Study on the Bio-inspired electric nose and odor-coding theory
| Project/Area Number |
25440164
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Animal physiology/Animal behavior
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| Research Institution | Muroran Institute of Technology |
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Principal Investigator |
IWASA Tatsuo 室蘭工業大学, 工学(系)研究科(研究院), 教授 (00133926)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 匂い分子結合タンパク質 / 化学感覚タンパク質 / バイオ化学センサー / 生体機能指向型エレクトリックノーズ / レイリー型表面弾性波センサー / ＦＥＴセンサー / 遺伝子改変タンパク質発現 / タンパク質匂いセンサー素子 / 生体機能志向型エレクトリックノーズ / レイリー型表面弾性はセンサー / 匂い分別 / レイリー波 / 表面弾性波 / SAWデバイス / 電子鼻 / リポカリン / 部位特異的変異導入 / Chemosensory Protein |
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| Outline of Final Research Achievements |
This research project aims to make a prototype of a bio-inspired electric nose, which can detect different types of odorant molecules and distinguish them. In order to use the sensing-element of the electric nose, we plan to use odorant binding proteins of Japanese common newt, Cp-Lip1 and -Lip2 which we found and chemosensory proteins (CSPs) found in the sensillum of carpenter ant, Camponotus japonicus. The expression and purification system of the proteins from E. coli expression systems were established.The purified proteins retained their native secondary structure and binding properties. The amino acid replacement of Cp-Lip1 changed its odorant binding properties, which enable to obtain odorant-sensor elements of the different odorant-binding capacity. These sensor elements were fixed and used on a prototype of a surface acoustic wave (SAW) sensor and a field effect transistor (FET) sensor.
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Report
(4 results)
Research Products
(33 results)
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[Journal Article] Enantioselective diels-alder reaction of 1,2-dihydropyridines with aldehydes using beta-amino alcohol organocatalyst2014
Author(s)
Kohari Y, Okuyama Y, Kwon E, Furuyama T, Kobayashi N, Otuki T, Kumagai J, Seki C, Uwai K, Dai G, Iwasa T, Nakano H
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Journal Title
J Org Chem
Volume: 79
Issue: 20
Pages: 9500-9511
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Highly Sensitive Analysis of Water-insoluble Nanoparticles and Soluble Protein in Liquid by Resonant Surface Acoustic Wave Modulation Measurement2013
Author(s)
K. Ogawa, T.Abe, Y. Seino, T. Torigoe, Y. Tada, K. Uesugi, H. Fukuda, K. Sawada, T. Iwasa,
Organizer
26th International Microprocess and Nanotechnology Conference
Place of Presentation
Sapporo, Royton Sapporo
Related Report
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