| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Outline of Final Research Achievements |
The eukaryotic cell nucleus provides a three dimensional space for regulation of genomic DNA, and thus contains various nuclear architectures. The nucleolus, one of the largest nuclear domains is a site of ribosome biogenesis. It also plays roles in cellular energy homeostasis, response to cell stresses including nutritional deprivation, and cell proliferation regulation. In this study, my research group performed high content screening to identify factors involved in nucleolar formation and maintenance, and further analyzed their molecular functions to elucidate the nucleolar structure and function.
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