Development of novel therapeutic strategy targeting CML stem cells through STAT-C/EBPbeta pathway

• Project/Area Number: 25430149
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Tumor therapeutics
• Research Institution: Kyoto University
• Principal Investigator: Yokota Asumi 京都大学, 医学(系)研究科(研究院), 研究員 (00571556)
• Co-Investigator(Kenkyū-buntansha): HIRAI Hideyo 京都大学, 医学研究科, 助教 (50315933)
• Co-Investigator(Renkei-kenkyūsha): MAEKAWA Taira 京都大学, 医学研究科, 教授 (80229286)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 転写因子 / 慢性骨髄性白血病 / 白血病幹細胞 / サイトカイン

Outline of Final Research Achievements

By analysis using a next-generation sequencer, we identified a novel 3’ distal enhancer region of Cebpb, where STAT5 are recruited in a BCR-ABL signaling-dependent manner.
We also found that IFNα, which has been used for the treatment of CML, can efficiently upregulate C/EBPβ expression, and promote exhaustion and differentiation of CML stem cells through C/EBPβ. Interestingly, IFNα phosphorylate STAT5 including STAT1 and STAT3, and recruited STAT5 to a Cebpb enhancer region, which we identified in this study. IFNα also decreased CML stem cells in a mouse model, and this effect is abolished in C/EBPβ-deficient CML stem cells, indicating that the in vivo effect of IFNα is mediated by C/EBPβ.

Research Products

• [Journal Article] Accelerated apoptosis of peripheral blood monocytes in Cebpb-deficient mice. (2015)
  • Author(s): Tamura A, Hirai H, Yokota A, Sato A, Shoji T, Kashiwagi T, Iwasa M, Fujishiro A, Miura Y, Maekawa T.
  • Journal Title: Biochem Biophys Res Commun Volume: 464 Issue: 2 Pages: 654-658
  • DOI: 10.1016/j.bbrc.2015.07.045
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Non-Steady-State Hematopoiesis Regulated by the C/EBPβ Transcription Factor. (2015)
  • Author(s): Hirai H, Yokota A, Tamura A, Sato A, Maekawa T.
  • Journal Title: Cancer Sci Volume: 106 Issue: 7 Pages: 797-802
  • DOI: 10.1111/cas.12690
  • NAID: 120005767014
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Isolation of mesenchymal stromal/stem cells from small-volume umbilical cord blood units that do not qualify for the banking system. (2015)
  • Author(s): Yoshioka S, #Miura Y, Iwasa M, Fujishiro A, Yao H, Miura M, Fukuoka M, Nakagawa Y, Yokota A, Hirai H, Ichinohe T, Takaori-Kondo A, Maekawa T (#Corresponding author).
  • Journal Title: International Journal of Hematology Volume: 102 Issue: 2 Pages: 218-229
  • DOI: 10.1007/s12185-015-1828-7
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] HAX1 in induced pluripotent stem cells from a patient with severe congenital neutropenia improves defective granulopoiesis. (2014)
  • Author(s): Morishima T, Watanabe K, Niwa A, Hirai H, Saida S, Tanaka T, Kato I, Umeda K, Hiramatsu H, Saito MK, Matsubara K, Adachi S, Kobayashi M, Nakahata T, Heike T
  • Journal Title: Haematologica Volume: 99(1) Issue: 1 Pages: 19-27
  • DOI: 10.3324/haematol.2013.083873
  • Peer Reviewed / Open Access
• [Journal Article] CCAAT/Enhancer-Binding Protein β Expressed by Bone Marrow Mesenchymal Stromal Cells Regulates Early B-Cell Lymphopoiesis (2014)
  • Author(s): Yoshioka S, Miura Y, Yao H, Satake S, Hayashi Y, Tamura A, Hishita T, Ichinohe T, Hirai H, Takaori-Kondo A, Maekawa T
  • Journal Title: Stem Cells Volume: 32 Issue: 3 Pages: 730-740
  • DOI: 10.1002/stem.1555
  • Peer Reviewed
• [Journal Article] CCR1-mediated Accumulation of Myeloid Cells in the Liver Microenvironment Promoting Mouse Colon Cancer Metastasis (2014)
  • Author(s): Hirai H, et al
  • Journal Title: Clinical and Experimental Metastasis Volume: 32 Issue: 8 Pages: 2245-55
  • DOI: 10.1002/stem.1701
  • Peer Reviewed / Open Access
• [Journal Article] Loss of SMAD4 from colorectal cancer cells promotes CCL15 expression to recruit CCR1+ myeloid cells and facilitate liver metastasis. (2013)
  • Author(s): Itatani Y, Kawada K, Fujishita T, Kakizaki F, Hirai H, Matsumoto T, Iwamoto M, Inamoto S, Hatano E, Hasegawa S, Maekawa T, Uemoto S, Sakai Y, Taketo MM
  • Journal Title: Gastroenterol Volume: 145(5) Issue: 5 Pages: 1064-1075
  • DOI: 10.1053/j.gastro.2013.07.033
  • NAID: 120005348333
  • Peer Reviewed
• [Journal Article] Myeloid-Derived Suppressor Cells Play Crucial Roles in the Regulation of Mouse Collagen-Induced Arthritis. (2013)
  • Author(s): 1. Fujii W, Ashihara E, Hirai H, Nagahara H, Kajitani N, Fujioka K, Murakami K, Seno T, Yamamoto A, Ishino H, Kohno M, Maekawa T, Kawahito Y.
  • Journal Title: J Immunol Volume: 191 Issue: 3 Pages: 1073-1081
  • DOI: 10.4049/jimmunol.1203535
  • Peer Reviewed
• [Journal Article] C/EBPβ promotes BCR-ABL-mediated myeloid expansion and leukemic stem cell exhaustion. (2013)
  • Author(s): 5. Hayashi Y, Hirai H, Kamio N, Yao H, Yoshioka S, Miura Y, Ashihara E, Fujiyama Y, Tenen DG, Maekawa T.
  • Journal Title: Leukemia Volume: 27 Issue: 3 Pages: 619-628
  • DOI: 10.1038/leu.2012.258
  • NAID: 120005466670
  • Peer Reviewed
• [Journal Article] Distinct transforming activity of ABL family tyrosine kinase oncogenes is induced by their C-terminal domain. (2013)
  • Author(s): Okuda K, Hirai H
  • Journal Title: Open Journal of Blood Diseases Volume: 3 Pages: 23-33
  • Peer Reviewed
• [Journal Article] 慢性期CMLと類白血病反応に共通する分子機構. (2013)
  • Author(s): 林 嘉宏、平位秀世、前川 平
  • Journal Title: 血液内科 Volume: 67(5) Pages: 638-645
  • NAID: 40019901724
• [Journal Article] 好中球分化異常と疾患 (2013)
  • Author(s): 平位秀世
  • Journal Title: 臨床血液 Volume: 54(10) Pages: 27-38
  • NAID: 10031196300
• [Presentation] 慢性骨髄性白血病の病態形成における転写因子C/EBPβの機能 (2016)
  • Author(s): 横田明日美、平位秀世、林 慶紘、前川 平
  • Organizer: 第20回造血器腫瘍研究会
  • Place of Presentation: 千葉
  • Year and Date: 2016-02-12
• [Presentation] C/EBPβ Isoforms Distinctively and Collaboratively Regulate the Behavior of Hematopoietic Stem and Progenitor Cells in Regenerative Conditions. (2015)
  • Author(s): Sato A, Hirai H, Yokota A, Tamura A, Shoji T, Kashiwagi T, Iwasa M, Fujishiro A, Miura Y, Maekawa T
  • Organizer: American Society of Hematology, 57th Annual Meeting
  • Place of Presentation: Orland, FL, USA
  • Year and Date: 2015-12-07
  • Int'l Joint Research
• [Presentation] Bortezomib Attenuates Adhesion of B Cell Precursor Acute Lymphoblastic Lleukemia Cells to Bone Marrow Mesenchymal Stromal/Stem Cells Via Regulating SPARC Expression. (2015)
  • Author(s): Iwasa M, Miura Y, Fujishiro A, Fujii S, Sugino N, Tamura A, Sato A, Yokota A, Yoshioka S, Kito K, Ando A, Hirai H, Takaori-Kondo A, Ichinohe T, Maekawa T
  • Organizer: American Society of Hematology, 57th Annual Meeting
  • Place of Presentation: Orland, FL, USA
  • Year and Date: 2015-12-07
  • Int'l Joint Research
• [Presentation] A Constitutively-Active ABL Family Kinase, TEL-ARG, Induces Lethal Mastocytosis through Sensitizing Hematopoietic Stem/Progenitor Cells to IL-3. (2015)
  • Author(s): Yokota A, Hirai H, Shoji T, Maekawa T, Okuda K
  • Organizer: American Society of Hematology, 57th Annual Meeting
  • Place of Presentation: Orland, FL, USA
  • Year and Date: 2015-12-06
  • Int'l Joint Research
• [Presentation] Csf1r Is a Downstream Target of C/EBPβ in Ly6C- Monocytes. (2015)
  • Author(s): Tamura A, Hirai H, Yokota A, Sato A, Shoji T, Kashiwagi T, Iwasa M, Fujishiro A, Miura Y, Maekawa T
  • Organizer: American Society of Hematology, 57th Annual Meeting
  • Place of Presentation: Orland, FL, USA
  • Year and Date: 2015-12-05
  • Int'l Joint Research
• [Presentation] Vitamin K2 Supports Hematopoiesis through Acting on Bone Marrow Mesenchymal Stromal/Stem Cells. (2015)
  • Author(s): Fujishiro A, Miura Y, Iwasa M, Fujii S, Tamura A, Sato A, Yokota A, Sugino N, Hirai H, Ando A, Takaori-Kondo A, Ichinohe T, Maekawa T
  • Organizer: American Society of Hematology, 57th Annual Meeting
  • Place of Presentation: Orland, FL, USA
  • Year and Date: 2015-12-05
  • Int'l Joint Research
• [Presentation] M-CSF receptor is a downstream target of C/EBPβ in Ly6C monocytes development. (2015)
  • Author(s): Tamura A, Hirai H, Yokota A, Sato A, Shoji T, Iwasa M, Fujishiro A, Miura Y, Maekawa T
  • Organizer: 第77回日本血液学会学術総会
  • Place of Presentation: 金沢
  • Year and Date: 2015-10-18
• [Presentation] Effects of low-dose irradiation on human bone marrow mesenchymal stromal/stem cells. (2015)
  • Author(s): Fujishiro A, Miura Y, Iwasa M, Tamura A, Sato A, Yokota A, Hirai H, Ando A, Maekawa T, Ichinohe T
  • Organizer: 第77回日本血液学会学術総会
  • Place of Presentation: 金沢
  • Year and Date: 2015-10-17
• [Presentation] C/EBPβ facilitates cell cycle entry of HSPCs in response to hematological stresses. (2015)
  • Author(s): Sato A, Hirai H, Tamura A, Yokota A, Shoji T,Iwasa M, Fujishiro A, Miura Y, Maekawa T
  • Organizer: 第77回日本血液学会学術総会
  • Place of Presentation: 金沢
  • Year and Date: 2015-10-16
• [Presentation] TEL-ARG and TEL-ABL activate distinct differentiation pathways in response to IL-3. (2015)
  • Author(s): Yokota A, Hirai H, Shoji T, Maekawa T, Okuda K
  • Organizer: 第77回日本血液学会学術総会
  • Place of Presentation: 金沢
  • Year and Date: 2015-10-16
• [Presentation] ボルテゾミブは前駆B細胞性白血病細胞の骨髄間葉系幹細胞への接着を減弱させる。 (2015)
  • Author(s): 岩佐磨佐紀、三浦康生、藤城綾、杉野典子、佐藤淳至、田村彰広、横田明日美、木藤克之、平位秀世、安藤朗、高折晃史、一戸辰夫、前川平
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-10-10
• [Presentation] TEL-ABLとTEL-ARGは異なる細胞分化経路を活性化して白血病発症を誘導する. (2015)
  • Author(s): 横田明日美、平位秀世、庄司月美、前川 平、奥田恵子
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-10-10
• [Presentation] IFNα promotes differentiation of BCR-ABL+ leukemic cells through upregulating C/EBPβ. (2015)
  • Author(s): Yokota A, Hirai H, Hayashi Y, Tamura A, Sato A, Iwasa M, Fujishiro A, Shoji T, Miura Y, Maekawa T
  • Organizer: International Society for Experimental Hematology, 44th Annual Scientific Meeting
  • Place of Presentation: 京都
  • Year and Date: 2015-09-17
  • Int'l Joint Research
• [Presentation] CMLに対するIFNαの作用における転写因子C/EBPβの関与 (2015)
  • Author(s): 横田明日美、平位秀世、林嘉宏、田村彰広、佐藤淳至、岩佐麿佐紀、藤城綾、庄司月美、三浦康生、前川 平
  • Organizer: 平成26年度文部科学省新学術領域研究 がん研究分野の特性等を踏まえた支援活動 公開シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2015-01-28
• [Presentation] Essential Roles of C/EBPβ in Survival of Ly6C– monocytes (2014)
  • Author(s): Tamura A, Hirai H, Yokota A, Sato A, Yao H, Iwasa M, Fujishiro A, Miura Y, Maekawa T
  • Organizer: American Society of Hematology, 56th Annual Meeting
  • Place of Presentation: San Francisco, USA
  • Year and Date: 2014-12-08
• [Presentation] C-Terminal Domain of ABL Family Kinases, ABL and ARG, Defines Their Distinct Leukemogenic Activities in Vivo (2014)
  • Author(s): Yokota A, Hirai H, Shoji T, Maekawa T, Okuda K
  • Organizer: American Society of Hematology, 56th Annual Meeting
  • Place of Presentation: San Francisco, USA
  • Year and Date: 2014-12-07
• [Presentation] Effects of Irradiation on the Functional Characteristics of Human Bone Marrow Mesenchymal Stromal/Stem Cells (2014)
  • Author(s): Iwasa M, Miura Y, Fujishiro A, Tamura A, Sato A, Yokota A, Nakagawa Y, Yoshioka S, Hirai H, Andoh A, Ichinohe T Maekawa T
  • Organizer: American Society of Hematology, 56th Annual Meeting
  • Place of Presentation: San Francisco, USA
  • Year and Date: 2014-12-06
• [Presentation] C-terminal domain of ABL and ARG kinases defines their distinct leukemogenic activities in mice (2014)
  • Author(s): Yokota A, Hirai H, Maekawa M, Okuda K
  • Organizer: 第76回日本血液学会学術総会
  • Place of Presentation: 大阪
  • Year and Date: 2014-11-02
• [Presentation] Effect of irradiation on the characteristics of human bone marrow mesenchymal stromal/stem cells (2014)
  • Author(s): Iwasa M, Miura Y, Yao H, Yoshioka S, Fujishiro A, Tamura A, Sato A, Yokota A, Hirai H, Ando A, Ichinohe T, Maekawa T
  • Organizer: 第76回日本血液学会学術総会
  • Place of Presentation: 大阪
  • Year and Date: 2014-11-01
• [Presentation] Isolation of mesenchymal stromal/stem cells from UCB ineligible for public UCB donation (2014)
  • Author(s): Yoshioka S, Miura Y, Yao H, Iwasa M, Fujishiro A, Higashi Y, Yokota A, Tamura A, Sato A, Hirai H, Ichinohe T, Takaori-Kondo A, Maekawa T
  • Organizer: 第76回日本血液学会学術総会
  • Place of Presentation: 大阪
  • Year and Date: 2014-11-01
• [Presentation] Involvement of C/EBPβ in IFNα-induced differentiation of BCR-ABL-expressing leukemic cells (2014)
  • Author(s): Yokota A, Hirai H, Hayashi Y, Tamura A, Sato A, Yao H,Yoshioka S, Iwasa M, Miura Y, Maekawa T
  • Organizer: 第76回日本血液学会学術総会
  • Place of Presentation: 大阪
  • Year and Date: 2014-10-31
• [Presentation] C/EBPβ promotes initial expansion and exhaustion of hematopoietic stem cells in response to stresses (2014)
  • Author(s): Sato A, Hirai H, Tamura A, Yokota A, Hayashi Y, Yao H, Yoshiioka S, Iwasa M, Miura Y, Maekawa T
  • Organizer: 第76回日本血液学会学術総会
  • Place of Presentation: 大阪
  • Year and Date: 2014-10-31
• [Presentation] Critical roles of C/EBPβ for survival of Ly6C-Monocytes (2014)
  • Author(s): Tamura A, Hirai H, Yokota A, Sato A, Yao H, Yoshioka S, Iwasa M, Miura Y, Ashihara E, Maekawa T
  • Organizer: 第76回日本血液学会学術総会
  • Place of Presentation: 大阪
  • Year and Date: 2014-10-31
• [Presentation] BCR-ABL発現白血病細胞に対するC/EBPβを介したIFNαの作用 (2014)
  • Author(s): 横田明日美、平位秀世、林 嘉宏、田村彰広、佐藤淳至、八尾尚幸、岩佐麿佐紀、藤城 綾、三浦康生、前川 平
  • Organizer: 第73回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2014-09-26
• [Presentation] 間葉系幹細胞と副甲状腺ホルモンを応用した造血細胞の増幅. (2014)
  • Author(s): 三浦康生、八尾尚幸、吉岡 聡、岩佐磨佐紀、田村彰広、佐藤 淳、横田明日美、平位秀世、一戸辰夫、前川 平
  • Organizer: 第36回日本造血細胞移植学会総会
  • Place of Presentation: 沖縄
• [Presentation] Myeloid-derived suppressor cells play crucial roles in the regulation of mouse collagen-induced arthritis. (2013)
  • Author(s): Fujii W, Ashihara E, Hirai H, Fujioka K, Seno T, Ishino H, Kawahito Y
  • Organizer: Annual Meeting of the Japanese Society for Immunology
  • Place of Presentation: 千葉
• [Presentation] Direct Interaction with Bone Marrow Mesenchymal Stromal/Stem Cells Is Required for Hematopoietic Expansion by Parathyroid Hormone. (2013)
  • Author(s): Yao H, Miura Y, Yoshioka S, Iwasa M, Sato A, Tamura A, Yokota A, Ashihara E, Ichinohe T, Hirai H, Maekawa T
  • Organizer: American Society of Hematology, 55th Annual Meeting
  • Place of Presentation: New Orleans, LA, USA
• [Presentation] Hypoxia-Adapted Myeloma Cells Possess Stem Cell Character. (2013)
  • Author(s): Ashihara E, Nakagawa Y, Yao H, Yokota A, Miura Y, Takata K, Kitamura Y, Hirai H, Maekawa T
  • Organizer: American Society of Hematology, 55th Annual Meeting
  • Place of Presentation: New Orleans, LA, USA
• [Presentation] Cytokine-STATs signalings upregulate endogenous C/EBPβ in BCR-ABL+ leukemic cells independently from BCR-ABL signaling. (2013)
  • Author(s): Yokota A, Hirai H, Hayashi Y, Tamura A, Sato A, Yao H, Yoshioka S, Iwasa M, Ashihara E, Miura Y, Maekawa T
  • Organizer: American Society of Hematology, 55th Annual Meeting
  • Place of Presentation: New Orleans, LA, USA
• [Presentation] Cell-intrinsic and -extrinsic involvement of C/EBPβ in the regulation of hematopoietic stem cells. (2013)
  • Author(s): Tamura A, Hirai H, Hayashi Y, Yokota A, Sato A, Yao H, Yoshioka S, Iwasa M, Ashihara E, Miura Y, Maekawa T
  • Organizer: American Society of Hematology, 55th Annual Meeting
  • Place of Presentation: New Orleans, LA, USA
• [Presentation] C/EBPβ expressed by bone marrow mesenchymal stromal cells is indispensable for precursor B-cell lymphopoiesis. (2013)
  • Author(s): Yoshioka S, Miura Y, Yao H, Iwasa M, Sato A, Tamura A, Yokota A, Hishita T, Ichinohe T, Hirai H, Maekawa T
  • Organizer: American Society of Hematology, 55th Annual Meeting
  • Place of Presentation: New Orleans, LA, USA
• [Presentation] 骨髄移植症例におけるドナー由来HLA抗体への対応. (2013)
  • Author(s): 万木紀美子、三浦康生、菱田理恵、北脇年雄、錦織桃子、菱澤方勝、近藤忠一、北野俊行、芦原英司、高折晃史、平位秀世、前川 平
  • Organizer: 第100回近畿血液学地方会
  • Place of Presentation: 大阪
• [Presentation] 高頻度抗原に対する不規則抗体（抗Jra抗体）の抗体価推移の検討． (2013)
  • Author(s): 万木紀美子、平位秀世、藤本康弘、丹羽紀実、竹川良子、菱田理恵、三浦康生、上本伸二
  • Organizer: 第75回日本血液学会総会
  • Place of Presentation: 札幌
• [Presentation] Proliferation and differentiation of hematopoietic cells by osteogenic-induced bone marrow MSCs. (2013)
  • Author(s): Yao H, Miura Y, Yoshioka S, Iwasa M, Sato A, Hayashi Y, Tamura A, Yokota A, Ichinohe T, Tohyama K, Hirai H, Maekawa T
  • Organizer: The 75th Annual Meeting of the Japanese Society of Hematology
  • Place of Presentation: 札幌
• [Presentation] 好中球分化異常と疾患. (2013)
  • Author(s): 平位秀世
  • Organizer: 第75回日本血液学会総会
  • Place of Presentation: 札幌
• [Presentation] Involvement of C/EBPβ in the regulation of hematopoietic stem cells. (2013)
  • Author(s): Tamura A, Hirai H, Hayashi Y, Yokota A, Yao H, Yoshioka S, Sato A, Iwasa M, Ashihara E, Miura Y, and Maekawa T
  • Organizer: The 75th Annual Meeting of the Japanese Society of Hematology
  • Place of Presentation: 札幌
• [Presentation] コラーゲン誘導関節炎におけるMyeloid-derived suppressor cellsは関節炎の制御に重要な役割を果たす. (2013)
  • Author(s): 藤井渉、芦原英司、平位秀世、村上憲、妹尾高宏、山本相浩、石野秀岳、河野正孝、前川平、川人豊
  • Organizer: 第34回日本炎症・再生医学会
  • Place of Presentation: 京都
• [Presentation] 転写因子C/EBPβは骨髄系分化・増殖の誘導によりCML幹細胞を減少させる. (2013)
  • Author(s): 林 嘉宏、平位秀世、横田明日美、八尾尚幸、三浦康生、芦原英司、前川 平
  • Organizer: 第17回日本がん分子標的治療学会学術総会
  • Place of Presentation: 京都
• [Presentation] Myeloid-derived suppressor cells have regulatory roles in mouse collagen-induced arthritis. (2013)
  • Author(s): Fujii W, Ashihara E, Hirai H, Nagahara H, Fujioka K, Murakami K, Seno T, Yamamoto A, Ishino H, Kohno M, Maekawa T, Kawahito Y
  • Organizer: Annual European Congress of Rheumatology
  • Place of Presentation: Madrid, Spain
• [Presentation] 転写因子C/EBPβはカンジダ感染後の造血幹細胞・骨髄系前駆細胞の増殖を制御する. (2013)
  • Author(s): 田村彰広、平位秀世、佐竹早紀子、志馬伸朗、佐和貞治
  • Organizer: 第87回日本感染症学会
  • Place of Presentation: 横浜
• [Presentation] 接着法による効率的なさい帯血からの間葉系幹細胞分離に関する検討. (2013)
  • Author(s): 吉岡聡、三浦康生、万木紀美子、平位秀世、東 弥生、高折晃史、前川 平
  • Organizer: 第61回日本輸血・細胞治療学会総会
  • Place of Presentation: 横浜
• [Presentation] 高頻度抗原に対する不規則抗体および複合抗体陽性の肝臓移植症例への対応 ― 院内および血液センターとの連携の重要性 ―． (2013)
  • Author(s): 万木紀美子、平位秀世、藤本康弘、河村朋子、樋口征昭、丹羽紀美、竹川良子、菱田理恵、三浦康生、辻 肇、上本伸二、前川 平
  • Organizer: 第61回日本輸血・細胞治療学会総会
  • Place of Presentation: 横浜
• [Presentation] Parathyroid hormone enhances expansion through CDH11 in human bone marrow mesenchymal stromal/stem cells. (2013)
  • Author(s): Yao H, Miura Y, Yoshioka S, Hayashi Y, Yokota A, Tamura A, Ichinohe T, Hirai H and Maekawa T
  • Organizer: AsiaCORD 2013, Scientific Symposium I-1 “New Insights into Stem Cell Biology- Stem Cell Development & Differentiation”
  • Place of Presentation: 神戸
• [Presentation] C/EBPβ in mesenchymal stromal/stem cells regulates early B cell lymphopoiesis. (2013)
  • Author(s): Yoshioka S, Miura Y, Yao H, Hayashi Y, Tamura A, Hishita T, Ichinohe T, Hirai H, Takaori-Kondo A and Maekawa T
  • Organizer: AsiaCORD 2013, Scientific Symposium I-1 “New Insights into Stem Cell Biology- Stem Cell Development & Differentiation”
  • Place of Presentation: 神戸
• [Remarks] 京都大学医学部附属病院輸血細胞治療部
  • URL: http://dtm.kuhp.kyoto-u.ac.jp
• [Remarks] 京都大学医学部附属病院輸血細胞治療部ホームページ
  • URL: http://dtm.kuhp.kyoto-u.ac.jp/