Role of plasma membrane tension in actin polymerization
| Project/Area Number |
25440085
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cell biology
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| Research Institution | Kobe University |
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Principal Investigator |
Tsujita Kazuya 神戸大学, バイオシグナル総合研究センター, 講師 (10457054)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 細胞膜の張力 / アクチン細胞骨格 / BARタンパク質 / F-BARタンパク質 |
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| Outline of Final Research Achievements |
Tension applied to the plasma membrane (PM) is a global mechanical parameter that regulates actin polymerization. However, how membrane tension regulates actin assembly was unknown. This work showed that FBP17, a membrane-bending protein and an activator of WASP/N-WASP-dependent actin nucleation, is a PM tension-sensor involved in leading edge formation. Cell biological experiments showed that membrane tension inhibits membrane bending activity of FBP17 to negatively regulate actin polymerization.
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Report
(4 results)
Research Products
(4 results)
