Roles of ARFs in superoxide production and chemotaxis of neutrophil
| Project/Area Number |
25440051
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Functional biochemistry
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| Research Institution | Hokkaido University (2014-2015)
University of Occupational and Environmental Health, Japan (2013) |
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Principal Investigator |
MAZAKI Yuichi 北海道大学, 医学(系)研究科(研究院), 講師 (60311304)
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| Co-Investigator(Renkei-kenkyūsha) |
SABE Hisataka 北海道大学, 医学研究科, 教授 (40187282)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 好中球 / 遊走 / 活性酸素 |
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| Outline of Final Research Achievements |
Neutrophils are important in innate immunity and in the initiating an acute response to infection. During such a response, neutrophils migrate towards invaders and produce antimicrobial agents, including many reactive oxygen species. Previously, we reported that ARF regulatory factors, which are membrane trafficking protein, are involved in superoxide production and chemotaxis of neutrophils. In this study, we examined roles of ARFs in superoxide production and chemotaxis of neutrophil. Our results suggest that ARF1 is involved in subcellular localization of Rac1 during chemotaxis.
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Report
(4 results)
Research Products
(7 results)
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[Journal Article] Endothelin-1 suppresses insulin-stimulated Akt phosphorylation and glucose uptake via G protein- coupled receptor kinase 2 in skeletal muscle cells.2016
Author(s)
Horinouchi, T., Hoshi, A., Harada, T., Higa, T., Karki, S., Terada, K., Higashi, T., Mai, Y., Nepal, P., Mazaki, Y., Miwa. S.
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Journal Title
Br. J. Pharmacol
Volume: 173
Issue: 5
Pages: 1018-1032
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Overexpression of Peroxiredoxin 4 Induces Adaptive Intestinal Lipid Metabolism Associated with Suppressive Nonalcoholic Steatohepatitis in a Dietary Mouse Model.2016
Author(s)
Aya Nawata, Hirotsugu Noguchi, Yuichi Mazaki, Toshihiro Kurahashi, Atsunori Nabeshima, Ke-Yong Wang, Satoshi Kimura, Hidetaka Uramoto, Kimitoshi Kohno, Hatsumi Taniguchi, Yoshiya Tanaka, Junichi Fujii, Yasuyuki Sasaguri Toshiyuki Nakayama, and Sohsuke Yamada.
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Journal Title
PLoS One
Volume: e0152549
Issue: 4
Pages: e0152549-e0152549
DOI
Related Report
Peer Reviewed / Open Access
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