Specification of sensory primordia in cephalic ectoderm
| Project/Area Number |
25440106
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Developmental biology
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 転写制御因子 / 感覚器原基 / 発現制御 / 細胞分化 / エンハンサー / Sox転写因子 / Sall4 / 転写抑制因子 / 転写制御因子群 / Sox因子 / 協調的転写制御 / 内耳 / Snail/Zfh / Sox / Snail/ZFH / プラコード / 転写抑制 / 特異化 |
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| Outline of Final Research Achievements |
Sensory organ primordia are derived from the cephalic ectoderm, and specified through multiple progressive steps. The NOP1 enhancer is specifically active in nasal and otic placodes, which is regulated not only by synergistic activation of Sox2/9 and Sall4 but also by multiple repressions. Zeb1/2 and Snail1/2 zinc finger proteins could repress the NOP1 enhancer. The otic placode specific enhancer, Otic1 enhancer, is also regulated by synergistic action of Sox and Sall4. These results imply that the combination of cooperative action of Sox and Sall4 and repressions would be a key mechanism in the specification of sensory placodes.
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Report
(4 results)
Research Products
(10 results)
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[Journal Article] Regulation of trunk neural crest delamination by δEF1 and Sip1 in the chicken embryo2016
Author(s)
Yasumi, T., Inoue, M., Maruhashi, M., Kamachi, Y., Higashi, Y., Kondoh, H., Uchikawa, M.
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Journal Title
Dev. Growth. Differ.
Volume: 58
Issue: 2
Pages: 205-214
DOI
Related Report
Peer Reviewed
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