Analysis of spatiotemporal regulation of membrane traffic from the ER
| Project/Area Number |
25440079
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cell biology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
SATO Ken 東京大学, 総合文化研究科, 准教授 (00303602)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 小胞体 / COPII / 低分子量GTPase / 小胞輸送 |
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| Outline of Final Research Achievements |
Molecular mechanisms of ER exit site formation and its spatiotemporal regulation was analyzed, and a novel GTPase-activating protein (GAP) for Sar1, Nel1, was identified. Nel1 was shown to potentially regulate ER exit site formation through its GAP activity. Furthermore, domain analysis of Sec16, which has been described as the organizer of the ER exit site, identified the roles of its N-terminal, central CCD, and C-terminal domain during ER exit site formation.
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Report
(4 results)
Research Products
(14 results)
