Development of novel pancreatic cancer diagnostic and therapeutic method targeting Annexin A8

• Project/Area Number: 25430141
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Tumor diagnostics
• Research Institution: Nihon University (2016); Showa University (2013-2015)
• Principal Investigator: HATA Harumi 日本大学, 薬学部, 准教授 (00396441)
• Co-Investigator(Kenkyū-buntansha): 立道 昌幸 東海大学, 医学部, 教授 (00318263) ; 小林 秀昭 帝京平成大学, 薬学部, 教授 (90344069) ; 町田 昌明 星薬科大学, 薬学部, 准教授 (80421212)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: Annexin A8 / 膵癌 / アネキシン

Outline of Final Research Achievements

Pancreatic cancers demonstrate the worst prognosis of all the major cancers. Therefore, we must find effective markers for early diagnosis and/or identify novel molecular therapeutic targets. We clarified that changes in expression levels of ANXA8 were associated with anticancer drug sensitivity in cancer cell lines, and that ANXA8 was secreted extracellularly in pancreatic cancer cell lines.

Research Products

• [Journal Article] Induction of activation-induced cytidine deaminase by a not-directly mutagenic carcinogen: a novel potential molecular mechanism. (2014)
  • Author(s): Tatemichi M, Hata H, Nakadate T.
  • Journal Title: Environ Health Prev Med Volume: 19 Issue: 3 Pages: 238-44
  • DOI: 10.1007/s12199-014-0382-x
  • NAID: 50009145426
  • Peer Reviewed
• [Presentation] 大腸癌細胞株においてANXA8はイリノテカンの抗腫瘍効果を減じる？ (2015)
  • Author(s): 畑春実、町田昌明、小林秀昭、立道昌幸、中館俊夫
  • Organizer: 第38回分子生物学会年会・第88回生化学会大会合同大会
  • Place of Presentation: 兵庫県、神戸市
  • Year and Date: 2015-12-01
• [Presentation] CYP1A1遺伝子は内臓肥満に関与する？ヒト化マウスによる解析 (2015)
  • Author(s): 畑春実、立道昌幸、町田昌明、細野知彦、荒田悟、小林秀昭、中館俊夫
  • Organizer: 第38回分子生物学会年会・第88回生化学会大会合同大会
  • Place of Presentation: 兵庫県、神戸市
  • Year and Date: 2015-12-01
• [Presentation] 膵癌におけるアネキシンＡ８の異所性発現におけるエピジェネティクスの関与：Ectopic expression of Annexin A8 in pancreatic cancer cells by epigenetic regulation. (2013)
  • Author(s): 畑春実、立道昌幸、町田昌明、中館俊夫
  • Organizer: 第7回日本エピジェネティクス研究会
  • Place of Presentation: 奈良