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HOX genes regulate size balance between regions of digestive tract

Research Project

Project/Area Number 25440111
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Developmental biology
Research InstitutionYamaguchi University

Principal Investigator

MURAKAMI RYUTARO  山口大学, 医学(系)研究科(研究院), 教授 (40182109)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
KeywordsHOX genes / Drosophila / midgut / visceral mesoderm / size control / Dpp / EGFR / HOX / visceral / mesoderm / chamber / size / ショウジョウバエ / 中腸 / 内臓筋 / EGFシグナル
Outline of Final Research Achievements

The midgut of Drosophila embryo consists of endodermal epithelium and visceral mesoderm, and transiently forms four chambers during development. HOX genes, Scr , Antp , Ubx , and abd-A , are expressed in the midgut visceral mesoderm. We have studied role of HOX genes in the development of midgut chambers by use of chamber-specific epithelial differentiation markers. It was found that except for differentiation of the 2nd chamber, HOX genes are not required for chamber-specific epithelial differentiation itself. Antp, which is expressed at the boundary between the 1st and 2nd chambers, regulates size of the both chambers. Antp activity was found to be mediated by EGFR signaling pathway, and all the phenotypes caused by genetic modification of Antp activity were all associated with changes in dpp expression.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (12 results)

All 2016 2015 2014 2013

All Presentation (12 results) (of which Int'l Joint Research: 3 results)

  • [Presentation] HOX gene Antp in the visceral mesoderm regulates size of the midgut chambers in Drosophila embryo2016

    • Author(s)
      Izumi Tanoue, Keita Fujimoto, Masahiko Arishige, Yumiko Harada and Ryutaro Murakami
    • Organizer
      CDB Symposium 2016
    • Place of Presentation
      神戸ポートアイランド(兵庫,神戸)
    • Year and Date
      2016-03-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] Spatial expression pattern of digestive enzymes along the midgut of Drosophila larva2015

    • Author(s)
      Shota Hisano, Yuto Masuda, Takuya Hamano, Tatsuya Chinbe, Ryutaro Murakami
    • Organizer
      第38回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド(兵庫,神戸)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] Role of a HOX gene Antp in the midgut of Drosophila embryo2015

    • Author(s)
      Izumi Tanoue, Keita Fujimoto, Masahiko Arishige, Yumiko Harada, Ryutaro Murakami
    • Organizer
      3rd Asia-Pacific Drosophila RTesearch Conference
    • Place of Presentation
      北京(中国)
    • Year and Date
      2015-05-11
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of the visceral mesoderm of Drosophila midgut depends on the angiotensin converting enzyme (Ance) activity emanated from the endoderm2015

    • Author(s)
      Mai Hanada, Yuichi Yoshimura, Yumiko Harada, Ryutaro Murakami
    • Organizer
      3rd Asia-Pacific Drosophila RTesearch Conference
    • Place of Presentation
      北京(中国)
    • Year and Date
      2015-05-11
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Gene expression pattern of digestive enzymes in the midgut of Drosophila larvae2015

    • Author(s)
      Shota Hisano, Yuto Masuda, Takuya Hamano, Tatsuya Chinbe, Ryutaro Murakami
    • Organizer
      3rd Asia-Pacific Drosophila RTesearch Conference
    • Place of Presentation
      北京(中国)
    • Year and Date
      2015-05-11
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ショウジョウバエ胚中腸におけるHOX遺伝子Antp の働き2014

    • Author(s)
      田上和、藤本啓太、有重昌彦、原田由美子、村上柳太郎
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Research-status Report
  • [Presentation] ショウジョウバエアデニル酸キナーゼ2(AK2)の時期特異的ノックダウンによる影響2014

    • Author(s)
      青山修平、堀口大吾、野間隆文、原田由美子、村上柳太郎
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Research-status Report
  • [Presentation] Role of HOX genes in the pattern formation of Drosophila midgut2014

    • Author(s)
      Yuichi Yoshimura, Yumiko Harada, Keita Fujimoto, Masahiko Arishige, Ryutaro Murakami
    • Organizer
      第47回日本発生生物学会
    • Place of Presentation
      WINC AICHI(名古屋)
    • Year and Date
      2014-05-27 – 2014-05-30
    • Related Report
      2014 Research-status Report
  • [Presentation] アデニル酸キナーゼ2の時期特異的ノックダウン2014

    • Author(s)
      青山修平, 深美由紀, 堀口大悟, 野間隆文,原田由美子,村上柳太郎
    • Organizer
      中国四国地区生物系三学会合同大会(岡山大会)
    • Place of Presentation
      岡山理科大学(岡山)
    • Year and Date
      2014-05-10 – 2014-05-11
    • Related Report
      2014 Research-status Report
  • [Presentation] The HOX gene Antp in the visceral mesoderm Drosophila regulates size balance between 1st and 2nd midgut chambers2013

    • Author(s)
      Keita Fujimoto, Masahiko Arishige, Yumiko Harada, Ryutaro Murakami
    • Organizer
      第46回日本発生生物学会
    • Place of Presentation
      国引きメッセ(松江)
    • Related Report
      2013 Research-status Report
  • [Presentation] drumstick , a Drosophila odd-family gene, regulates pattern formation around the midgut/ hindgut boundary2013

    • Author(s)
      Chihiro Yokota, Sarder N. Uddin, Ryutaro Murakami
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド(神戸)
    • Related Report
      2013 Research-status Report
  • [Presentation] Function of a HOX gene Antp in the midgut of Drosophila2013

    • Author(s)
      Izumi Tanoue, Keita Fujimoto , Masahiko Arishige, Yumiko Harada, Ryutaro Murakami
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド(神戸))
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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