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Molecular interaction between two axes specification to built 3D body

Research Project

Project/Area Number 25440101
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Developmental biology
Research InstitutionUniversity of Tsukuba

Principal Investigator

YAGUCHI Shunsuke  筑波大学, 生命環境系, 准教授 (00505331)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords細胞分化 / 体軸形成 / 発生・分化
Outline of Final Research Achievements

The research goal is to understand the molecular mechanisms of the linkage that connects the embryonic axis specification and formation in the sea urchin. My previous work showed that the secondary axis specifier Nodal suppressed the primary axis formation. To investigate the detailed molecular mechanisms of this linkage, we blocked the function of Wnt7, as a ligand candidate for the canonical Wnt pathway. In Nodal morphants, the anterior neuroectoderm (animal plate: AP) is more restricted than that in normal embryos. However, when Wnt7 function is blocked simultaneously, the excess restriction is never happened. This result indicates that double suppression mechanism regulates the precise size control of AP region: canonical Wnt suppresses neuroectoderm and Nodal suppresses the canonical Wnt. This leads us to understand how the cell-fate is specified along with the orthogonal body axes during the early embryogenesis.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (12 results)

All 2016 2015 2014 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 2 results,  Acknowledgement Compliant: 3 results) Presentation (8 results) (of which Int'l Joint Research: 1 results,  Invited: 3 results) Remarks (1 results)

  • [Journal Article] Cooperative Wnt-Nodal signals regulate the patterning of anterior neuroectoderm.2016

    • Author(s)
      Yaguchi J, Takeda N, Inaba K, Yaguchi S
    • Journal Title

      PLoS Genetics

      Volume: 12(4) Issue: 4 Pages: 1-27

    • DOI

      10.1371/journal.pgen.1006001

    • NAID

      120007135521

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Early development and neurogenesis of Temnopleurus reevesii.2015

    • Author(s)
      Shunsuke Yaguchi, Atsuko Yamazaki, Wakana Wada, Yasutaka Tsuchiya, Toshihiko Sato, Hideo Shinagawa, Yutaro Yamada, Junko Yaguchi
    • Journal Title

      Development, Growth Differentiation

      Volume: 3 Issue: 3 Pages: 242-250

    • DOI

      10.1111/dgd.12202

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Bicaudal-C is required for the formation of anterior neurogenic ectoderm in the sea urchin embryo.2014

    • Author(s)
      Shunsuke Yaguchi, Junko Yaguchi, Kazuo Inaba
    • Journal Title

      Scientific Reports

      Volume: 4 Issue: 1 Pages: 6852-6852

    • DOI

      10.1038/srep06852

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Cooperative Wnt-Nodal signals regulate the patterning of anterior neuroectoderm.2015

    • Author(s)
      Yaguchi J, Takeda N, Inaba K, Yaguchi S.
    • Organizer
      Developmental Biology of the Sea Urchin XXIII
    • Place of Presentation
      MBL, Woods Hole, MA, USA
    • Year and Date
      2015-10-08
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Wntシグナルによるウニ胚神経外胚葉のパターニング2015

    • Author(s)
      谷口順子、谷口俊介
    • Organizer
      86th annual meeting of the Zoological Society of Japan
    • Place of Presentation
      朱鷺メッセ、新潟県新潟市
    • Year and Date
      2015-09-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] バフンウニ前端部神経外胚葉に発現する遺伝子群のパターニング解析2015

    • Author(s)
      谷口順子、谷口俊介
    • Organizer
      86th annual meeting of the Zoological Society of Japan
    • Place of Presentation
      朱鷺メッセ、新潟県新潟市
    • Year and Date
      2015-09-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] 日本産ウニ類のDNAバーコードと分類学検討2015

    • Author(s)
      廣瀬慎美子、清本正人、吉田有喜子、成瀬貢、大森紹仁、谷口俊介、中野裕昭
    • Organizer
      86th annual meeting of the Zoological Society of Japan
    • Place of Presentation
      朱鷺メッセ、新潟県新潟市
    • Year and Date
      2015-09-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] バフンウニゲノムおよびトランスクリプトームの解読と情報基盤整備2015

    • Author(s)
      金城その子、谷口俊介、山本卓、清本正人、池尾一穂
    • Organizer
      86th annual meeting of the Zoological Society of Japan
    • Place of Presentation
      朱鷺メッセ、新潟県新潟市
    • Year and Date
      2015-09-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] Bicaudal Cはウニ胚前端部神経外胚葉形成に必要である2014

    • Author(s)
      谷口 俊介、谷口 順子、稲葉 一男
    • Organizer
      日本動物学会第85回大会
    • Place of Presentation
      東北大学、仙台
    • Year and Date
      2014-09-11 – 2014-09-13
    • Related Report
      2014 Research-status Report
  • [Presentation] Maintenance of the anterior neurogenic ectoderm in the sea urchin embryo2014

    • Author(s)
      Junko Yaguchi, Atsuko Yamazaki, Akane Yamamoto, Kazuo Inaba, Shunsuke Yaguchi
    • Organizer
      Developmental Biology of the Sea Urchin XXII
    • Place of Presentation
      Woods Hole, MA, USA
    • Year and Date
      2014-04-23 – 2014-04-27
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Maintenance of the anterior neuroectoderm of the sea urchin embryo.2014

    • Author(s)
      Yaguchi S
    • Organizer
      Developmental Biology of the Sea Urchin XXII
    • Place of Presentation
      Woods Hole, MA, USA
    • Related Report
      2013 Research-status Report
    • Invited
  • [Remarks] 発生初期の胚から“脳”が形成されていく仕組みに迫る

    • URL

      http://www.tsukuba.ac.jp/attention-research/r201412021300.html

    • Related Report
      2015 Annual Research Report

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Published: 2014-07-25   Modified: 2019-07-29  

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