Regulation of folliculegenesis by brain/gut peptides in Ciona intestinalis
Project/Area Number |
25440161
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Morphology/Structure
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Research Institution | Suntory Foundation for Life Sciences |
Principal Investigator |
Satake Honoo 公益財団法人サントリー生命科学財団, その他部局等, 主幹研究員 (20280688)
|
Co-Investigator(Renkei-kenkyūsha) |
KAWADA Tsuyoshi 公益財団法人サントリー生命科学財団, 生物有機科学研究所, 主席研究員 (90300821)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | ペプチド / カタユウレイボヤ / 卵胞成長 / 進化 / ホヤ / 脳腸ペプチド / 卵胞 / Wnt / in situ hybridization / RNA-Seq |
Outline of Final Research Achievements |
In this study, we identified a receptor for Ci-GALP, which is an Ciona intestin ortholog of vertebrate galanin/GALP. We also localized the mRNA ofreceptors for Ci-GALP, cionin, and GrRH, respectivly. RNA-Seq follwed by real-time PCR for the Ciona follicles treated with each peptide revealed the gene expression profile. Moreover, the inhibitors of the regulated gene product suppress follicle grwoth in a ligand-specific manner. Taken together, these results substantiated the essentila molecular mechanisms of Ciona follicle grwoth regulated bu brain/gut peptides. These are the first reports on the biological roles of these brain/gut peptide in the ovary in an organism.
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Report
(4 results)
Research Products
(28 results)
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[Journal Article] Evidence for conservation of the calcitonin superfamily and activity-regulating mechanisms in the basal chordate Branchiostoma floridae: insight into the molecular and functional evolution in chordates.2016
Author(s)
Sekiguchi, T., Kuwasako, K., Ogasawara, M., Takahashi, H., Matsubara, S., Osugi, T., Muramatsu, I., Sasayama, Y., Suzuki, N., and Satake, H.
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Journal Title
J. Biol. Chem.
Volume: 291
Issue: 5
Pages: 2345-2356
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] The Draft Genome of Hop (Humulus lupulus), an Essence for Brewing.2014
Author(s)
Natsume, S., Takagi, H., Shiraishi, A., Murata, J., Toyonaga, H., Patzak, J., Takagi, M., Yaegashi, H., Uemura, A., Mitsuoka, C., Yoshida, K., Krofta, K., Satake, H., Terauchi, R., Ono, E.
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Journal Title
Plant Cell Physiol.
Volume: 56
Issue: 3
Pages: 428-441
DOI
Related Report
Peer Reviewed / Open Access
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