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Studies on the physiological roles and disease models of lipid droplets and lipid droplet-binding proteins

Research Project

Project/Area Number 25440053
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Functional biochemistry
Research InstitutionUniversity of Hyogo

Principal Investigator

OSUMI Takashi  兵庫県立大学, 生命理学研究科, 特任教授 (50111787)

Co-Investigator(Renkei-kenkyūsha) SAKAI Fumie  兵庫県立大学, 大学院生命理学研究科, 助教 (90623629)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords脂肪滴 / ペリリピン / リパーゼ / 心臓 / 糖尿病 / 心筋症 / 肝再生 / 精子形成 / 肝臓 / 精巣 / 国際情報交換(オーストリア) / トリグリセリド / 脂肪
Outline of Final Research Achievements

Lipid droplets (LDs) stably store lipids in living cells in the form of neutral lipids, such as triacylglycerol (TG). LDs play important roles in the regulation of energy and lipid metabolism, through permitting TG to be hydrolyzed by lipases depending on energy demand. Among LD-binding proteins, Plin family proteins (Plin1-5) play central roles in the regulation of cellular lipolysis, by limiting the actions of lipases. Hence, it is important to solve the functions of Plin proteins, for understanding the pathology of various diseases involving abnormal lipid metabolism. In this study, we investigated the mechanism by which Plin5 deteriorates diabetic cardiomyopathy and inhibitory function of Plin5 against lipases. Roles of LDs and Plin proteins in liver regeneration and spermatogenesis were also studied.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (17 results)

All 2016 2015 2014 Other

All Int'l Joint Research (1 results) Journal Article (5 results) (of which Peer Reviewed: 4 results,  Acknowledgement Compliant: 2 results,  Open Access: 1 results) Presentation (9 results) (of which Invited: 2 results) Remarks (2 results)

  • [Int'l Joint Research] グラーツ大学(オーストリア)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Heart lipid droplets and lipid droplet-binding proteins: Biochemistry, physiology, and pathology.2016

    • Author(s)
      Osumi, T., Kuramoto, K.
    • Journal Title

      Experimental Cell Research

      Volume: 340 Issue: 2 Pages: 198-204

    • DOI

      10.1016/j.yexcr.2015.10.031

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Deficiency of a lipid droplet protein, Perilipin 5, suppresses myocardial lipid accumulation, thereby preventing diabetes-induced heart malfunction2014

    • Author(s)
      Kenta Kuramoto, Fumie Sakai, Nana Yoshinori, Tomoe Y. Nakamura, Shigeo Wakabayashi, Tomoko Kojidani, Tokuko Haraguchi, Fumiko Hirose,Takashi Osumi
    • Journal Title

      Molecular and Cellular Biology

      Volume: 34(14) Issue: 14 Pages: 2721-2731

    • DOI

      10.1128/mcb.00133-14

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Long-term Expression of the Lamin A Mutant Associated with Dilated Cardiomyopathy Induces Senescence.2014

    • Author(s)
      Moriuchi T, Osumi T, Mio K, Muraoka T, Hirose F,
    • Journal Title

      Genes to Cells

      Volume: 19 Issue: 12 Pages: 901-908

    • DOI

      10.1111/gtc.12189

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Metabolic conversion of C20 polymethylene-interrupted polyunsaturated fatty acids to essential fatty acids2014

    • Author(s)
      T. Tanaka, S. Uozumi, K. Morito, T. Osumi, A. Tokumura
    • Journal Title

      Lipids

      Volume: in press Issue: 5 Pages: 423-429

    • DOI

      10.1007/s11745-014-3896-5

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 脂肪滴の機能とその調節 ― 脂肪滴結合タンパク質を中心に2014

    • Author(s)
      大隅 隆
    • Journal Title

      週刊 医学のあゆみ

      Volume: 248 Pages: 1190-1195

    • Related Report
      2013 Research-status Report
  • [Presentation] Analysis of the testicular lipid droplets (LDs) and LD-binding proteins in young mouse testis (若年マウス精巣における精巣脂肪滴と脂肪滴結合タンパク質の解析).2015

    • Author(s)
      Sakai F, Kitazawa Y, Sugimoto T, Osumi T.
    • Organizer
      第36回 日本分子生物学会年会 第88回 日本生化学会大会 合同大会
    • Place of Presentation
      神戸国際会議場(兵庫県神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] 脂肪滴結合タンパク質による脂肪滴機能の調節2015

    • Author(s)
      倉元謙太、大隅 隆
    • Organizer
      第15回 日本蛋白質科学会年会
    • Place of Presentation
      あわぎんホール(徳島県徳島市)
    • Year and Date
      2015-06-24
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] ラミンAにおけるSUMO interacting motifの同定2014

    • Author(s)
      森内昂文、黒田真希、大隅 隆、廣瀬富美子
    • Organizer
      日本分子生物学会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Research-status Report
  • [Presentation] ATGL/Plin5-ダブルノックアウトマウスを用いた心臓におけるPlin5の機能解析2014

    • Author(s)
      義則奈々、倉元謙太、Rudolf Zechner、大隅 隆
    • Organizer
      日本脂質生化学会
    • Place of Presentation
      近畿大学東大阪キャンパス(東大阪市)
    • Year and Date
      2014-06-06 – 2014-06-07
    • Related Report
      2014 Research-status Report
  • [Presentation] 非脂肪組織における脂肪滴と脂肪滴結合タンパク質の役割-Perilipin 5ノックアウトマウスの心臓の表現型解析-

    • Author(s)
      倉元謙太、酒井章衣、大隅 隆
    • Organizer
      日本生化学会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] ペルオキシソーム/ミクロソームにおける鎖長短縮/伸長反応を介した脂肪酸リモデリング

    • Author(s)
      魚住幸加、森戸克弥、大隅 隆、田中 保、徳村 彰
    • Organizer
      日本生化学会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Related Report
      2013 Research-status Report
  • [Presentation] ATGL/Plin5ダブルノックアウトマウスの心臓における表現型解析

    • Author(s)
      義則奈々、倉元謙太、酒井章衣、Zechner Rudolf、大隅 隆
    • Organizer
      日本分子生物学会
    • Place of Presentation
      神戸国際会議場(神戸市)
    • Related Report
      2013 Research-status Report
  • [Presentation] 家族性拡張型心筋症に関連するlamin A 変異体の脂肪滴への影響

    • Author(s)
      森内昂文、大隅 隆、廣瀬富美子
    • Organizer
      日本分子生物学会
    • Place of Presentation
      神戸国際会議場(神戸市)
    • Related Report
      2013 Research-status Report
  • [Presentation] Decline in SUMOylation of lamin A mutant associated with dilated cardiomyopathy is not causative ofabnormal nuclear dynamics and cellular morphology

    • Author(s)
      Takanobu Moriuchi, Takashi Osumi, Fumiko Hirose
    • Organizer
      American Society of Cell Biology Annual Meeting
    • Place of Presentation
      New Orleans(USA)
    • Related Report
      2013 Research-status Report
  • [Remarks] 細胞機能分野ホームページ

    • URL

      http://www.sci.u-hyogo.ac.jp/life/molbio/index-j.html

    • Related Report
      2014 Research-status Report
  • [Remarks] 細胞機能学分野ホームページ

    • URL

      http://www.sci.u-hyogo.ac.jp/life/molbio/index-j.html

    • Related Report
      2013 Research-status Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

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