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Study on the Bio-inspired electric nose and odor-coding theory

Research Project

Project/Area Number 25440164
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Animal physiology/Animal behavior
Research InstitutionMuroran Institute of Technology

Principal Investigator

IWASA Tatsuo  室蘭工業大学, 工学(系)研究科(研究院), 教授 (00133926)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords匂い分子結合タンパク質 / 化学感覚タンパク質 / バイオ化学センサー / 生体機能指向型エレクトリックノーズ / レイリー型表面弾性波センサー / FETセンサー / 遺伝子改変タンパク質発現 / タンパク質匂いセンサー素子 / 生体機能志向型エレクトリックノーズ / レイリー型表面弾性はセンサー / 匂い分別 / レイリー波 / 表面弾性波 / SAWデバイス / 電子鼻 / リポカリン / 部位特異的変異導入 / Chemosensory Protein
Outline of Final Research Achievements

This research project aims to make a prototype of a bio-inspired electric nose, which can detect different types of odorant molecules and distinguish them. In order to use the sensing-element of the electric nose, we plan to use odorant binding proteins of Japanese common newt, Cp-Lip1 and -Lip2 which we found and chemosensory proteins (CSPs) found in the sensillum of carpenter ant, Camponotus japonicus. The expression and purification system of the proteins from E. coli expression systems were established.The purified proteins retained their native secondary structure and binding properties. The amino acid replacement of Cp-Lip1 changed its odorant binding properties, which enable to obtain odorant-sensor elements of the different odorant-binding capacity. These sensor elements were fixed and used on a prototype of a surface acoustic wave (SAW) sensor and a field effect transistor (FET) sensor.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (33 results)

All 2016 2015 2014 2013 Other

All Journal Article (18 results) (of which Peer Reviewed: 18 results,  Open Access: 4 results,  Acknowledgement Compliant: 1 results) Presentation (13 results) (of which Int'l Joint Research: 2 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Development of the Rayleigh Type Surface Acoustic Wave Sensor Liquid Phase System Using a Longitudinal Wave Radiation into a Liquid Phase2015

    • Author(s)
      4)K. Ogawa, T. Torigoe, K. Sawada, T. Iwasa, K. Nagano, Y. Shibayama, Y. Tada, K. Uesugi, H. Fukuda
    • Journal Title

      IEEJ Transactions on Sensors and Micromachines

      Volume: 135 Issue: 12 Pages: 490-495

    • DOI

      10.1541/ieejsmas.135.490

    • NAID

      130005112395

    • ISSN
      1341-8939, 1347-5525
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Study on the structure and binding properties of CSP1 and CSP3 from Camponotus Japonicas.2015

    • Author(s)
      Wendurige, Xing Li, Masaru Hojo, Mamiko Ozaki and Tatsuo Iwasa
    • Journal Title

      Jpn. J. Taste Smell Res.

      Volume: 22 Pages: 425-428

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The effect of structural fluctuations on the ligand-binding property of odorant-binding protein of Japanese common newt.2015

    • Author(s)
      Xing Li, Wendurige, Ken Sawada and Tatsuo Iwasa
    • Journal Title

      Jpn. J. Taste Smell Res.

      Volume: 22 Pages: 423-424

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In situ Ca2+ imaging of the different ring structure of the odorant molecules response in the olfactory epithelium of the Japanese common newt.2015

    • Author(s)
      Naoyuki Umeda, Soitiro Inomata, Hirofumi Sugimoto, Tatsuo Iwasa and Ken Sawada
    • Journal Title

      Jpn. J. Taste Smell Res.

      Volume: 22 Pages: 443-446

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Microbial rhodopsins of Halorubrum species isolated from Ejinoor salt lake in Inner Mongolia of China2015

    • Author(s)
      Chaoluomeng, Gang Dai, Takashi Kikukawa, Kunio Ihara and Tatsuo Iwasa
    • Journal Title

      Photochemical & Photobiological Sciences

      Volume: 14 Issue: 11 Pages: 1974-1982

    • DOI

      10.1039/c5pp00161g

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Magnetic properties of magnetite synthesized by Magnetospirillum magnetotacticum MS-1 cultured at different concentrations of ferric iron2015

    • Author(s)
      iriletu and T. Iwasa
    • Journal Title

      Biotechnology Letters

      Volume: 37 Issue: 12 Pages: 2427-2433

    • DOI

      10.1007/s10529-015-1928-8

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The study on the structural changes and ligand binding of Cp-Lip12014

    • Author(s)
      Li X, Wendurige, Sawada K, and Iwasa T.
    • Journal Title

      Jap. J. Taste Smell Res.

      Volume: 21 Pages: 415-418

    • NAID

      110009892326

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] The structure-function studies on chemosensory protein found in the sensilium of Camponotus japonicus2014

    • Author(s)
      Wendurige, Li X, Hojo M, Ozaki M, and Iwasa T.
    • Journal Title

      Jap. J. Taste Smell Res.

      Volume: 21 Pages: 419-422

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Analysis of the odorant binding properties of the olfactory receptor neurons in the Japanese common newt2014

    • Author(s)
      Sugimoto H, Umeda N, Fukuda H, Iwasa T, and Sawada K.
    • Journal Title

      Jap. J. Taste Smell Res.

      Volume: 21 Pages: 437-440

    • NAID

      110009892332

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Electrical properties of liquid phase sensor using Rayleigh type surface acoustic wave.2014

    • Author(s)
      Ogawa K, Yamada S, Torigoe T, Sawada K, Iwasa T, Sugiyama F, Tada Y, Uesugi K, and Fukuda H.
    • Journal Title

      J. Surf. Sci. Soc. Jap.

      Volume: 35 Pages: 319-323

    • NAID

      130004718849

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Enantioselective diels-alder reaction of 1,2-dihydropyridines with aldehydes using beta-amino alcohol organocatalyst2014

    • Author(s)
      Kohari Y, Okuyama Y, Kwon E, Furuyama T, Kobayashi N, Otuki T, Kumagai J, Seki C, Uwai K, Dai G, Iwasa T, Nakano H
    • Journal Title

      J Org Chem

      Volume: 79 Issue: 20 Pages: 9500-9511

    • DOI

      10.1021/jo501433c

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Photocatalytic degradiation of phenol with bacteriorhodopsin sensitized TiO2 nanoparticles2014

    • Author(s)
      Dai G, Chaoluomeng, Iwasa T
    • Journal Title

      Adv. Mat. Res.

      Volume: 955-959 Pages: 415-418

    • DOI

      10.4028/www.scientific.net/amr.955-959.415

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] 縦波表面弾性波を用いた液相系センサーの動作特性2014

    • Author(s)
      小川健吾、山田真也、鳥越俊彦、澤田研、岩佐達郎、杉山史一、夛田芳宏、上杉克弘、福田永
    • Journal Title

      表面科学

      Volume: in press

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] イモリ嗅上皮に発現する「匂い分子結合タンパク質」のシステイン残基の働き2013

    • Author(s)
      李興、大塚淳哉、澤田研、福田永、夛田芳宏、岩佐達郎
    • Journal Title

      日本味と匂学会誌

      Volume: 20巻3号 Pages: 351-354

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 匂い分子結合タンパク質Cp-Lip1のバレル内腔に存在するアミノ酸残基の匂い分子結合に関わる役割2013

    • Author(s)
      杉浦康裕、鳥井綾乃、杉本弘文、岩佐達郎、福田永、澤田研
    • Journal Title

      日本味と匂学会誌

      Volume: 20巻3号 Pages: 359-362

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 匂い分子結合タンパク質Cp-Lip1のバレル構造の入り口付近に存在するアミノ酸残基の匂い分子結合に関わる役割2013

    • Author(s)
      鈴木里奈、杉浦康裕、鳥井綾乃、杉本弘文、岩佐達郎、福田永、澤田研
    • Journal Title

      日本味と匂学会誌

      Volume: 20巻3号 Pages: 355-358

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Isolation and genetic characterization of phenol-degradating bacterium from a salt lake in Inner Mongolia2013

    • Author(s)
      Gang Dai, Lamei Liu, Quingchao Ouyang, Chaoluomeng, Tatsuo Iwasa
    • Journal Title

      Advanced Materials Research

      Volume: 726-731 Pages: 396-400

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cp-Lip1タンパク質の有無による嗅神経細胞の匂い応答の違い2013

    • Author(s)
      杉本弘文、杉浦康裕、福田永、岩佐達郎、澤田研
    • Journal Title

      日本味と匂学会誌

      Volume: 20巻3号 Pages: 373-376

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] The structure-function relationships of chemosensory protein found in the sensillum of Camponotus japonicus.2016

    • Author(s)
      Wendurige, Xing Li, Masaru Hojo, Mamiko Ozaki and Tatsuo Iwasa
    • Organizer
      Joint Seminar on Environmental Science and Disaster Mitigation Research 2016
    • Place of Presentation
      Muroran, Japan
    • Year and Date
      2016-03-11
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] アデノシン三リン酸(ATP)水溶液におけるレイリー型SAW溝流路液相系センサーの動作特性2015

    • Author(s)
      小川 健吾,  山田 真也,  菅原 智明,  岩佐 達郎,  夛田 芳広, 福田 永
    • Organizer
      第76回応用物理学会秋季学術講演会
    • Place of Presentation
      名古屋、日本
    • Year and Date
      2015-09-13
    • Related Report
      2015 Annual Research Report
  • [Presentation] Structural and functional studies on two kinds of perireceptor proteins (PRPs) working in chemoreception2015

    • Author(s)
      Xing Li, Durige Wen, Masaru Hojo, Mamiko Ozaki, Tatsuo Iwasa
    • Organizer
      第53回日本生物物理学会
    • Place of Presentation
      金沢、日本
    • Year and Date
      2015-09-13
    • Related Report
      2015 Annual Research Report
  • [Presentation] The structural change of the perireceptor proteins, OBP and CSP, upon ligand binding2015

    • Author(s)
      Xing Li, Wendurige, Masaru Hojo, Mamiko Ozaki, Tatsuo Iwasa
    • Organizer
      The 9th International Congressof Comparative Physiology and Biochemistry
    • Place of Presentation
      Krakow, Poland
    • Year and Date
      2015-08-23
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] イモリCp-Lip1のリガンド結合と構造変化の解析2014

    • Author(s)
      李興、温都日格、福田永、澤田研、岩佐達郎
    • Organizer
      日本味と匂学会第48回大会
    • Place of Presentation
      清水文化会館マリナート(静岡県静岡市清水区)
    • Year and Date
      2014-10-02 – 2014-10-04
    • Related Report
      2014 Research-status Report
  • [Presentation] アリの感覚子に発現する「化学感覚タンパク質」の構造機能解析2014

    • Author(s)
      温都日格、李興、北條賢、尾崎まみ子、岩佐達郎
    • Organizer
      日本味と匂学会第48回大会
    • Place of Presentation
      清水文化会館マリナート(静岡県静岡市清水区)
    • Year and Date
      2014-10-02 – 2014-10-04
    • Related Report
      2014 Research-status Report
  • [Presentation] Expression and Structural Analysis of Two Kinds of Perireceptor Proteins(PRPs)2014

    • Author(s)
      Xing Li,Durige Wen,Masaru Hojo,Mamiko Ozaki,Tatsuo Iwasa
    • Organizer
      第52回日本生物物理学会
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市白石区)
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Research-status Report
  • [Presentation] 両生類の匂い分子結合タンパク質の匂い分子結合特性2014

    • Author(s)
      澤田 研,杉浦 康裕,鈴木 里奈,杉本 弘文,鳥井 綾乃,福田 永,岩佐 達郎
    • Organizer
      第66回日本生物工学会大会
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市白石区)
    • Year and Date
      2014-09-09 – 2014-09-11
    • Related Report
      2014 Research-status Report
  • [Presentation] Structural and Functional Analysis of the Role of Cysteine Residue in Cp-Lip2,Lipocalin-type Protein Found in the Olfactory Epithelium of Cynops Pyrrhogaster2013

    • Author(s)
      Xing Li,Junya Otsuka,Tatsuo Iwasa
    • Organizer
      日本生物工学会
    • Place of Presentation
      広島市・広島国際会議場
    • Related Report
      2013 Research-status Report
  • [Presentation] イモリ嗅上皮に発現する「匂い分子結合タンパク質」のシステイン残基の働き2013

    • Author(s)
      李興、大塚淳哉、澤田研、福田永、夛田芳宏、岩佐達郎
    • Organizer
      日本味と匂学会
    • Place of Presentation
      仙台市・仙台市民会館
    • Related Report
      2013 Research-status Report
  • [Presentation] Cp-Lip1タンパク質の有無による嗅神経細胞の匂い応答の違い2013

    • Author(s)
      杉本弘文、杉浦康裕、福田永、岩佐達郎、澤田研
    • Organizer
      日本味と匂学会
    • Place of Presentation
      仙台市・仙台市民会館
    • Related Report
      2013 Research-status Report
  • [Presentation] Highly Sensitive Analysis of Water-insoluble Nanoparticles and Soluble Protein in Liquid by Resonant Surface Acoustic Wave Modulation Measurement2013

    • Author(s)
      K. Ogawa, T.Abe, Y. Seino, T. Torigoe, Y. Tada, K. Uesugi, H. Fukuda, K. Sawada, T. Iwasa,
    • Organizer
      26th International Microprocess and Nanotechnology Conference
    • Place of Presentation
      Sapporo, Royton Sapporo
    • Related Report
      2013 Research-status Report
  • [Presentation] Study on the perireceptor protein (PRP) as the Sensor Element of a bioinspired erectricnose

    • Author(s)
      Xing Li, Wendurige, Tatsuo Iwasa
    • Organizer
      Joint Seminar on Environmental Science and Disaster Mitigation Research 2013 (JSED2013)
    • Place of Presentation
      Muroran, Muroran Institute of Technology
    • Related Report
      2013 Research-status Report
  • [Book] 室蘭工大 未来をひらく技術と研究2014

    • Author(s)
      岩佐達郎、澤田研 他
    • Total Pages
      230
    • Publisher
      北海道新聞社
    • Related Report
      2014 Research-status Report
  • [Remarks] 室蘭工業大学 研究者データベース 岩佐達郎

    • URL

      http://rd-soran.muroran-it.ac.jp/profile/ja.bi-P2c-xF-qtUJ6y55V67Q==.html

    • Related Report
      2013 Research-status Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

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