sample of serum or urine have the advantage of being less of a burden to the patients. Currently the most effective biomarker for bladder cancer is NMP22. However, NMP22 has the problem of presenting a very high rate of false positive. In this study, we examined for a new diagnostic biomarker to complement NMP22 using urine from bladder cancer patients in order to attempt early detection of bladder cancer. Protein bands detected at 75kDa (glycoprotein X) and 50kDa (glycoprotein Y) reacted strongly to SNA lectin in the urine of patients with bladder cancer. The stronger reactivity was correlated with an increase in malignancy. The sugar chains of glycoprotein X and Y are suggested the possibility as a novel biomarker which complement NMP22. Analysis of sugar chains of glycoprotein X and Y in urine will be useful tool for early diagnosis of bladder cancer.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (14 results)

All 2015 2014 2013

All Journal Article (8 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 8 results,  Open Access: 6 results) Presentation (5 results) Book (1 results)

  • [Journal Article] Absence of Elovl6 attenuates steatohepatitis but promotes gallstone formation in a2015

    • Author(s)
      Kuba M, Matsuzaka T, Matsumori R, Saito R, Kaga N, Taka H, Ikehata K, Okada N,
    • Journal Title

      Sci Rep.

      Volume: 5 Issue: 1 Pages: 17604-17604

    • DOI

      10.1038/srep17604

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Secreted tyrosine sulfated-eIF5A mediates oxidative stress-induced apoptosis.2015

    • Author(s)
      Seko Y, Fujimura T, Yao T, Taka H, Mineki R, Okumura K, Murayama K.
    • Journal Title

      Sci Rep.

      Volume: 8;5 Issue: 1 Pages: 13737-13751

    • DOI

      10.1038/srep13737

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A clinically attainable dose of L-asparaginase targets2015

    • Author(s)
      Sugimoto K, Suzuki HI, Fujimura T, Ono A, Kaga N, Isobe Y, Sasaki M, Taka H,
    • Journal Title

      Cancer Sci.

      Volume: 106 Issue: 11 Pages: 1534-1543

    • DOI

      10.1111/cas.12807

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of sitagliptin on ectopic fat contents and glucose metabolism in type 2 diabetic patients with fatty liver: A pilot study2014

    • Author(s)
      Watanabe T, Tamura Y, Kakehi S, Funayama T, Takeno K, Kawaguchi M, Yamamoto L, Sato F, Ikeda S, Taka H, Fujimura T, Fujitani Y, Kawamori R, Watada H
    • Journal Title

      J Diabetes Invest

      Volume: Mar;6(2) Issue: 2 Pages: 164-72

    • DOI

      10.1111/jdi.12262

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Increased expression of ERp57/GRP58 is protective against pancreatic beta cell death caused by autophagic failure.2014

    • Author(s)
      Yamamoto E, Uchida T, Abe H, Taka H, Fujimura T, Komiya K, Hara A, Ogihara T, Fujitani Y, Ueno T, Takeda S, Watada H.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 453 Issue: 1 Pages: 19-24

    • DOI

      10.1016/j.bbrc.2014.09.040

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A treadmill exercise reactivates the signaling of the mammalian target of rapamycin (mTor) in the skeletal muscles of starved mice.2014

    • Author(s)
      Zheng, D.M., Bian, Z., Furuya, N., Oliva Trejo, J.A., Takeda-Ezaki, M., Takahashi, K., Hiraoka, Y., Mineki, R., Taka, H., Ikeda, S., Komatsu, M., Fujimura, T., Ueno, T., Ezaki, J.
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 456 Issue: 1 Pages: 519-526

    • DOI

      10.1016/j.bbrc.2014.11.118

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sialyl-glycoconjugates in cholesterol-rich microdomains of P388 cells are the triggers for apoptosis induced by Rana catesbeiana oocyte ribonuclease.2014

    • Author(s)
      Ogawa Y, Fujimura T, Ozeki Y, et al.
    • Journal Title

      Glycoconj J.

      Volume: 31 Issue: 2 Pages: 171-84

    • DOI

      10.1007/s10719-013-9513-7

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Lysine and arginine biosyntheses mediated by a common carrier protein in Sulfolobus.2013

    • Author(s)
      Ouchi T, Fujimura T, et al.
    • Journal Title

      Nat Chem Biol.

      Volume: 9(4):277-83 Issue: 4 Pages: 277-283

    • DOI

      10.1038/nchembio.1200

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 妊娠中の摂取カロリー制限母ラットからの出生仔でみられたグルココルチコイドフィードバックの異常と次世代仔への影響2015

    • Author(s)
      根本 崇宏、藤村 務、加賀 直子、高 ひかり、上野 隆、柿沼 吉彦
    • Organizer
      BMB2015
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] 胎生期低栄養が引き起こす血中代謝物の変動解析2015

    • Author(s)
      加賀 直子、高 ひかり、根本 崇宏、藤村 務、上野 隆
    • Organizer
      第9回メタボロームシンポジウム2015
    • Place of Presentation
      三島市民文化会館/三島商工会議所
    • Year and Date
      2015-09-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] Search of cancer markers in exhaled breath.2014

    • Author(s)
      Fujimura T, Matsumori S , Kaga K, Taka H, Kajiyama Y, Ueno T
    • Organizer
      Metabolomics 2014
    • Place of Presentation
      山形県鶴岡市 鶴岡第一ホテル・MARICA
    • Year and Date
      2014-06-23 – 2014-06-26
    • Related Report
      2014 Research-status Report
  • [Presentation] 呼気中のがんマーカーの探索2013

    • Author(s)
      藤村 務、加賀 直子、松森 聖、梶山 美明、高 ひかり、上野 隆
    • Organizer
      がんと代謝研究会
    • Place of Presentation
      山形県 鶴岡メタボロームキャンパス レクチャーホール
    • Related Report
      2013 Research-status Report
  • [Presentation] Search of New Urothelial Cancer Biomarkers2013

    • Author(s)
      Tsutomu Fujimura, Hikari Taka, Saiko Kazuno, Reiko Mineki, Kimie Murayama, Takashi Ueno, Jun-ichi Furukawa, Yasuro Shinohara
    • Organizer
      HUPO
    • Place of Presentation
      神奈川県 パシフィコ横浜
    • Related Report
      2013 Research-status Report
  • [Book] 腎臓病実験法ハンドブック2013

    • Author(s)
      富野 康日己、藤村 務、高 ひかり、他
    • Total Pages
      238
    • Publisher
      中外医学社
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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