| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Outline of Final Research Achievements |
Exposure to tobacco and silica leads to Chronic Obstructive Pulmonary Disease and silicosis respectively, diseases marked by chronic inflammation and progression. This project aims to understand the mechanisms leading to chronic inflammation in a silicosis model. We expose mice to different silica doses for one month, then monitor disease progression in the lungs over one year. We measure immune cells number and gene expression 1, 3 and 12 months after exposure. Mice exposed to high silica doses during the first month show higher levels of inflammatory chemokines and recruitment of T cells after one year. Transcriptomic analysis identified 82 genes differentially expressed, with a prominent role of the antigen processing and presentation pathway.
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