| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
The expression of cellulose-degrading enzyme genes are controlled by various regulators in filamentous fungi. We have identified that transcription factor, ClbR, interacts with its paralog, ClbR2, and which regulate the expression of the gene encoding transcription factor, ClrB (ManR). Expressed ClrB appears to induce the expression of cellulase and xylanase genes. We revealed that protein kinase and protein phosphatase control the cellulose responsive gene expression. Further analysis enabled to isolate another 2 cellulose-utilization deficient mutants.
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