Prostagladin protects neurons in hibernation

Research Project

Project/Area Number	25440174
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Animal physiology/Animal behavior
Research Institution	Kanagawa Dental College
Principal Investigator	Yamamoto Toshiharu 神奈川歯科大学, 歯学研究科(研究院), 准教授 (50111901)
Co-Investigator(Renkei-kenkyūsha)	SUZUKI Hirofumi 福岡教育大学, 教育学部, 教授 (20304694)
Project Period (FY)	2013-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000) Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000) Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000) Fiscal Year 2013: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Keywords	冬眠 / 視床下部 / プロスタグランジン / ｐERK / 脳 / 神経細胞
Outline of Final Research Achievements	Low temperature increased numbers of pERK (one of markers to detect reactive neurons to stress) immunoreactive neurons in the mouse hypothalamic paraventricular nucleus. This result suggests that the hypothalamus is one of brain areas where cope with low temperature stress. These hypothalamic neurons also contained E2 (one of prostaglandin receptors) immunoreactive structures that suggests that prostaglandin affects the hypothalamic paraventricular neurons. Getting together, low temperature stress may be sensed in the hypothalamus where prostaglandin probably functions as a neurotransmitter and/or neuromodulator affecting the hypothalamus.