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DNA amplification in neuron

Research Project

Project/Area Number 25440181
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Genetics/Chromosome dynamics
Research InstitutionFukuoka Women's University

Principal Investigator

Ryota Matsuo  福岡女子大学, 文理学部, 准教授 (40334338)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
KeywordsDNA増幅 / 倍数化 / ニューロン / 腹足類 / ゲノムDNA増幅 / 遺伝子発現 / 転写後調節 / 神経投射 / 軟体動物腹足類
Outline of Final Research Achievements

The brain of gastropd mollusks contain many giant neurons whose genomic DNAs are repeatedly amplyfied (i.e. polyploid). The polyploidization is adaptive strategy of the animals, and is thought to occur in order to meet the increasing damand for macromolecules in the neurons to innervate growing peripheral organs during body growth. In the present research, we investigated following two issues: 1) How neurons in the brain sense the need to amplify their genomic DNA? 2) Is the amount of every mRNA increases concomitantly as a result of DNA polyploidization? We found that the neurons in the brain sense the need to amplify their own genome through innervation to the periferal organs. We also identified a pair of genes whose expression levels change in the opposite direction in the same polulation of neurons during body growth, suggesting a differential regulation of gene expression levels in a polyploidized neuron.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (26 results)

All 2016 2015 2014 2013 Other

All Journal Article (7 results) (of which Peer Reviewed: 7 results,  Acknowledgement Compliant: 4 results) Presentation (10 results) (of which Int'l Joint Research: 1 results,  Invited: 2 results) Book (4 results) Remarks (5 results)

  • [Journal Article] Olfactory memory storage and/or retrieval requires the presence of the exact tentacle used during memory acquisition in the terrestrial slug Limax.2016

    • Author(s)
      Koga Y, Matsuo Y, Matsuo R
    • Journal Title

      Zool Sci

      Volume: 33 Issue: 1 Pages: 78-82

    • DOI

      10.2108/zs150128

    • NAID

      40020738756

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Distribution of histaminergic neurons and their modulatory effects on oscillatory activity in the olfactory center of the terrestrial slug Limax2016

    • Author(s)
      Matsuo R, Fukata R, Kumagai M, Kobayashi A, Kobayashi S, Matsuo Y
    • Journal Title

      Journal of Comparative Neurology

      Volume: 524 Issue: 1 Pages: 119-135

    • DOI

      10.1002/cne.23829

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Octopaminergic system in the central nervous system of the terrestrial slug Limax2016

    • Author(s)
      Matsuo R, Tanaka M, Fukata R, Kobayashi S, Aonuma H, Matsuo Y
    • Journal Title

      J Comp Neurol

      Volume: in press Issue: 18 Pages: 3849-3864

    • DOI

      10.1002/cne.24039

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Photo-tropotaxis based on projection through the cerebral commissure in the terrestrial slug Limax.2014

    • Author(s)
      Matsuo Y, Uozumi N, Matsuo R.
    • Journal Title

      J Comp Physiol A

      Volume: 200 Issue: 12 Pages: 1023-1032

    • DOI

      10.1007/s00359-014-0954-7

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] The cholinergic system in the olfactory center of the terrestrial slug Limax.2014

    • Author(s)
      Matsuo R, Kobayashi S, Wakiya K, Yamagishi M, Fukuoka M, Ito E.
    • Journal Title

      J Comp Neurol

      Volume: in press Issue: 13 Pages: 2951-2966

    • DOI

      10.1002/cne.23559

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Involvement of nistric oxide in memory formation in microbrains.2013

    • Author(s)
      Ito E, Matsuo R, and Okada R
    • Journal Title

      Neuroscience Letters

      Volume: 541 Pages: 1-3

    • DOI

      10.1016/j.neulet.2013.02.021

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Target innervation is necessary for neuronal polyploidization in the terrestrial slug Limax2013

    • Author(s)
      Matsuo R, Yamagishi M, Wakiya K, Tanaka Y, and Ito E
    • Journal Title

      Developmental Neurobiology

      Volume: 73 Issue: 8 Pages: 609-620

    • DOI

      10.1002/dneu.22087

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Octopaminergic system in the brain of the terrestrial slug Limax.2015

    • Author(s)
      Matsuo R, Tanaka M, Fukata R, Kobayashi S, Aonuma H, and Matsuo Y
    • Organizer
      第40回日本比較内分泌学会・第37回日本比較生理生化学会合同大会
    • Place of Presentation
      JMSアステールプラザ(広島市)
    • Year and Date
      2015-12-12
    • Related Report
      2015 Annual Research Report
  • [Presentation] 非眼性光感知システムによる負の光走性行動2015

    • Author(s)
      松尾亮太
    • Organizer
      第86回日本動物学会大会
    • Place of Presentation
      新潟コンベンションセンター(新潟市)
    • Year and Date
      2015-09-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] ナメクジの脳におけるDNA増幅2015

    • Author(s)
      松尾亮太
    • Organizer
      大阪市立大学理学系研究科生物学科セミナー講演
    • Place of Presentation
      大阪市立大学理学部(大阪市)
    • Year and Date
      2015-09-07
    • Related Report
      2015 Annual Research Report
  • [Presentation] Ocular and non-ocular photosensig in the terrestrial slug Limax.2015

    • Author(s)
      Matsuo R, Nagata A, and Matsuo Y
    • Organizer
      13th International Society for Invertebrate Neuroscience
    • Place of Presentation
      Balaton Limnological Institute, Tihany, Hungary
    • Year and Date
      2015-08-28
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ニューロンにおけるDNA倍数化2015

    • Author(s)
      松尾亮太
    • Organizer
      山田科学振興財団研究交流会
    • Place of Presentation
      東京コンファレンスセンター有明(東京)
    • Year and Date
      2015-05-30
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Photo-tropotaxis based on projection through the cerebral commissure in the terrestrial slug Limax.2014

    • Author(s)
      Matsuo R
    • Organizer
      International Workshop
    • Place of Presentation
      Hawaii Tokai International College(ハワイ州ホノルル)
    • Year and Date
      2014-10-02
    • Related Report
      2014 Research-status Report
  • [Presentation] ナメクジ大脳神経節の交連部を介した光情報の左右比較2014

    • Author(s)
      松尾亮太、魚住奈々、松尾優子
    • Organizer
      第4回九州地区動物学談話会
    • Place of Presentation
      島原共同研修センター(長崎県島原市)
    • Year and Date
      2014-08-22
    • Related Report
      2014 Research-status Report
  • [Presentation] Negative phototropotaxis using bilateral eyes in the terrestrial slug Limax.2014

    • Author(s)
      Matsuo Y, Uozumi N, Matsuo R
    • Organizer
      ICN2014/第36回日本比較生理生化学会年会合同大会
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2014-07-31
    • Related Report
      2014 Research-status Report
  • [Presentation] ナメクジの嗅覚中枢におけるアセチルコリン作動性神経の分布と機能2013

    • Author(s)
      松尾亮太
    • Organizer
      日本比較生理生化学会第35回大会
    • Place of Presentation
      姫路
    • Related Report
      2013 Research-status Report
  • [Presentation] ナメクジの脳におけるニューロンのゲノムDNA増幅2013

    • Author(s)
      松尾亮太
    • Organizer
      日本動物学会第84回大会
    • Place of Presentation
      岡山
    • Related Report
      2013 Research-status Report
    • Invited
  • [Book] Brain Evolution by Design2016

    • Author(s)
      Matsuo R et al.
    • Publisher
      Springer
    • Related Report
      2015 Annual Research Report
  • [Book] Memory Consolidation2015

    • Author(s)
      Matsuo R et al.
    • Total Pages
      327
    • Publisher
      Nova Publishers
    • Related Report
      2015 Annual Research Report
  • [Book] 研究者が教える動物実験 第3巻2015

    • Author(s)
      松尾亮太、他38名
    • Total Pages
      222
    • Publisher
      共立出
    • Related Report
      2015 Annual Research Report
  • [Book] ブレインサイエンスレビュー2014

    • Author(s)
      松尾亮太、他
    • Total Pages
      290
    • Publisher
      クバプロ
    • Related Report
      2013 Research-status Report
  • [Remarks] 福岡女子大学 地域連携センター 研究者データベース

    • URL

      http://www.fwu.ac.jp/teachersdatabase/detail/?masterid=61&gakkaid=202&gakubuid=20

    • Related Report
      2015 Annual Research Report
  • [Remarks] Researchmap

    • URL

      http://researchmap.jp/matsuor/

    • Related Report
      2015 Annual Research Report
  • [Remarks] Research map

    • URL

      http://researchmap.jp/matsuor/

    • Related Report
      2014 Research-status Report
  • [Remarks] 福岡女子大学地域連携センター 研究者データベース

    • URL

      http://www.fwu.ac.jp/teachersdatabase/detail/?masterid=61&gakkaid=202&gakubuid=20

    • Related Report
      2014 Research-status Report
  • [Remarks] 福岡女子大学 研究者データベース

    • URL

      http://www.fwu.ac.jp/teachersdatabase/detail/?masterid=61&gakkaid=202&gakubuid=20

    • Related Report
      2013 Research-status Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

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