Research Project
Grant-in-Aid for Scientific Research (C)
We investigated the sex determination system and sex chromosomes in six celebensis group species. Our sex-linkage analysis demonstrated that all species had an XX-XY sex determination system, and that the Oryzias marmoratus and O. profundicola sex chromosomes were homologous to O. latipes linkage group (LG)10, while those of the other four species, O. celebensis, O. matanensis, etc., were homologous to O. lat. LG 24. The phylogenetic relationship suggested a turnover of the sex chromosomes from O. lat. LG 24 to LG 10 within this group. Sex-linkage maps suggested that the LG 24 acquired the SD function in a common ancestor of the celebensis group, and that the LG 10 SD function appeared in a common ancestor of O. mar. and O. pro. after the divergence of O. matanensis. Fine mapping and association analysis in the former two species revealed that Sox3 on the Y chromosome is a prime candidate for the SD gene, and that the Y-specific 430-bp insertion might be involved in its SD function.
All 2016 2015 2014 2013
All Journal Article (5 results) (of which Peer Reviewed: 5 results, Acknowledgement Compliant: 1 results, Open Access: 1 results) Presentation (5 results)
Gen. Comp. Endocrinol.
Volume: in press Pages: 80-88
10.1016/j.ygcen.2015.10.004
Mol. Cell. Endocrinol.
Volume: in press
G3
Volume: 5 Pages: 2685-2691
Nature Communications
Volume: 5 Issue: 1 Pages: 4157-4157
10.1038/ncomms5157
Cytogenet. Genome Res.
Volume: 141 Pages: 212-226
