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Development of a target discovery platform by integrating data warehousing and protein function prediction

Research Project

Project/Area Number 25430186
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field System genome science
Research InstitutionNational Institutes of Biomedical Innovation, Health and Nutrition

Principal Investigator

Mizuguchi Kenji  国立研究開発法人医薬基盤・健康・栄養研究所, 医薬基盤研究所 バイオインフォマティクスプロジェクト, プロジェクトリーダー (50450896)

Co-Investigator(Renkei-kenkyūsha) MURAKAMI Yoichi  国立研究開発法人 医薬基盤・健康・栄養研究所, 医薬基盤研究所, プロジェクト研究員 (20548424)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsデータベース / 創薬ターゲット / タンパク質相互作用
Outline of Final Research Achievements

We have previously developed TargetMine, an integrated data warehouse for target prioritization. The current project aimed to integrate predicted annotations for protein functions and interactions into TargetMine and develop an in silico system for identifying drug targets and biomarkers. First, we have extended our methods for predicting DNA-binding proteins and DNA-binding residues, as well as protein interaction sites and interacting partners, applied these methods to the entire human proteome and constructed a system that can analyze both these predicted results and known annotations using TargetMine. We have then applied the integrated system to specific biological datasets, including mouse models for pulmonary diseases, and gained novel insights into the mechanisms of these diseases and novel pathways relevant for aging and inflammation.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (75 results)

All 2016 2015 2014 2013 Other

All Int'l Joint Research (2 results) Journal Article (23 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 21 results,  Acknowledgement Compliant: 6 results,  Open Access: 10 results) Presentation (43 results) (of which Int'l Joint Research: 3 results,  Invited: 11 results) Remarks (7 results)

  • [Int'l Joint Research] University College London(英国)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] Merck Research Laboratories, Merck & Co(米国)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] An integrative data analysis platform for gene set analysis and knowledge discovery in a data warehouse framework2016

    • Author(s)
      Chen Y. A., Tripathi L. P., Mizuguchi K.
    • Journal Title

      Database (Oxford)

      Volume: - Pages: baw009-baw009

    • DOI

      10.1093/database/baw009

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The diversity of H3 loops determines the antigen-binding tendencies of antibody CDR loops2016

    • Author(s)
      Tsuchiya Y., Mizuguchi K.
    • Journal Title

      Protein Sci

      Volume: 25 Issue: 4 Pages: 815-825

    • DOI

      10.1002/pro.2874

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Integration of Ligand and Structure Based Approaches for CSAR-20142015

    • Author(s)
      Prathipati P., Mizuguchi K.
    • Journal Title

      J. Chem. Inf. Model

      Volume: - Issue: 6 Pages: 974-987

    • DOI

      10.1021/acs.jcim.5b00477

    • NAID

      120007001200

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Profiles of microRNA networks in intestinal epithelial cells in a mouse model of colitis.2015

    • Author(s)
      Lee J, Park EJ, Yuki Y, Ahmad S, Mizuguchi K, Ishii KJ, Shimaoka M, Kiyono H.
    • Journal Title

      Sci Rep

      Volume: 5 Issue: 1 Pages: 18174-18174

    • DOI

      10.1038/srep18174

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Integration of Disease Entries Across OMIM, Orphanet, and a Proprietary Knowledge Base2015

    • Author(s)
      Ito M., Nakagawa S., Mizuguchi K., Okumura T.
    • Journal Title

      Current Approaches in Applied Artificial Intelligence (Lecture Note in Computer Science)

      Volume: 9101 Pages: 120-130

    • DOI

      10.1007/978-3-319-19066-2_12

    • ISBN
      9783319190655, 9783319190662
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] BIG3 inhibit the estrogen-dependent nuclear translocation of PHB2 via multiple Karyopherin-alpha proteins in breast cancer cells.2015

    • Author(s)
      Kim NH, Yoshimaru T, Chen YA, Matsuo T, Komatsu M, Miyoshi Y, Tanaka E, Sasa M, Katagiri T
    • Journal Title

      PLoS One

      Volume: 10 Issue: 6 Pages: e0127707-e0127707

    • DOI

      10.1371/journal.pone.0127707

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Retinoblastoma Binding Protein 4-Regulated Classical Nuclear Transport Is Involved in Cellular Senescence2015

    • Author(s)
      Tsujii A., Miyamoto Y., Moriyama T., Tsuchiya T., Obuse C., Mizuguchi K., Oka M., Yoneda Y.
    • Journal Title

      The Journal of Biological Chemistry

      Volume: 290 Issue: 49 Pages: 29375-29388

    • DOI

      10.1074/jbc.m115.681908

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Systems Biology Approaches to a Rational Drug Discovery Paradigm2015

    • Author(s)
      Prathipati P., Mizuguchi K.
    • Journal Title

      Current Topics in Medicinal Chemistry

      Volume: 16(9) Issue: 9 Pages: 1009-1025

    • DOI

      10.2174/1568026615666150826114524

    • NAID

      120007001199

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of potential inhibitors based on compound proposal contest: Tyrosine-protein kinase Yes as a target2015

    • Author(s)
      Chiba S, Akiyama Y, Sekijima M.
    • Journal Title

      Scientific Reports

      Volume: 5 Issue: 1 Pages: 1-13

    • DOI

      10.1038/srep17209

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Crystal structure of FtsA from Staphylococcus aureus2014

    • Author(s)
      J. Fujita, Y. Maeda, C. Nagao, Y. Tsuchiya, Y. Miyazaki, M. Hirose, E. Mizohata, Y. Matsumoto, T. Inoue, K. Mizuguchi, and H. Matsumura
    • Journal Title

      FEBS Lett.

      Volume: 588 Issue: 10 Pages: 1879-1885

    • DOI

      10.1016/j.febslet.2014.04.008

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Homology-based prodection of interactions between proteins using Averaged One-Dependence Estimators2014

    • Author(s)
      Mizuguchi K., Murakami Y.
    • Journal Title

      BMC bioinformatics

      Volume: 15 Issue: 1 Pages: 213-213

    • DOI

      10.1186/1471-2105-15-213

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Brefeldin A-inhibited guanine nucleotide-exchange protein 3 (BIG3) is predicted to interact with its partner through an ARM-type α-helical structure2014

    • Author(s)
      Mizuguchi K., Chen Y. A., Murakami Y., Ahmad S., Yoshimaru T., Katagri T.
    • Journal Title

      BMC Res Notes

      Volume: 7 Issue: 1 Pages: 435-435

    • DOI

      10.1186/1756-0500-7-435

    • NAID

      120006864075

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] High-resolution modeling of antibody structures by a combination of bioinformatics, expert knowledge, and molecular simulations.2014

    • Author(s)
      Hiroki Shirai, Kazuyoshi Ikeda, Kazuo Yamashita, Yuko Tsuchiya, Jamica Sarmiento, Shide Liang, Tatsuaki Morokata, Kenji Mizuguchi, Junichi Higo, Daron M. Standley, Haruki Nakamura
    • Journal Title

      Proteins

      Volume: 印刷中 Issue: 8 Pages: 1624-1635

    • DOI

      10.1002/prot.24591

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dextran sulfate-resistant A/Puerto Rico/8/34 influenza virus is associated with the emergence of specific mutations in the neuraminidase glycoprotein2014

    • Author(s)
      Yamada H, Nagao C, Haredy AM, Mori Y, Mizuguchi K, Yamanishi K, Okamoto S
    • Journal Title

      Antiviral Research

      Volume: 111 Pages: 69-77

    • DOI

      10.1016/j.antiviral.2014.09.002

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Altered Actions of Memantine and NMDA-Induced Currents in a New Grid2-Deleted Mouse Line.2014

    • Author(s)
      Ayako Kumagai, Akira Fujita, Tomoki Yokoyama, Yuki Nonobe, Yasuhiro Hasaba, Tsutomu Sasaki, Yumi Itoh, Minako Koura, Osamu Suzuki, Shigeki Adachi, Haruko Ryo, Arihiro Kohara, Lokesh P. Tripathi, Masato Sanosaka, Toshiki Fukushima, Taisei Nomura, Hiroshi Takemori, et al.
    • Journal Title

      Genes

      Volume: 5 Issue: 4 Pages: 1095-1114

    • DOI

      10.3390/genes5041095

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Integrated pathway clusters with coherent biological themes for target prioritisation.2014

    • Author(s)
      Chen YA.,Tripathi LP.,Dessailly BH.,Nyström-Persson J.,Ahmad S.,Mizuguchi K.,
    • Journal Title

      PLoS One

      Volume: 9 Issue: 6 Pages: e99030-e99030

    • DOI

      10.1371/journal.pone.0099030

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] 計算生物学によるシステムの理解から創薬へ、2014

    • Author(s)
      水口賢司
    • Journal Title

      生命科学から創薬へのイノベーション

      Volume: 1 Pages: 82-88

    • Related Report
      2014 Research-status Report
  • [Journal Article] Sagace 創薬・疾患研究のためのデータベース横断検索サービス2014

    • Author(s)
      水口賢司、伊藤真和吏
    • Journal Title

      今日から使える!データベース・ウェブツール達人になるための実践ガイド

      Volume: 1 Pages: 60-61

    • Related Report
      2014 Research-status Report
  • [Journal Article] Prediction of detailed enzyme functions and identification of specificity determining residues by random forests2014

    • Author(s)
      Nagao C., Nagano N., Mizuguchi K.
    • Journal Title

      PloS One

      Volume: 9 Issue: 1 Pages: e84623-e84623

    • DOI

      10.1371/journal.pone.0084623

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Functional site plasticity in domain superfamilies2013

    • Author(s)
      Dessailly B.H., Dawson N.L., Mizuguchi K., Orengo C.A.
    • Journal Title

      Biochim Biophys Acta

      Volume: 1834 Issue: 5 Pages: 874-89

    • DOI

      10.1016/j.bbapap.2013.02.042

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Understanding the biological context of NS5A-host interactions in HCV infection: a network-based approach.2013

    • Author(s)
      Tripathi LP, Kambara H, Chen YA, Nishimura Y, Moriishi K, Okamoto T, Morita E, Abe T, Mori Y, Matsuura Y, Mizuguchi K
    • Journal Title

      J Proteome Res

      Volume: 12 Issue: 6 Pages: 2537-2551

    • DOI

      10.1021/pr3011217

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Toxygates: Interactive Toxicity Analysis on a Hybrid Microarray and Linked Data Platform2013

    • Author(s)
      Johan Nyström-Persson, Yoshinobu Igarashi, Maori Ito, Mizuki Morita, Noriyuki Nakatsu, Hiroshi Yamada, Kenji Mizuguchi
    • Journal Title

      Bioinformatics

      Volume: 29 Issue: 23 Pages: 3080-3086

    • DOI

      10.1093/bioinformatics/btt531

    • NAID

      130005468755

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Targeting BIG3-PHB2 interaction to overcome tamoxifen resistance in breast cancer cells2013

    • Author(s)
      T. Yoshimaru, M. Komatsu, T. Matsuo, Y.-A. Chen, Y. Murakami, K. Mizuguchi, E. Mizohata, T. Inoue, M. Akiyama, R. Yamaguchi, S. Imoto, S. Miyano, Y. Miyoshi, M. Sasa, Y. Nakamura, and T. Katagiri
    • Journal Title

      Nature Communications

      Volume: 4 Issue: 1 Pages: 2433-2433

    • DOI

      10.1038/ncomms3443

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 構造からネットワークへ:計算生物学による創薬研究2016

    • Author(s)
      水口賢司
    • Organizer
      日本学術振興会構造生物169委員会 第49回研究会
    • Place of Presentation
      東京
    • Year and Date
      2016-03-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] アジュバント空間の解析を可能にする統合データベース2016

    • Author(s)
      水口賢司
    • Organizer
      第9回次世代アジュバント研究会
    • Place of Presentation
      大阪
    • Year and Date
      2016-01-19
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Analysis of serum microRNA expression and cytokine production profiles for understanding febrile episodes after vaccination2016

    • Author(s)
      Natsume-Kitatani Y., Ozasa K., Nakayama T., Ishii K., Mizuguchi K.
    • Organizer
      第9回次世代アジュバント研究会
    • Place of Presentation
      大阪
    • Year and Date
      2016-01-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] 健康な日本人の生活習慣と腸管免疫・腸内細菌データベースの構築:バイオインフォマティクスの視点から2016

    • Author(s)
      水口賢司
    • Organizer
      シリーズ「薬づくりの新しいR&Dモデルを探る」第11回「薬づくりと健康食品開発を結ぶ」
    • Place of Presentation
      東京
    • Year and Date
      2016-01-15
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 医薬基盤・健康・栄養研究所の創薬支援データベースとツール2015

    • Author(s)
      水口賢司, 坂手龍一, 深川明子, 五十嵐芳暢, 陳怡安, 長尾知生子
    • Organizer
      第38回日本分子生物学会年会 第88回日本分子生化学会大会 合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] データ統合と計算の融合による創薬研究2015

    • Author(s)
      水口賢司
    • Organizer
      バイオスーパーコンピューティング神戸2015
    • Place of Presentation
      神戸
    • Year and Date
      2015-11-30
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 計算システム生物学によるポリファーマコロジーへのアプローチと新たな合理的創薬パラダイム2015

    • Author(s)
      水口賢司
    • Organizer
      CBI学会2015年大会
    • Place of Presentation
      東京
    • Year and Date
      2015-10-28
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] The integration of biological data and its application to drug discovery2015

    • Author(s)
      Tsuchiya Y., Prathipati P., Mizuguchi K.
    • Organizer
      CBI学会2015年大会
    • Place of Presentation
      東京
    • Year and Date
      2015-10-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] A systems biology framework for the identification of the molecular basis of immune adjuvanticity2015

    • Author(s)
      Prathipati P., Aoshi T.,Igarashi K., Mizuguchi K.
    • Organizer
      9th Vaccine & ISV Congress
    • Place of Presentation
      ソウル(韓国)
    • Year and Date
      2015-10-18
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A systems level analysis of adjuvant transcriptomes for biomarker and target discovery2015

    • Author(s)
      Tripathi L. P., .Ito J., Aoshi T., Ishii J. K., Mizuguchi K.
    • Organizer
      9th Vaccine & ISV Congress
    • Place of Presentation
      ソウル(韓国)
    • Year and Date
      2015-10-18
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 創薬・疾患研究のためのデータベース検索システム Sagace & Toxygates2015

    • Author(s)
      長尾知生子, 五十嵐芳暢, 森田瑞樹, 陳怡安, 深川明子, 坂手龍一, 水口賢司
    • Organizer
      トーゴーの日シンポジウム2015
    • Place of Presentation
      東京
    • Year and Date
      2015-10-06
    • Related Report
      2015 Annual Research Report
  • [Presentation] トキシコゲノミクスデータの統合化を目指したOpen TG-GATEsの再RDF化について2015

    • Author(s)
      五十嵐芳暢, 伊藤真和吏, 川島秀一, 山田弘, 水口賢司
    • Organizer
      トーゴーの日シンポジウム2015
    • Place of Presentation
      東京
    • Year and Date
      2015-10-06
    • Related Report
      2015 Annual Research Report
  • [Presentation] 創薬・疾患研究への活用に向けたデータベース連携2015

    • Author(s)
      坂手龍一, 深川明子, 水口賢司, 山田弘, 塩谷恭子, 松田潤一郎, 宮本恵宏, 梅垣敬三, 小原有弘, 松山晃文
    • Organizer
      トーゴーの日シンポジウム2015
    • Place of Presentation
      東京
    • Year and Date
      2015-10-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] 創薬の初期研究における統合データウェアハウスTargetMine2015

    • Author(s)
      陳怡安,ロケシュ テリパチ,水口賢司
    • Organizer
      トーゴーの日シンポジウム2015
    • Place of Presentation
      東京
    • Year and Date
      2015-10-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] Ligand-induced conformational changes in STING are essential for its signal transduction(リガンド結合による構造変化がもたらすSTINGシグナル伝達系への影響)2015

    • Author(s)
      土屋裕子,水口賢司
    • Organizer
      第53回日本生物物理学会年会
    • Place of Presentation
      金沢
    • Year and Date
      2015-09-13
    • Related Report
      2015 Annual Research Report
  • [Presentation] 計算生物学による分子認識と生体応答の予測:がん創薬に向けて2015

    • Author(s)
      水口賢司
    • Organizer
      第2回 次世代がんインフォマティクス研究会
    • Place of Presentation
      岡山
    • Year and Date
      2015-09-11
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Effective characterisation of adjuvant transcriptomes for biomarker and target discovery2015

    • Author(s)
      Tripathi L.P., Ito J., Aoshi T., Ishii J. K., Mizuguchi K.
    • Organizer
      The 12th [BC]2 - the Basel Computational Biology Conference
    • Place of Presentation
      バーゼル(スイス)
    • Year and Date
      2015-06-07
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Pose and affinity predictions of fXa,SYK and TrmD ligands for CSAR-2014: application of an integrated ligand and protein structure based approach2015

    • Author(s)
      Prathipati P., Mizuguchi K.
    • Organizer
      JCUP VI, OpenEye Scientific Software meeting
    • Place of Presentation
      東京
    • Year and Date
      2015-06-04
    • Related Report
      2015 Annual Research Report
  • [Presentation] データウェアハウスによる創薬関連データ統合と解析の実際2015

    • Author(s)
      水口賢司
    • Organizer
      第361回 CBI学会研究講演会
    • Place of Presentation
      大阪
    • Year and Date
      2015-04-24
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 計算生物学によるシステムの理解から創薬へ2014

    • Author(s)
      水口賢司
    • Organizer
      第2回 関西ライフサイエンス・リーディングサイエンティストセミナー
    • Place of Presentation
      大阪
    • Year and Date
      2014-12-15
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 計算生物学による創薬を目指して2014

    • Author(s)
      水口賢司
    • Organizer
      IPABシンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2014-12-05
    • Related Report
      2014 Research-status Report
  • [Presentation] 創薬・疾患研究のたまのビッグデータ探索2014

    • Author(s)
      水口賢司、 坂手龍一、深川明子、五十嵐芳暢、長尾知生子、陳怡安、伊藤真和吏
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-25
    • Related Report
      2014 Research-status Report
  • [Presentation] 乳癌細胞増殖の分子機構解明から創薬へ:タンパク質構造と相互作用予測による主導2014

    • Author(s)
      水口賢司
    • Organizer
      CBI学会2014年大会
    • Place of Presentation
      東京
    • Year and Date
      2014-10-29
    • Related Report
      2014 Research-status Report
  • [Presentation] Adjuvant Database Project: comprehensive transcriptome analysis in animal models2014

    • Author(s)
      Aoshi T., Nakatsu N., Igarashi Y., Wijaya E., Ito J., Kishishita N., Standley D., Yamada H., Mizuguchi K., Ishii K.,
    • Organizer
      Keystone Symposium on The Modes of Action of Vaccine Adjuvants
    • Place of Presentation
      Seattle, Washington, USA,
    • Year and Date
      2014-10-08
    • Related Report
      2014 Research-status Report
  • [Presentation] アジュバントデータベースの開発とトキシコゲノミクスデータの統合に向けて2014

    • Author(s)
      水口賢司、五十嵐芳暢、山田弘、石井健、Nystrom J.,
    • Organizer
      トーゴ-の日シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2014-10-05
    • Related Report
      2014 Research-status Report
  • [Presentation] 創薬・疾患研究のための生物資源・疫学研究データベースの開発2014

    • Author(s)
      水口賢司、深川明子、坂手龍一、山田弘、増井徹、塩谷恭子、松田潤一郎、宮本恵宏、松山晃文
    • Organizer
      トーゴーの日シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2014-10-05
    • Related Report
      2014 Research-status Report
  • [Presentation] Integrated pathway clusters for gene set analysis and target prioritization2014

    • Author(s)
      陳怡安, Tripathi L., Dessailly B.H., Nystrom J., Ahmad S., 水口賢司,
    • Organizer
      トーゴーの日シンポジウム2014
    • Place of Presentation
      東京
    • Year and Date
      2014-10-05
    • Related Report
      2014 Research-status Report
  • [Presentation] 創薬・疾患研究のためのデータベース横断検索システム Sagace2014

    • Author(s)
      伊藤真和吏, 森田瑞樹, 五十嵐芳暢, 陳怡安, 長尾知生子, 深川明子, 坂手龍一, 水口賢司
    • Organizer
      トーゴーの日シンポジウム2014
    • Place of Presentation
      東京
    • Year and Date
      2014-10-05
    • Related Report
      2014 Research-status Report
  • [Presentation] Elucidation of antigen recognition by antibodies toward the development of a method for antibody design2014

    • Author(s)
      Mizuguchi K., Tsuchiya Y.
    • Organizer
      生命医薬情報学連合大会2014年大会
    • Place of Presentation
      仙台
    • Year and Date
      2014-10-02
    • Related Report
      2014 Research-status Report
  • [Presentation] 抗体デザイン手法の開発に向けた抗原認識機構の解明2014

    • Author(s)
      水口賢司、土屋裕子
    • Organizer
      第52回日本生物物理学会年会
    • Place of Presentation
      札幌
    • Year and Date
      2014-09-27
    • Related Report
      2014 Research-status Report
  • [Presentation] The Potential of Serum miRNA Signatures to Understand the Immune Responses to Influenza Vaccines Diseases, Systems Biology of Infectious Diseases2014

    • Author(s)
      Mizuguchi K., Ito J., Ishii J.
    • Organizer
      Systems Biology of Infectious Diseases,
    • Place of Presentation
      Seattel, WA,USA
    • Year and Date
      2014-08-18
    • Related Report
      2014 Research-status Report
  • [Presentation] Methods for the Integration of structure based and ligand based approaches to screen ‘Yes kinase inhibitors’2014

    • Author(s)
      Prathipati P., Ito J., Tsuchiya Y., Mizuguchi K.
    • Organizer
      Level-5
    • Place of Presentation
      Tokyo
    • Year and Date
      2014-07-18
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Tosygates トキシコゲノミクスデータ解析プラットフォームの実装2014

    • Author(s)
      水口賢司,五十嵐芳暢, Nystrom J., 森田瑞樹,伊藤真和吏,中津則之,山田弘
    • Organizer
      第41回日本毒性学会学術年会
    • Place of Presentation
      神戸
    • Year and Date
      2014-07-03
    • Related Report
      2014 Research-status Report
  • [Presentation] 抗体デザイン手法の開発に向けた抗原認識機構の解明2014

    • Author(s)
      水口賢司、土屋裕子
    • Organizer
      第14回日本蛋白質科学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2014-06-26
    • Related Report
      2014 Research-status Report
  • [Presentation] Kotai Antibody Builder: Automated, high-resolution structural modeling of antibodies2014

    • Author(s)
      Yamashita K., Ikeda K., Sarmiento J., Liang S., Tsuchiya Y., Mizuguchi K., Higo J., Nakamura H., Shirai H., Standley D. M.
    • Organizer
      第14回日本蛋白質科学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2014-06-26
    • Related Report
      2014 Research-status Report
  • [Presentation] Identification Of Anti-Myxovirus Resistance Protein-1 Autoantibody As A Specific Marker For Idiopathic Nonspecific Interstitial Pneumonia2014

    • Author(s)
      Mizuguchi K., Kida H., Nishikawa H., Tripathis L., Ihara S., Arai T., Hirose M., Tada Y., Suenaga T., Mori M., Yano Y., Arase H., Sakaguchi S., Inoue Y., Kumanogoh A.
    • Organizer
      EULAR 2014
    • Place of Presentation
      Paris
    • Year and Date
      2014-06-12
    • Related Report
      2014 Research-status Report
  • [Presentation] Toxygates: Applying a Toxicology Software Platform to Wheat 'omics2014

    • Author(s)
      Igarashi Y., Morita M., Ito M., Nakatsu N., Yamada H., Mizuguchi K.
    • Organizer
      Plant&Genome Asia 2014
    • Place of Presentation
      Singapore
    • Year and Date
      2014-05-19
    • Related Report
      2014 Research-status Report
  • [Presentation] バイオインフォマティクスによるシステムの理解から創薬へ2014

    • Author(s)
      水口賢司
    • Organizer
      徳島大学 疾患プロテオゲノム研究センター
    • Place of Presentation
      徳島
    • Year and Date
      2014-05-16
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Computational and systems approaches to early stage drug discovery2014

    • Author(s)
      水口賢司
    • Organizer
      中国科学院 上海生命科学研究院
    • Place of Presentation
      上海(中国)
    • Year and Date
      2014-05-06
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] TargetMine, a data warehouse system for target discovery

    • Author(s)
      陳怡安, Tripathi L., 水口賢司
    • Organizer
      トーゴーの日シンポジウム2013
    • Place of Presentation
      時事通信ホール(東京都)
    • Related Report
      2013 Research-status Report
  • [Presentation] A random-forest based method that can predict detailed enzyme functions and also identify specificity determining residues

    • Author(s)
      長尾知生子, 長野希美, 水口賢司
    • Organizer
      CBI学会2013大会
    • Place of Presentation
      タワーホール船堀(東京都)
    • Related Report
      2013 Research-status Report
  • [Presentation] Applications of an integrated data warehouse system to investigate complex biological systems

    • Author(s)
      陳怡安, Tripathi L., 水口賢司
    • Organizer
      CBI学会2013大会
    • Place of Presentation
      タワーホール船堀(東京都)
    • Related Report
      2013 Research-status Report
  • [Presentation] Data integration and protein network analysis for early stage drug discovery

    • Author(s)
      水口賢司
    • Organizer
      Structural Life Science 7th International Conference on Structural Genomics (ICSG2013-SLS)
    • Place of Presentation
      京王プラザホテル(札幌)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Remarks] TargetMineトップページ

    • URL

      http://targetmine.mizuguchilab.org

    • Related Report
      2015 Annual Research Report
  • [Remarks] TargetMine解析ワークフロー機能

    • URL

      http://targetmine.mizuguchilab.org/auxiliary-toolkit

    • Related Report
      2015 Annual Research Report
  • [Remarks] TargetMineパスウェイクラスタリング機能

    • URL

      http://targetmine.mizuguchilab.org/integrated-pathway-clusters

    • Related Report
      2015 Annual Research Report
  • [Remarks] PSOPIA - アミノ酸配列のみからの相互作用タンパク質の予測プログラム

    • URL

      http://mizuguchilab.org/PSOPIA/

    • Related Report
      2015 Annual Research Report
  • [Remarks] Research | Mizuguchi Laboratory

    • URL

      http://mizuguchilab.org/research

    • Related Report
      2015 Annual Research Report
  • [Remarks] Mizuguchi Lab Research

    • URL

      http://mizuguchilab.org/research

    • Related Report
      2014 Research-status Report
  • [Remarks] Mizuguchi Lab, Research

    • URL

      http://mizuguchilab.org/research

    • Related Report
      2013 Research-status Report

URL: 

Published: 2014-07-25   Modified: 2022-01-31  

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