Sex-determining mechanism in medaka-related species lacking Dmy
| Project/Area Number |
25440178
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Genetics/Chromosome dynamics
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| Research Institution | Niigata University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 発生遺伝 / 性決定 / 性染色体 / 性決定遺伝子 / 進化 / メダカ / 突然変異 / 遺伝子 / Gsdf / Dmrt1 / ハイナンメダカ / 性決定カスケード / Dmy |
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| Outline of Final Research Achievements |
We investigated the sex determination system and sex chromosomes in six celebensis group species. Our sex-linkage analysis demonstrated that all species had an XX-XY sex determination system, and that the Oryzias marmoratus and O. profundicola sex chromosomes were homologous to O. latipes linkage group (LG)10, while those of the other four species, O. celebensis, O. matanensis, etc., were homologous to O. lat. LG 24. The phylogenetic relationship suggested a turnover of the sex chromosomes from O. lat. LG 24 to LG 10 within this group. Sex-linkage maps suggested that the LG 24 acquired the SD function in a common ancestor of the celebensis group, and that the LG 10 SD function appeared in a common ancestor of O. mar. and O. pro. after the divergence of O. matanensis. Fine mapping and association analysis in the former two species revealed that Sox3 on the Y chromosome is a prime candidate for the SD gene, and that the Y-specific 430-bp insertion might be involved in its SD function.
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Report
(4 results)
Research Products
(10 results)
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[Journal Article] High levels of plasma cortisol and impaired hypoosmoregulation in a mutant medaka deficient in P450c17I.2016
Author(s)
Takahashi, H., Sato, T., Ikeuchi, T., Saito, K., Sakaizumi, M., Sakamoto T.
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Journal Title
Mol. Cell. Endocrinol.
Volume: in press
Related Report
Peer Reviewed
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[Journal Article] Co-option of Sox3 as the male-determining factor on the Y chromosome in the fish Oryzias dancena2014
Author(s)
Takehana, Y., Matsuda, M., Myosho, T., Suster, M.L., Kawakami, K., Shin-I, T., Kohara, Y., Kuroki, Y., Toyoda, A., Fujiyama, A., Hamaguchi, S., Sakaizumi, M., and Naruse, K.
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Journal Title
Nature Communications
Volume: 5
Issue: 1
Pages: 4157-4157
DOI
Related Report
Peer Reviewed / Open Access
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