| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
Organs consist of cells. I would like to elucidate formation process of chiral structures of organs using cell-based mathematical models of tissues. Hearts in the early development of birds and mammals are known to form chiral structure, a helical loop. I showed that a simple straight tube of the initial heart makes a helical loop by (1) bending accompanying ventral protrusion of the tube and (2) dividing cells perform a chiral behavior, that is, counter-clockwise rotation of two daughter cells. The problem of cardiac looping made progress to a problem that cell chiral behavior is an intrinsic cell properties or caused by asymmetric circumference of the animal body.
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