| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
In the small intestine of Xenopus laevis during metamorphosis, which is caused by thyroid hormone (TH), most of the larval epithelial cells are removed by apoptosis whereas some cells dedifferentiate into the adult epithelial stem cells. They actively proliferate and differentiate to form the adult epithelium.
We found that during this intestinal remodeling, Notch signaling pathway is activated by TH and that inhibition of this pathway inhibits TH-induced up-regulation of Notch response gene and, more importantly, LGR5, an adult intestinal stem cell marker gene. In addition, inhibition of Notch suppressed differentiation of the stem cells into the absorptive epithelial cells, but facilitated their differentiation into the secretory epithelial cells. Our results suggest that Notch signaling plays important roles in the intestinal remodeling.
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