| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Outline of Final Research Achievements |
In this study, we found 11 Rho-GEFs, which are upstream activator of Rho family small GTPases, involved in cyclic stretch-induced cell orientation in vascular endothelial cells. We focused on Solo, which is one of those Rho-GEFs, and found that Solo is required to orient the cells in response to the force derived from cadherin-based cell-cell adhesion. We also showed that Solo is required to activate RhoA and the formation of stress fibers by tensile-force application in epithelial cells.
|
