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Regulation of folliculegenesis by brain/gut peptides in Ciona intestinalis

Research Project

Project/Area Number 25440161
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Morphology/Structure
Research InstitutionSuntory Foundation for Life Sciences

Principal Investigator

Satake Honoo  公益財団法人サントリー生命科学財団, その他部局等, 主幹研究員 (20280688)

Co-Investigator(Renkei-kenkyūsha) KAWADA Tsuyoshi  公益財団法人サントリー生命科学財団, 生物有機科学研究所, 主席研究員 (90300821)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsペプチド / カタユウレイボヤ / 卵胞成長 / 進化 / ホヤ / 脳腸ペプチド / 卵胞 / Wnt / in situ hybridization / RNA-Seq
Outline of Final Research Achievements

In this study, we identified a receptor for Ci-GALP, which is an Ciona intestin ortholog of vertebrate galanin/GALP. We also localized the mRNA ofreceptors for Ci-GALP, cionin, and GrRH, respectivly. RNA-Seq follwed by real-time PCR for the Ciona follicles treated with each peptide revealed the gene expression profile. Moreover, the inhibitors of the regulated gene product suppress follicle grwoth in a ligand-specific manner. Taken together, these results substantiated the essentila molecular mechanisms of Ciona follicle grwoth regulated bu brain/gut peptides. These are the first reports on the biological roles of these brain/gut peptide in the ovary in an organism.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (28 results)

All 2016 2015 2014 2013 Other

All Journal Article (15 results) (of which Peer Reviewed: 15 results,  Open Access: 6 results,  Acknowledgement Compliant: 3 results) Presentation (12 results) (of which Invited: 4 results) Remarks (1 results)

  • [Journal Article] Evidence for conservation of the calcitonin superfamily and activity-regulating mechanisms in the basal chordate Branchiostoma floridae: insight into the molecular and functional evolution in chordates.2016

    • Author(s)
      Sekiguchi, T., Kuwasako, K., Ogasawara, M., Takahashi, H., Matsubara, S., Osugi, T., Muramatsu, I., Sasayama, Y., Suzuki, N., and Satake, H.
    • Journal Title

      J. Biol. Chem.

      Volume: 291 Issue: 5 Pages: 2345-2356

    • DOI

      10.1074/jbc.m115.664003

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Matsubara S, Kawada T, Sakai T, Aoyama M, Osugi T, Shiraishi A, Satake H.2016

    • Author(s)
      The significance of Ciona intestinalis as a stem organism in integrative studies of functional evolution of the chordate endocrine, neuroendocrine, and nervous systems.
    • Journal Title

      Gen Comp Endocrinol.

      Volume: 227 Pages: 101-108

    • DOI

      10.1016/j.ygcen.2015.05.010

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Generation of Triple-Transgenic Forsythia Cell Cultures as a Platform for the Efficient, Stable, and Sustainable Production of Lignans.2015

    • Author(s)
      2.Murata J, Matsumoto E, Morimoto K, Koyama T, Satake H.
    • Journal Title

      PLOS One

      Volume: 10 Issue: 12 Pages: e0144519-e0144519

    • DOI

      10.1371/journal.pone.0144519

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Characterization of GnRH-like peptides from the nerve ganglia of Yesso scallop, Patinopecten yessoensis.2015

    • Author(s)
      Nagasawa, K, Osugi, T, Suzuki I, Itoh N, Takahashi KG, Satake H, Osada M
    • Journal Title

      Peptides

      Volume: 71 Pages: 202-210

    • DOI

      10.1016/j.peptides.2015.07.022

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Effect of Chitosan and Chitin Oligomers on Gene Expression and Lignan Production in Linum album Cell Cultures.2014

    • Author(s)
      Bahabadi, S.E., Sharifi, M., Murata, J. Satake, H.
    • Journal Title

      J. Med. Plant.

      Volume: 13 Pages: 46-53

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A conserved noncoding sequence can function as a spermatocyte-specific enhancer and a bidirectional promoter for a ubiquitously expressed gene and a testis-specific long noncoding RNA.2014

    • Author(s)
      Kurihara, M., Shiraishi, A., Satake, H., Kimura A.P.
    • Journal Title

      J. Mol. Biol.

      Volume: 426 Issue: 17 Pages: 3069-3093

    • DOI

      10.1016/j.jmb.2014.06.018

    • NAID

      120005476218

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Nonreproductive role of gonadotropin-releasing hormone in the control of ascidian metamorphosis.2014

    • Author(s)
      Kamiya C, Ohta N, Ogura Y, Yoshida K, Horie T, Kusakabe TG, Satake H, Sasakura Y.
    • Journal Title

      Developmental Dynamics

      Volume: 243 Issue: 12 Pages: 1524-1535

    • DOI

      10.1002/dvdy.24176

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Significant enhancement of lignans accumulation in hairy root cultures of Linum album using biotic elicitors2014

    • Author(s)
      Bahabadi, S.E., Sharifi, M., Chashmi, N.A. Murata, J. Satake, H.
    • Journal Title

      Acta Physiol. Plant.

      Volume: 36 Issue: 12 Pages: 3325-3331

    • DOI

      10.1007/s11738-014-1700-z

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Draft Genome of Hop (Humulus lupulus), an Essence for Brewing.2014

    • Author(s)
      Natsume, S., Takagi, H., Shiraishi, A., Murata, J., Toyonaga, H., Patzak, J., Takagi, M., Yaegashi, H., Uemura, A., Mitsuoka, C., Yoshida, K., Krofta, K., Satake, H., Terauchi, R., Ono, E.
    • Journal Title

      Plant Cell Physiol.

      Volume: 56 Issue: 3 Pages: 428-441

    • DOI

      10.1093/pcp/pcu169

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Seasonal Alteration in Amounts of Lignans and Their Glucosides and Gene Expression of the Relevant Biosynthetic Enzymes in the <i>Forsythia suspense</i> Leaf2013

    • Author(s)
      Morimoto, K., Satake, H.
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 36 Issue: 9 Pages: 1519-1523

    • DOI

      10.1248/bpb.b13-00437

    • NAID

      130003361535

    • ISSN
      0918-6158, 1347-5215
    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Germline transgenesis of the chordate Ciona intestinalis with hyperactive variants of sleeping beauty transposable element.2013

    • Author(s)
      Akiko Hozumi
    • Journal Title

      Developmental Dynamics

      Volume: 242 Issue: 1 Pages: 30-43

    • DOI

      10.1002/dvdy.23891

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] The pars intercerebralis affects digestive activities of the American cockroach, Periplaneta americana, via crustacean cardioactive peptide and allatostatin-A.2013

    • Author(s)
      Matsui, T., Sakai, T., Satake, H., Takeda M.
    • Journal Title

      J. Insect Physiol.

      Volume: 59 Issue: 1 Pages: 33-37

    • DOI

      10.1016/j.jinsphys.2012.06.010

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] GPCR Heterodimerization in the Reproductive System: Functional Regulation and Implication for Biodiversity.2013

    • Author(s)
      Satake H, Matsubara S, Aoyama M, Kawada T, Sakai T.
    • Journal Title

      Front Endocrinol

      Volume: 4 Pages: 100-100

    • DOI

      10.3389/fendo.2013.00100

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Recent advances in metabolic engineering of lignan biosynthesis pathways for the production of transgenic plant-based foods and supplements2013

    • Author(s)
      Satake, H., Ono, E., Murata, J.
    • Journal Title

      J. Agric. Food Chem.

      Volume: 61 Issue: 48 Pages: 11721-11729

    • DOI

      10.1021/jf4007104

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Insight into Molecular and Functional Diversity of Tachykinins and their Receptors.2013

    • Author(s)
      Satake, H., Aoyama, M., Sekiguchi, T., Kawada, T.
    • Journal Title

      Protein & Peptide Letters

      Volume: 20 Issue: 6 Pages: 615-627

    • DOI

      10.2174/0929866511320060002

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] カタユウレイボヤを起点とした脊索動物門に共通する卵胞制御機構の新展開2015

    • Author(s)
      佐竹炎
    • Organizer
      第86回日本動物学会
    • Place of Presentation
      新潟
    • Year and Date
      2015-09-17
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] GnRH promotes ovarian follicular growth in Ciona intestinalis2014

    • Author(s)
      松原、白石、佐竹
    • Organizer
      第39回日本比較内分泌学会大会
    • Place of Presentation
      岡崎
    • Year and Date
      2014-11-07 – 2014-11-09
    • Related Report
      2014 Research-status Report
  • [Presentation] The distribution of multiple neuropeptides were visualized in the brain of Ciona intestinalis by imaging mass spectrometry.2014

    • Author(s)
      大杉、川田、佐竹
    • Organizer
      第39回日本比較内分泌学会大会
    • Place of Presentation
      岡崎
    • Year and Date
      2014-11-07 – 2014-11-09
    • Related Report
      2014 Research-status Report
  • [Presentation] 脊索動物門で保存されている新規卵胞制御機構の共通性と多様性の解明2014

    • Author(s)
      佐竹
    • Organizer
      日本動物学会第85回大会
    • Place of Presentation
      仙台
    • Year and Date
      2014-09-11 – 2014-09-13
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 成長途上のカタユウレイボヤ卵巣におけるホヤバソプレシン遺伝子の発現解析2014

    • Author(s)
      川田、堀江、笹倉、小笠原、佐竹
    • Organizer
      日本動物学会第85回大会
    • Place of Presentation
      仙台
    • Year and Date
      2014-09-11 – 2014-09-13
    • Related Report
      2014 Research-status Report
  • [Presentation] ホヤのコレシストキニン/ガストリンホモログcioninの卵巣における機能解析2014

    • Author(s)
      大杉、白石、佐竹
    • Organizer
      日本動物学会第85回大会
    • Place of Presentation
      仙台
    • Year and Date
      2014-09-11 – 2014-09-13
    • Related Report
      2014 Research-status Report
  • [Presentation] GPCRヘテロダイマーの半網羅的検出方法の確立2014

    • Author(s)
      松原、酒井、佐竹
    • Organizer
      日本動物学会第85回大会
    • Place of Presentation
      仙台
    • Year and Date
      2014-09-11 – 2014-09-13
    • Related Report
      2014 Research-status Report
  • [Presentation] 脊索動物門における生殖内分泌系の共通性と多様性に迫る-ホヤのペプチドホルモン研究を出発として-2013

    • Author(s)
      佐竹、川田、宮坂、大杉、松原、白石、青山、安田
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Differential regulation of GnRH signalling cascades via heterodimerization among multiple GnRH receptor palarogs in the ascidian, Ciona intestinalis.2013

    • Author(s)
      Satake H
    • Organizer
      17th International Congress of Comparative Endocrinology
    • Place of Presentation
      Barcelona
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] マウスにおいてタキキニンは二次卵胞成長を促進する2013

    • Author(s)
      青山、川田、伊丹、保、安田、佐竹
    • Organizer
      第38回日本比較内分泌学会大会
    • Place of Presentation
      宮崎
    • Related Report
      2013 Research-status Report
  • [Presentation] トランスジェニック体を用いたカタユウレイボヤのオキシトシン/バソプレシン遺伝子の発現解析2013

    • Author(s)
      川田、堀江、笹倉、小笠原、佐竹
    • Organizer
      日本動物学会第84回大会
    • Place of Presentation
      岡山
    • Related Report
      2013 Research-status Report
  • [Presentation] GPCRに普遍的な相互作用パターン抽出による生物種ワイドな相互作用予測法の開発2013

    • Author(s)
      白石、佐竹
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Related Report
      2013 Research-status Report
  • [Remarks]

    • Related Report
      2015 Annual Research Report

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Published: 2014-07-25   Modified: 2019-07-29  

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