Search for new urothelial cancer biomarkers
| Project/Area Number |
25430140
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Tumor diagnostics
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| Research Institution | Juntendo University |
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Principal Investigator |
TAKA HIKARI 順天堂大学, 医学(系)研究科(研究院), 助教 (60338374)
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| Co-Investigator(Kenkyū-buntansha) |
FUJIMURA Tsutomu 東北医科薬科大学, 薬学部, 教授 (70245778)
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| Co-Investigator(Renkei-kenkyūsha) |
SAITO Seiichi 琉球大学, 医学部, 教授 (80235043)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 尿中腫瘍マーカー / 糖タンパク質 / ウエスタンブロット / ELISA / 膀胱がん / 糖タンパク質抗体 / 膀胱癌 / 糖鎖修飾ペプチド抗体 / ストレプトアビジンーフィコエリスリン / 早期発見・診断 / 糖鎖修飾ペプチド / 膀胱がんの早期発見・診断 |
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| Outline of Final Research Achievements |
Biomarkers from sample of serum or urine have the advantage of being less of a burden to the patients. Currently the most effective biomarker for bladder cancer is NMP22. However, NMP22 has the problem of presenting a very high rate of false positive. In this study, we examined for a new diagnostic biomarker to complement NMP22 using urine from bladder cancer patients in order to attempt early detection of bladder cancer. Protein bands detected at 75kDa (glycoprotein X) and 50kDa (glycoprotein Y) reacted strongly to SNA lectin in the urine of patients with bladder cancer. The stronger reactivity was correlated with an increase in malignancy. The sugar chains of glycoprotein X and Y are suggested the possibility as a novel biomarker which complement NMP22. Analysis of sugar chains of glycoprotein X and Y in urine will be useful tool for early diagnosis of bladder cancer.
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Report
(4 results)
Research Products
(14 results)
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[Journal Article] Effects of sitagliptin on ectopic fat contents and glucose metabolism in type 2 diabetic patients with fatty liver: A pilot study2014
Author(s)
Watanabe T, Tamura Y, Kakehi S, Funayama T, Takeno K, Kawaguchi M, Yamamoto L, Sato F, Ikeda S, Taka H, Fujimura T, Fujitani Y, Kawamori R, Watada H
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Journal Title
J Diabetes Invest
Volume: Mar;6(2)
Issue: 2
Pages: 164-72
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Increased expression of ERp57/GRP58 is protective against pancreatic beta cell death caused by autophagic failure.2014
Author(s)
Yamamoto E, Uchida T, Abe H, Taka H, Fujimura T, Komiya K, Hara A, Ogihara T, Fujitani Y, Ueno T, Takeda S, Watada H.
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Journal Title
Biochem Biophys Res Commun
Volume: 453
Issue: 1
Pages: 19-24
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] A treadmill exercise reactivates the signaling of the mammalian target of rapamycin (mTor) in the skeletal muscles of starved mice.2014
Author(s)
Zheng, D.M., Bian, Z., Furuya, N., Oliva Trejo, J.A., Takeda-Ezaki, M., Takahashi, K., Hiraoka, Y., Mineki, R., Taka, H., Ikeda, S., Komatsu, M., Fujimura, T., Ueno, T., Ezaki, J.
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Journal Title
Biochem. Biophys. Res. Commun.
Volume: 456
Issue: 1
Pages: 519-526
DOI
Related Report
Peer Reviewed / Open Access
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