| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
The midgut of Drosophila embryo consists of endodermal epithelium and visceral mesoderm, and transiently forms four chambers during development. HOX genes, Scr , Antp , Ubx , and abd-A , are expressed in the midgut visceral mesoderm. We have studied role of HOX genes in the development of midgut chambers by use of chamber-specific epithelial differentiation markers. It was found that except for differentiation of the 2nd chamber, HOX genes are not required for chamber-specific epithelial differentiation itself. Antp, which is expressed at the boundary between the 1st and 2nd chambers, regulates size of the both chambers. Antp activity was found to be mediated by EGFR signaling pathway, and all the phenotypes caused by genetic modification of Antp activity were all associated with changes in dpp expression.
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