| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Outline of Final Research Achievements |
The aim of this research is to elucidate the molecular mechanisms that control intracellular localization of the 26S proteasome, using the fission yeast Schizosaccharomyces pombe as a model. In S. pombe, the main regulator of the localization of the proteasome is Cut8 protein and therefore we tried to find factors interacting with or regulating Cut8. Although we have not identified novel factors regulating the proteasome localization cooperating with Cut8, we could obtain several interesting results about the relationship between evolutionally conserved Greatwall-endosulfine pathway and Cut8 functions.
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