| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
The TORC2 - Akt pathway is evolutionarily conserved from yeast to human. Whereas the human TORC2 pathway responds to insulin stimuli, the TORC2 pathway in a unicellular organism fission yeast directly responds to glucose in the extracellular environment. In the previous study, we utilized fission yeast as a model organism and found that Ryh1, a known activator of TORC2, is involved in glucose response of fission yeast TORC2.
In this study, we have discovered a novel mechanism that regulates TORC2 on glucose stimuli independently of Ryh1, although the precise molecular mechanism has remained to be elucidated. We have also revealed a key molecular mechanism how TORC2 activates Akt.
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