Attempt of identification and characterization of novel bioactive peptides using the new extraction method
| Project/Area Number |
25440171
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Animal physiology/Animal behavior
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| Research Institution | Hiroshima University |
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Principal Investigator |
Iwakoshi Eiko 広島大学, 総合科学研究科, 研究員 (50311296)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 生理活性ペプチド / 鳥類 |
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| Outline of Final Research Achievements |
For the extraction of novel bioactive peptides, ordinary and routine methods using water-extraction combined with acid have been established and employed so far on animal tissues. In the present study, I sought novel bioactive substances in avian and mammalian tissues and tested several organic solvents for the efficient extraction. It was revealed that some bioactive peptides with hydrophobic properties which have been known in the previous studies were identified using dimethyl sulfoxide (DMSO), although I could not find a novel bioactive substance. I found that a novel extraction method using DMSO is suitable for the identification of highly hydrophobic substances.
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Report
(4 results)
Research Products
(13 results)
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[Journal Article] Identification of a cDNA encoding a novel small secretory protein, neurosecretory protein GL, in the chicken hypothalamic infundibulum.2014
Author(s)
Ukena K, Iwakoshi-Ukena E, Taniuchi S, Bessho Y, Maejima S, Masuda K, Shikano K, Kondo K, Furumitsu M, Tachibana T.
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Journal Title
Biochem. Biophys. Res. Commun.
Volume: 446
Issue: 1
Pages: 298-303
DOI
Related Report
Peer Reviewed / Open Access
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