| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Molecular mechanisms of ER exit site formation and its spatiotemporal regulation was analyzed, and a novel GTPase-activating protein (GAP) for Sar1, Nel1, was identified. Nel1 was shown to potentially regulate ER exit site formation through its GAP activity. Furthermore, domain analysis of Sec16, which has been described as the organizer of the ER exit site, identified the roles of its N-terminal, central CCD, and C-terminal domain during ER exit site formation.
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