Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Outline of Final Research Achievements |
Recently, we have developed a hybrid small molecule named SNIPER(ER) (Specific and Non-genetic IAP-dependent Protein Eraser for Estrogen Receptor) that induces degradation of estrogen receptor alpha (ERa) proteins via ubiquitin-proteasome system. In this study, we revealed that SNIPER(ER) induces ROS production after the ERa degradation and caused necrotic cell death of MCF-7 cells, implying a therapeutic potential of SNIPER(ER) as a lead for the treatment of ERa-positive breast cancers.
|