| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
We have previously reported that LTM formation ability of crickets decline along with aging. In the present study, I demonstrated how three types of candidate life-span extending treatments affect the actual life-span and ability of LTM formation in crickets. Rearing the crickets under a low-temperature environment lead to extension in life-span along with sustained LTM formation ability. Mating restriction also extended the life-span but with impairment in LTM formation ability much earlier than the control group. Chronic administration of melatonin did not significantly extend the life-span, but LTM formation ability was conserved longer. I also found that single-injection of melatonin recovered the LTM formation ability in aged crickets, indicating the participation of melatonin in LTM formation process.
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