• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Reguratory mechanism of TOR Complex 2 on glucose stimuli

Research Project

Project/Area Number 25440086
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cell biology
Research InstitutionNara Institute of Science and Technology

Principal Investigator

Tatebe Hisashi  奈良先端科学技術大学院大学, バイオサイエンス研究科, 助教 (00596819)

Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
KeywordsTOR / Target Of Rapamycin / グルコース / 分裂酵母 / Rab低分子量Gタンパク質
Outline of Final Research Achievements

The TORC2 - Akt pathway is evolutionarily conserved from yeast to human. Whereas the human TORC2 pathway responds to insulin stimuli, the TORC2 pathway in a unicellular organism fission yeast directly responds to glucose in the extracellular environment. In the previous study, we utilized fission yeast as a model organism and found that Ryh1, a known activator of TORC2, is involved in glucose response of fission yeast TORC2.
In this study, we have discovered a novel mechanism that regulates TORC2 on glucose stimuli independently of Ryh1, although the precise molecular mechanism has remained to be elucidated. We have also revealed a key molecular mechanism how TORC2 activates Akt.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (7 results)

All 2017 2015 2014 2013 Other

All Journal Article (3 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (2 results) (of which Invited: 1 results) Remarks (2 results)

  • [Journal Article] Substrate specificity of TOR complex 2 is determined by a ubiquitin-fold domain of the Sin1 subunit2017

    • Author(s)
      Hisashi Tatebe, Shinichi Murayama, Toshiya Yonekura, Tomoyuki Hatano, David Richter, Tomomi Furuya, Saori Kataoka, Kyoko Furuita, Chojiro Kojima, and Kazuhiro Shiozaki
    • Journal Title

      eLife

      Volume: 6

    • DOI

      10.7554/elife.19594

    • NAID

      120005983409

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Fission yeast Ryh1 GTPase activates TOR Complex 2 in response to glucose2015

    • Author(s)
      Tomoyuki Hatano, Susumu Morigasaki, Hisashi Tatebe, Kyoko Ikeda, Kazuhiro Shiozaki
    • Journal Title

      Cell Cycle

      Volume: 14 Issue: 6 Pages: 848-856

    • DOI

      10.1080/15384101.2014.1000215

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Cyclodextrin Complexed [60]Fullerene Derivatives with High Levels of Photodynamic Activity by Long Wavelength Excitation.2013

    • Author(s)
      Ikeda A, Iizuka T, Maekubo N, Aono R, Kikuchi J, Akiyama M, Konishi T, Ogawa T, Ishida-Kitagawa N, Tatebe H, Shiozaki K
    • Journal Title

      ACS Medicinal Chemistry Letters

      Volume: 4 Issue: 8 Pages: 752-756

    • DOI

      10.1021/ml4001535

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Regulation of TOR Complex 2 (TORC2) and its physiological roles in response to the extracellular environment2014

    • Author(s)
      Hisashi Tatebe, Tomoyuki Hatano, Susumu Morigasaki, Midori Emori, Kazuhiro Shiozaki
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Research-status Report
  • [Presentation] Role of Sin1 in TORC2 signaling2013

    • Author(s)
      Hisashi Tatebe
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸国際会議場
    • Related Report
      2013 Research-status Report
    • Invited
  • [Remarks] ガン増殖を引き起こすタンパク質Sin1 の構造を明らかに|奈良先端科学技術大学院大学

    • URL

      http://www.naist.jp/news/2017/03/003680.html

    • Related Report
      2016 Annual Research Report
  • [Remarks] Yeast enzyme regulator recognized

    • URL

      http://ipw.naist.jp/iri/naura/RH_pdf/NAIST_RH-24_BS_19.pdf

    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi