Development of a target discovery platform by integrating data warehousing and protein function prediction
Project/Area Number |
25430186
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
System genome science
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Research Institution | National Institutes of Biomedical Innovation, Health and Nutrition |
Principal Investigator |
Mizuguchi Kenji 国立研究開発法人医薬基盤・健康・栄養研究所, 医薬基盤研究所 バイオインフォマティクスプロジェクト, プロジェクトリーダー (50450896)
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Co-Investigator(Renkei-kenkyūsha) |
MURAKAMI Yoichi 国立研究開発法人 医薬基盤・健康・栄養研究所, 医薬基盤研究所, プロジェクト研究員 (20548424)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | データベース / 創薬ターゲット / タンパク質相互作用 |
Outline of Final Research Achievements |
We have previously developed TargetMine, an integrated data warehouse for target prioritization. The current project aimed to integrate predicted annotations for protein functions and interactions into TargetMine and develop an in silico system for identifying drug targets and biomarkers. First, we have extended our methods for predicting DNA-binding proteins and DNA-binding residues, as well as protein interaction sites and interacting partners, applied these methods to the entire human proteome and constructed a system that can analyze both these predicted results and known annotations using TargetMine. We have then applied the integrated system to specific biological datasets, including mouse models for pulmonary diseases, and gained novel insights into the mechanisms of these diseases and novel pathways relevant for aging and inflammation.
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Report
(4 results)
Research Products
(75 results)
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[Journal Article] Crystal structure of FtsA from Staphylococcus aureus2014
Author(s)
J. Fujita, Y. Maeda, C. Nagao, Y. Tsuchiya, Y. Miyazaki, M. Hirose, E. Mizohata, Y. Matsumoto, T. Inoue, K. Mizuguchi, and H. Matsumura
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Journal Title
FEBS Lett.
Volume: 588
Issue: 10
Pages: 1879-1885
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] High-resolution modeling of antibody structures by a combination of bioinformatics, expert knowledge, and molecular simulations.2014
Author(s)
Hiroki Shirai, Kazuyoshi Ikeda, Kazuo Yamashita, Yuko Tsuchiya, Jamica Sarmiento, Shide Liang, Tatsuaki Morokata, Kenji Mizuguchi, Junichi Higo, Daron M. Standley, Haruki Nakamura
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Journal Title
Proteins
Volume: 印刷中
Issue: 8
Pages: 1624-1635
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Altered Actions of Memantine and NMDA-Induced Currents in a New Grid2-Deleted Mouse Line.2014
Author(s)
Ayako Kumagai, Akira Fujita, Tomoki Yokoyama, Yuki Nonobe, Yasuhiro Hasaba, Tsutomu Sasaki, Yumi Itoh, Minako Koura, Osamu Suzuki, Shigeki Adachi, Haruko Ryo, Arihiro Kohara, Lokesh P. Tripathi, Masato Sanosaka, Toshiki Fukushima, Taisei Nomura, Hiroshi Takemori, et al.
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Journal Title
Genes
Volume: 5
Issue: 4
Pages: 1095-1114
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Understanding the biological context of NS5A-host interactions in HCV infection: a network-based approach.2013
Author(s)
Tripathi LP, Kambara H, Chen YA, Nishimura Y, Moriishi K, Okamoto T, Morita E, Abe T, Mori Y, Matsuura Y, Mizuguchi K
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Journal Title
J Proteome Res
Volume: 12
Issue: 6
Pages: 2537-2551
DOI
Related Report
Peer Reviewed
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[Journal Article] Targeting BIG3-PHB2 interaction to overcome tamoxifen resistance in breast cancer cells2013
Author(s)
T. Yoshimaru, M. Komatsu, T. Matsuo, Y.-A. Chen, Y. Murakami, K. Mizuguchi, E. Mizohata, T. Inoue, M. Akiyama, R. Yamaguchi, S. Imoto, S. Miyano, Y. Miyoshi, M. Sasa, Y. Nakamura, and T. Katagiri
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Journal Title
Nature Communications
Volume: 4
Issue: 1
Pages: 2433-2433
DOI
Related Report
Peer Reviewed
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[Presentation] Adjuvant Database Project: comprehensive transcriptome analysis in animal models2014
Author(s)
Aoshi T., Nakatsu N., Igarashi Y., Wijaya E., Ito J., Kishishita N., Standley D., Yamada H., Mizuguchi K., Ishii K.,
Organizer
Keystone Symposium on The Modes of Action of Vaccine Adjuvants
Place of Presentation
Seattle, Washington, USA,
Year and Date
2014-10-08
Related Report
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[Presentation] Kotai Antibody Builder: Automated, high-resolution structural modeling of antibodies2014
Author(s)
Yamashita K., Ikeda K., Sarmiento J., Liang S., Tsuchiya Y., Mizuguchi K., Higo J., Nakamura H., Shirai H., Standley D. M.
Organizer
第14回日本蛋白質科学会年会
Place of Presentation
横浜
Year and Date
2014-06-26
Related Report
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[Presentation] Identification Of Anti-Myxovirus Resistance Protein-1 Autoantibody As A Specific Marker For Idiopathic Nonspecific Interstitial Pneumonia2014
Author(s)
Mizuguchi K., Kida H., Nishikawa H., Tripathis L., Ihara S., Arai T., Hirose M., Tada Y., Suenaga T., Mori M., Yano Y., Arase H., Sakaguchi S., Inoue Y., Kumanogoh A.
Organizer
EULAR 2014
Place of Presentation
Paris
Year and Date
2014-06-12
Related Report
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