Analysis of the regulation of actin cytoskeleton remodeling through mechanotransduction in endothelial cells and epithelial cells
| Project/Area Number |
25440076
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cell biology
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | メカノシグナル / RhoGEF / アクチン骨格 / 血管内皮細胞 / 上皮細胞 / Rho / GEF / メカノセンシング / Rhoファミリー / 乳腺上皮細胞 / 細胞外基質 / Dblファミリー |
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| Outline of Final Research Achievements |
In this study, we found 11 Rho-GEFs, which are upstream activator of Rho family small GTPases, involved in cyclic stretch-induced cell orientation in vascular endothelial cells. We focused on Solo, which is one of those Rho-GEFs, and found that Solo is required to orient the cells in response to the force derived from cadherin-based cell-cell adhesion. We also showed that Solo is required to activate RhoA and the formation of stress fibers by tensile-force application in epithelial cells.
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Report
(4 results)
Research Products
(26 results)
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[Journal Article] Rho-guanine nucleotide exchange factors involved in cyclic stretch-induced reorientation of vascular endothelial cells.2015
Author(s)
Abiko, H., Fujiwara, S., Ohashi, K., Hiatari, R., Mashiko, T., Sakamoto, N., Sato, M., and Mizuno, K.
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Journal Title
J. Cell Sci.
Volume: in press
Related Report
Peer Reviewed / Acknowledgement Compliant
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