HOX genes regulate size balance between regions of digestive tract
| Project/Area Number |
25440111
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Developmental biology
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| Research Institution | Yamaguchi University |
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Principal Investigator |
MURAKAMI RYUTARO 山口大学, 医学(系)研究科(研究院), 教授 (40182109)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | HOX genes / Drosophila / midgut / visceral mesoderm / size control / Dpp / EGFR / HOX / visceral / mesoderm / chamber / size / ショウジョウバエ / 中腸 / 内臓筋 / EGFシグナル |
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| Outline of Final Research Achievements |
The midgut of Drosophila embryo consists of endodermal epithelium and visceral mesoderm, and transiently forms four chambers during development. HOX genes, Scr , Antp , Ubx , and abd-A , are expressed in the midgut visceral mesoderm. We have studied role of HOX genes in the development of midgut chambers by use of chamber-specific epithelial differentiation markers. It was found that except for differentiation of the 2nd chamber, HOX genes are not required for chamber-specific epithelial differentiation itself. Antp, which is expressed at the boundary between the 1st and 2nd chambers, regulates size of the both chambers. Antp activity was found to be mediated by EGFR signaling pathway, and all the phenotypes caused by genetic modification of Antp activity were all associated with changes in dpp expression.
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Report
(4 results)
Research Products
(12 results)
