Bone remodeling process for the lateral line scale in zebrafish

• Project/Area Number: 25440118
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Developmental biology
• Research Institution: 大学共同利用機関法人情報・システム研究機構(新領域融合研究センター及びライフサイエンス統合データベースセンター)
• Principal Investigator: Wada Hironori 大学共同利用機関法人情報・システム研究機構(新領域融合研究センター及びライフサイ, 新領域融合研究センター, 融合プロジェクト研究員 (70322708)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 骨リモデリング / 側線鱗 / ゼブラフィッシュ / 骨芽細胞 / 破骨細胞 / 側線神経

Outline of Final Research Achievements

Bones are continuously renewed through a bone remodeling process in a homeostatic manner. Defects in the bone remodeling process cause bone diseases such as osteoporosis. To understand mechanisms of bone remodeling, we studied the development of lateral line scales in zebrafish. The lateral line canal system is located within scales (dermal bone) running under the skin. We demonstrated that canals originate from scales through a bone remodeling process. Moreover, we found that lateral line sensory organs are required for the formation of canals, suggesting the existence of mutual interactions between the neural tissue and surrounding connective tissues (Wada et al., 2014).

Research Products

• [Journal Article] Size control during organogenesis: Development of the lateral line organs in zebrafish (2015)
  • Author(s): Wada, H. and Kawakami, K.
  • Journal Title: Development, Growth and Differentiation Volume: 57 Issue: 2 Pages: 169-178
  • DOI: 10.1111/dgd.12196
  • Peer Reviewed
• [Journal Article] 神経組織による骨リモデリングの制御 (2015)
  • Author(s): 和田浩則
  • Journal Title: 化学と生物 Volume: 53 Pages: 76-77
• [Journal Article] Development of the lateral line canal system through a bone remodeling process in zebrafish (2014)
  • Author(s): Wada, H., Iwasaki, M., and Kawakami, K.
  • Journal Title: Developmental Biology Volume: 392 Issue: 1 Pages: 1-14
  • DOI: 10.1016/j.ydbio.2014.05.004
  • Peer Reviewed
• [Journal Article] Innervation is required for sense organ development in the lateral line system of adult zebrafish (2013)
  • Author(s): Wada, H., Dambly-Chaudiere, C., Kawakami, K., and Ghysen, A.
  • Journal Title: Proc. Natl. Acad. Sci. USA Volume: 110 Issue: 14 Pages: 5659-5664
  • DOI: 10.1073/pnas.1214004110
  • Peer Reviewed
• [Journal Article] Wnt/Dkk negative feedback regulates sensory organ size in zebrafish (2013)
  • Author(s): Wada, H., Ghysen, A., Asakawa, K., Abe, G., Ishitani, T., and Kawakami, K.
  • Journal Title: Current Biology Volume: 23 Issue: 16 Pages: 1559-1565
  • DOI: 10.1016/j.cub.2013.06.035
  • Peer Reviewed
• [Presentation] 魚類側線器官の発生と進化 (2014)
  • Author(s): 和田浩則
  • Organizer: 第４回 Tokyo Vertebrate Morphology Meeting
  • Place of Presentation: 東京
  • Year and Date: 2014-07-12
  • Invited
• [Presentation] Development of the lateral line canal system through a bone remodeling process in zebrafish (2014)
  • Author(s): Wada H, Kawakami K
  • Organizer: 第47回 日本発生生物学会
  • Place of Presentation: 名古屋
  • Year and Date: 2014-05-27 – 2014-05-30
• [Presentation] Development of the lateral line canal system in zebrafish (2013)
  • Author(s): Wada H, Kawakami K
  • Organizer: The 19th Japanese Medaka and zebrafish meeting
  • Place of Presentation: 仙台
• [Presentation] Development of the trunk lateral line system through a bone remodeling process in zebrafish (2013)
  • Author(s): Wada H, Kawakami K
  • Organizer: 第４６回 日本発生生物学会
  • Place of Presentation: 松江
• [Book] Flow Sensing in Air and Water - Behavioural, Neural and Engineering Principles of Operation (2014)
  • Author(s): Ghysen A, Wada H, Dambly-Chaudiere C
  • Total Pages: 562
  • Publisher: Springer-Verlag.
• [Remarks] ようこそ和田のホームページへ
  • URL: http://w01.tp1.jp/~a680124941/Wadas_home_page/homu.html
• [Remarks] ようこそ和田のホームページへ
  • URL: http://w01.tp1.jp/~a680124941/Wadas_home_page/homu.html