| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Sensory organ primordia are derived from the cephalic ectoderm, and specified through multiple progressive steps. The NOP1 enhancer is specifically active in nasal and otic placodes, which is regulated not only by synergistic activation of Sox2/9 and Sall4 but also by multiple repressions. Zeb1/2 and Snail1/2 zinc finger proteins could repress the NOP1 enhancer. The otic placode specific enhancer, Otic1 enhancer, is also regulated by synergistic action of Sox and Sall4. These results imply that the combination of cooperative action of Sox and Sall4 and repressions would be a key mechanism in the specification of sensory placodes.
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