Development of novel pancreatic cancer diagnostic and therapeutic method targeting Annexin A8
| Project/Area Number |
25430141
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Tumor diagnostics
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| Research Institution | Nihon University (2016)
Showa University (2013-2015) |
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Principal Investigator |
HATA Harumi 日本大学, 薬学部, 准教授 (00396441)
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| Co-Investigator(Kenkyū-buntansha) |
立道 昌幸 東海大学, 医学部, 教授 (00318263)
小林 秀昭 帝京平成大学, 薬学部, 教授 (90344069)
町田 昌明 星薬科大学, 薬学部, 准教授 (80421212)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | Annexin A8 / 膵癌 / アネキシン |
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| Outline of Final Research Achievements |
Pancreatic cancers demonstrate the worst prognosis of all the major cancers. Therefore, we must find effective markers for early diagnosis and/or identify novel molecular therapeutic targets. We clarified that changes in expression levels of ANXA8 were associated with anticancer drug sensitivity in cancer cell lines, and that ANXA8 was secreted extracellularly in pancreatic cancer cell lines.
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Report
(5 results)
Research Products
(4 results)
