Plasticity of the basic developmental mechanism of chordate as observed in ascidians
Project/Area Number |
25440113
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Developmental biology
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Research Institution | Tokyo Metropolitan University |
Principal Investigator |
Saiga Hidetoshi 首都大学東京, 理工学研究科, 客員教授 (60131918)
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Project Period (FY) |
2013-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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Keywords | ホヤ / Hox / Otx / マボヤ / カタユウレイボヤ / Hox遺伝子 / クラスター / 進化 / 消化管 / 内胚葉索 / Hoxクラスター / 転写 / 中枢神経系 / Hox10 / Kaede |
Outline of Final Research Achievements |
Ascidians, a closest animal group to vertebrates, are classified into 2 groups. Ciona intestinalis (Ci) and Halocynthia roretzi (Hr) are popular ascidian species belonging to the distinct groups. However, they exhibit very similar development to form tadpole larvae. The present study focused on the Hox and Otx, which play pivotal roles in anterior-posterior and anterior patterning, respectively. We have shown the Hox gene complement and cluster structure of Hr. The Hr Hox gene complement consisted of 9 members like in Ci, and the Hr Hox gene cluster is disintegrated in Hr but in a different manner from that in Ci. As regards developmental changes in the gene regulatory mechanisms of Otx, we have found that regulatory mechanisms change as development proceeds, but the way of the change is distinct between Hr and Ci. Thus, the different genetic mechanisms produce a similar outputs, development and expression pattern, in phylogenetically remote ascidians.
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Report
(6 results)
Research Products
(21 results)
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[Journal Article] Transcriptional regulation of a horizontally transferred gene from bacterium to chordate.2016
Author(s)
Sasakura Y, Ogura Y, Treen N, Yokomori R, Park SJ, Nakai K, Saiga H, Sakuma T, Yamamoto T, Fujiwara S, Yoshida K.
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Journal Title
Proc Biol Sci.
Volume: 283
Issue: 1845
Pages: 20161712-20161712
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Identical genomic organization of two hemichordate hox clusters.2012
Author(s)
Freeman R, Ikuta T, Wu M, Koyanagi R, Kawashima T, Tagawa K, Humphreys T, Fang GC, Fujiyama A, Saiga H, Lowe C, Worley K, Jenkins J, Schmutz J, Kirschner M, Rokhsar D, Satoh N, Gerhart J.
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Journal Title
Current Biology
Volume: 22
Issue: 21
Pages: 2053-2058
DOI
Related Report
Peer Reviewed
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[Presentation] Formation of the digestive tract in Ciona intestinalis includes distinct morphogenetic processes between its anterior and posterior parts.2015
Author(s)
Nakazawa, K., Yamazawa, T., Moriyama, Y.,Ogura, Y., Kawai, N., Sasakura, Y. and Saiga, H.
Organizer
The 8th International Tunicate Meeting
Place of Presentation
Aomori
Year and Date
2015-07-13
Related Report
Int'l Joint Research
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[Presentation] Hox gene cluster structure in Halocynthia roretzi genome.2015
Author(s)
Sekigami, Y., Kobayashi, T., Omi, A., Ikuta, T., Fujiyama, A., Satoh, N. and Saiga, H.
Organizer
The 48th Annual Meeting of the Japanese Society of Developmental Biologists
Place of Presentation
筑波
Year and Date
2015-06-02
Related Report
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[Presentation] Hox gene cluster structure in the genome of Halocynthia roretzi.2013
Author(s)
Sekigami, Y., Kobayashi,T., Omi, A., Ikuta, T., Fujiyama, A., Satoh, N. and Saiga, H.
Organizer
The 46th Annual Meeting of the Japanese Society of Developmental Biologists
Place of Presentation
Matsue
Related Report
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[Presentation] Formation of the digestive tract in Ciona intestinalis includes two distinct morphogenic processes between its anterior and posterior parts.2013
Author(s)
Nakazawa, K., Yamazawa, T., Moriyama, Y., Ogura, Y., Kawai, N., Sasakura, Y. and Saiga, H.
Organizer
The 46th Annual Meeting of the Japanese Society of Developmental Biologists
Place of Presentation
Matsue
Related Report
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