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Analysis and application of a new communication among oral bacteria using the conversion of autoinducer.

Research Project

Project/Area Number 25450103
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Applied microbiology
Research InstitutionYamaguchi University

Principal Investigator

Azakami Hiroyuki  山口大学, 農学部, 教授 (40263850)

Co-Investigator(Renkei-kenkyūsha) NOIRI Yuichiro  大阪大学, 歯学研究科, 准教授 (50218286)
Research Collaborator Fariha Jasin Mansur  
MORISHIGE Natsumi  
TAKAHARA Sari  
Mohammad Minnatul Karim  
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords歯周病原性細菌 / Eikenella corrodens / オートインデューサー / ポーリン / クオラムセンシング / quorum sensing / autoinducer / periodontal disease / 歯周病関連細菌
Outline of Final Research Achievements

Microorganisms communcate each other using various chemical compounds as language. Most pathogenic bacteria control their pathogenesis by these communication.Thus, if we can block their communication, we may apply it to treatment or prevention to many diseases. In this study, we found and cahracterized a new factor to block the bacterial communication. It is very interesting that this factor can block the wide range of communication among bacteria.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (24 results)

All 2016 2015 2014 2013

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Open Access: 2 results,  Acknowledgement Compliant: 2 results) Presentation (17 results) Book (1 results)

  • [Journal Article] Relationship between the risk for a shrimp allergy and freshness or cooking2015

    • Author(s)
      Masakatsu USUI, Akihito HARADA, Shinya YASUMOTO, Yoshimasa SUGIURA, Anri NISHIDAI, Maria IKARASHI, Honami TAKABA, Taiko MIYASAKI, Hiroyuki AZAKAMI, and Masakazu KONDO
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 未定 Issue: 10 Pages: 1698-1701

    • DOI

      10.1080/09168451.2015.1045830

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Unstable Mutant Lysozymes are Degraded through the Interaction with Calnexin Homologue Cne1p in Saccharomyces cerevisiae2014

    • Author(s)
      Azakami H. Uehara M. Matsuo R. Yamashita Y. Usui M. Kato A.
    • Journal Title

      Biosci. Biotechol. Biochem

      Volume: 78 Issue: 7 Pages: 1263-1269

    • DOI

      10.1080/09168451.2014.918486

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Effects of the tea catechin epigallocatechin gallate on Porphyromonas gingivalis biofilms2014

    • Author(s)
      Asahi Y. et al.
    • Journal Title

      Jouranl of Applied Microbiology

      Volume: 116 Issue: 5 Pages: 1164-1171

    • DOI

      10.1111/jam.12458

    • Related Report
      2014 Research-status Report 2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] LuxS Affects Biofilm Maturation and Detachment of the Periodontopathogenic Bacterium Eikenella corrodens2013

    • Author(s)
      MM. Karim, T. Hisamoto, T. Matsunaga, Y. Asahi, Y. Noiri, S. Ebisu, A. Kato, H. Azakami
    • Journal Title

      Journal of Bioscience and Bioengineering

      Volume: 116 Issue: 3 Pages: 313-318

    • DOI

      10.1016/j.jbiosc.2013.03.013

    • NAID

      110009657226

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] The Periodontopathogenic Bacterium <i>Eikenella corrodens</i> Produces an Autoinducer-2-Inactivating Enzyme2013

    • Author(s)
      MM. Karim, A. Nagao, FJ. Mansur, T. Matsunaga, Y. Akakabe, Y. Noiri, S. Ebisu, A. Kato, H. Azakami
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 77 Issue: 5 Pages: 1080-1085

    • DOI

      10.1271/bbb.130047

    • NAID

      10031177600

    • ISSN
      0916-8451, 1347-6947
    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Contribution of Structural Reversibility to the Heat Stability of the Tropomyosin Shrimp Allergen2013

    • Author(s)
      Masakatsu USUI, Akihito HARADA, Takayuki ISHIMARU, Emiri SAKUMICHI, Fumihiko SARATANI, Chiho SATO-MINAMI, Hiroyuki AZAKAMI, Taiko MIYASAKI, Ken'ichi HANAOKA
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 77 Issue: 5 Pages: 948-953

    • DOI

      10.1271/bbb.120887

    • NAID

      10031177579

    • ISSN
      0916-8451, 1347-6947
    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Autoinducer-inactivation mechanism in periodontopathogenic bacterium Eikenella corrodens2016

    • Author(s)
      Fariha Jasin Mansur、阿座上弘行
    • Organizer
      日本細菌学会
    • Place of Presentation
      大阪国際交流センター(大阪府大阪市)
    • Year and Date
      2016-03-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] 歯周病原性細菌Eikenella corrodensにおけるオートインデューサー不活化機構の解析2015

    • Author(s)
      Fariha Jasin Mansur、森重なつみ、飯田亮平、島谷雅文、阿座上弘行
    • Organizer
      日本生物工学会
    • Place of Presentation
      城山観光ホテル(鹿児島県鹿児島市)
    • Year and Date
      2015-10-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] 歯周病原性細菌Eikenella corrodensにおけるオートインデューサー不活化機構の解析2015

    • Author(s)
      阿座上弘行、Fariha Jasin Mansur、森重なつみ
    • Organizer
      日本微生物生態学会
    • Place of Presentation
      土浦亀城プラザ(茨城県土浦市)
    • Year and Date
      2015-10-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] 歯周病原性細菌Eikenella corrodensにおけるオートインデューサー不活化機構の解析2015

    • Author(s)
      Fariha Jasin Mansur、森重なつみ、飯田亮平、島谷雅文、阿座上弘行
    • Organizer
      日本農芸化学会中四国・西日本合同支部大会
    • Place of Presentation
      愛媛大学(愛媛県松山市)
    • Year and Date
      2015-09-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] Autoinducer-2 inactivation by outer membrane porin in periodontopathogenic bacterium Eikenella corrodens2015

    • Author(s)
      Fariha Jasin Mansur、森重なつみ、野杁由一郎、阿座上弘行
    • Organizer
      日本農芸化学会
    • Place of Presentation
      岡山大学 (岡山市)
    • Year and Date
      2015-03-29
    • Related Report
      2014 Research-status Report
  • [Presentation] 歯周病原性細菌Eikenella corrodensにおけるゲノム再編による溶血活性の発現2015

    • Author(s)
      高原沙里、下川床愛、野杁由一郎、阿座上弘行
    • Organizer
      日本農芸化学会
    • Place of Presentation
      岡山大学 (岡山市)
    • Year and Date
      2015-03-27
    • Related Report
      2014 Research-status Report
  • [Presentation] 歯周病原性細菌Eikenella corrodensの外膜ポーリンによるオートインデューサー2の不活化機構2014

    • Author(s)
      森重なつみ、Fariha Jasin Mansur、飯田亮平、野杁由一郎、阿座上弘行
    • Organizer
      日本生物工学会
    • Place of Presentation
      札幌コンベンションセンター (札幌市)
    • Year and Date
      2014-09-10
    • Related Report
      2014 Research-status Report
  • [Presentation] 歯周病原性細菌Eikenella corrodensのX-プロリルアミノペプチダーゼが溶血に関与する?2014

    • Author(s)
      高原沙里、下川床愛、野杁由一郎、阿座上弘行
    • Organizer
      日本生物工学会
    • Place of Presentation
      札幌コンベンションセンター (札幌市)
    • Year and Date
      2014-09-10
    • Related Report
      2014 Research-status Report
  • [Presentation] Purification and characterization of autoinducer-2 inactivating enzyme in periodontopathogenic bacterium Eikenella corrodens2014

    • Author(s)
      〇Fariha Manusr、Mohammad Karim、Yuichiro Noiri、Hiroyuki Azakami
    • Organizer
      IUMS2014
    • Place of Presentation
      モントリオール (カナダ)
    • Year and Date
      2014-07-30
    • Related Report
      2014 Research-status Report
  • [Presentation] 歯周病原性細菌Eikenella corrodensのポーリンがオートインデューサーの不活化に関与する2014

    • Author(s)
      阿座上弘行、Mansur Jasin、野杁由一郎、加藤昭夫
    • Organizer
      日本農芸化学会
    • Place of Presentation
      明治大学生田キャンパス(川崎市)
    • Related Report
      2013 Research-status Report
  • [Presentation] Involvement of porin in inactivation of autoinducer 2 in Eikenella corrodens2014

    • Author(s)
      Mansur Jasin、野杁由一郎、阿座上弘行
    • Organizer
      日本細菌学会
    • Place of Presentation
      タワーホール船堀(東京都江戸川区)
    • Related Report
      2013 Research-status Report
  • [Presentation] The periodontopathogenic bacterium Eikenella corrodens produces an autoinducer-2-inactivating enzyme2013

    • Author(s)
      Hiroyuki Azakami, Mansur Jasin
    • Organizer
      日本微生物生態学会
    • Place of Presentation
      鹿児島大学(鹿児島市)
    • Related Report
      2013 Research-status Report
  • [Presentation] 歯周病原性細菌の可溶性ポーリンがオートインデューサーを不活化する?2013

    • Author(s)
      阿座上弘行、Mansur Jasin、Karim Minnatul、野杁由一郎
    • Organizer
      日本生物工学会
    • Place of Presentation
      広島国際会議場(広島市)
    • Related Report
      2013 Research-status Report
  • [Presentation] Eikenella corrodens produces an autoinducer-2-inactivating enzyme2013

    • Author(s)
      Fariha Jasin Mansur, Mohammad Minnatul Karim, Yuichiro Noiri, Shigeyuki Ebisu, Hiroyuki Azakami
    • Organizer
      Nobel Conference on Biofilm formation, its clinical impact and potential treatment
    • Place of Presentation
      Stockholm, Sweden
    • Related Report
      2013 Research-status Report
  • [Presentation] LuxS affects biofilm maturation and detachment of the periodontopathogenic bacterium Eikenella corrodens2013

    • Author(s)
      Mohammad Minnatul Karim, Fariha Jasin Mansur, Tatsunori Hisamoto, Tetsuro Matsunaga, Yoko Asahi, Yuichiro Noiri, Shigeyuki Ebisu, Akio Kato, Hiroyuki Azakami
    • Organizer
      Nobel Conference on Biofilm formation, its clinical impact and potential treatment
    • Place of Presentation
      Stockholm, Sweden
    • Related Report
      2013 Research-status Report
  • [Presentation] The Periodontopathogenic Bacterium Eikenella corrodens Produces an Autoinducer-2-Inactivating Enzyme2013

    • Author(s)
      Hiroyuki Azakami, Karim Minnatul, Mansur Jasin, Yuichiro Noiri, Shigeyuki Ebisu
    • Organizer
      Gordon Conference (Bacterial Adhesion & Signal Transduction)
    • Place of Presentation
      Newport, USA
    • Related Report
      2013 Research-status Report
  • [Presentation] 歯周病関連細菌Eikenella corrodensのAI-2不活化酵素の精製と解析2013

    • Author(s)
      阿座上弘行、Karim Minnatul、Mansur Jasin、野杁由一郎、恵比須繁之
    • Organizer
      Bacterial Adherence & Biofilm学術集会
    • Place of Presentation
      東京ガーデンパレス(東京都文京区)
    • Related Report
      2013 Research-status Report
  • [Book] 「細胞間コミュニケーションと口腔細菌バイオフィルム」特集『バイオフィルム研究の最前線』2015

    • Author(s)
      阿座上弘行、恵比須繁之
    • Total Pages
      180
    • Publisher
      医薬ジャーナル社
    • Related Report
      2015 Annual Research Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

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