Molecular basis of memory impairment related to life-span extending treatments in insect
Project/Area Number |
25440163
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Animal physiology/Animal behavior
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Research Institution | Tokyo Medical and Dental University |
Principal Investigator |
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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Keywords | 加齢性記憶障害 / 嗅覚学習 / 長期記憶 / 一酸化窒素 / メラトニン / 昆虫 / コオロギ |
Outline of Final Research Achievements |
We have previously reported that LTM formation ability of crickets decline along with aging. In the present study, I demonstrated how three types of candidate life-span extending treatments affect the actual life-span and ability of LTM formation in crickets. Rearing the crickets under a low-temperature environment lead to extension in life-span along with sustained LTM formation ability. Mating restriction also extended the life-span but with impairment in LTM formation ability much earlier than the control group. Chronic administration of melatonin did not significantly extend the life-span, but LTM formation ability was conserved longer. I also found that single-injection of melatonin recovered the LTM formation ability in aged crickets, indicating the participation of melatonin in LTM formation process.
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Report
(4 results)
Research Products
(28 results)
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[Journal Article] Participation of NO signaling in formation of long-term memory in salivary conditioning of the cockroach.2013
Author(s)
Matsumoto, C.S., Kuramochi, T., Matsumoto, Y., Watanabe, H., Nishino, H., Mizunami, M.
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Journal Title
Neuroscience Letters
Volume: 印刷中
Pages: 4-8
DOI
NAID
Related Report
Peer Reviewed
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