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Pharmacological potential of curcumin analog targeting KSRP, a regulator of miRNA

Research Project

Project/Area Number 25430147
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Tumor therapeutics
Research InstitutionAkita University

Principal Investigator

Shibata Hiroyuki  秋田大学, 医学(系)研究科(研究院), 教授 (50260071)

Co-Investigator(Kenkyū-buntansha) IWABUCHI Yoshiharu  東北大学, 大学院薬学研究科, 教授 (20211766)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsクルクミン / mRNA / miRNA / KSRP / microRNA / メッセンジャーRNA(mRNA) / マイクロRNA(miRNA) / 大腸がん / 悪性リンパ腫 / 血管内皮細胞 / 腫瘍血管新生
Outline of Final Research Achievements

Effects on mRNA and miRNA by curcumin analogs, GO-Y030 and GO-Y078, were examined. BCL-2, c-Myc and p53 were included in the affected transcripts by GO-Y030 among 41,058 transcripts in colorectal cancer cell line. Among 2,669 species of miRNAs in colorectal cancer cell line, 28 species and 11 species of miRNAs were up-regulated by GO-Y030 and GO-Y078, respectively. In endothelial cells, 470 species of mRNAs were up-regulated and 243 species were down-regulated. As for miRNA, has-miR-19b-3p was up-regulated in endothelial cells by GO-Y030, and 5 species of miRNAs were down-regulated by GO-Y078. KSRP contribution to the regulation of mRNA or miRNA expression was not elucidated at this present.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (8 results)

All 2016 2015 2014 2013 Other

All Journal Article (1 results) Presentation (4 results) Remarks (3 results)

  • [Journal Article] クルクミン誘導体による胃がん予防研究2015

    • Author(s)
      柴田浩行
    • Journal Title

      Functional food: 機能性食品の基礎から臨床へ

      Volume: 9 Pages: 18-22

    • Related Report
      2015 Annual Research Report
  • [Presentation] 血管新生阻害剤スニチニブやソラフェニブ耐性の打破を目指した新規化合物の開発2016

    • Author(s)
      島津 和弘、福田 耕二、吉田 泰一、井上 正広、柴田 浩行
    • Organizer
      第20回日本がん分子標的治療学会
    • Place of Presentation
      別府国際コンベンションセンター
    • Year and Date
      2016-05-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] 新たな血管新生阻害薬としてのクルクミンアナログの開発2014

    • Author(s)
      柴田浩行
    • Organizer
      BIO TECH2014 アカデミックフォーラム
    • Place of Presentation
      東京ビックサイト
    • Year and Date
      2014-05-14
    • Related Report
      2014 Research-status Report
  • [Presentation] Development of a treatment for cutaneous T cell lymphoma by newly synthesized curcumin analog.2013

    • Author(s)
      小峰啓吾, 大塚和令, 柴田浩行
    • Organizer
      日本臨床腫瘍学会
    • Place of Presentation
      仙台国際センター, 宮城県仙台市
    • Related Report
      2013 Research-status Report
  • [Presentation] 新規クルクミンアナログによる皮膚T細胞性リンパ腫の薬物療法の開発

    • Author(s)
      小峰啓吾, 岩渕好治, 大塚和令, 柴田浩行
    • Organizer
      日本がん分子標的治療学会
    • Place of Presentation
      国立京都国際会館, 京都府京都市
    • Related Report
      2013 Research-status Report
  • [Remarks] 秋田大学大学院医学系研究科医学専攻腫瘍制御医学系臨床腫瘍学講座

    • URL

      http://www.med.akita-u.ac.jp/~medonco/

    • Related Report
      2015 Annual Research Report
  • [Remarks] 秋田大学大学院医学系研究科腫瘍制御医学系臨床腫瘍学講座 クルクミン物語

    • URL

      http://www.med.akita-u.ac.jp/~medonco/

    • Related Report
      2014 Research-status Report
  • [Remarks] クルクミンアナログ物語

    • URL

      http://www.med.akita-u.ac.jp/~medonco/forgeneral.html

    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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