Functional analysis of ClbR controlling cellulose responsibe inductin in filamentous fungi
| Project/Area Number |
25450110
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied microbiology
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| Research Institution | Osaka Prefecture University |
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Principal Investigator |
Tani Shuji 大阪府立大学, 生命環境科学研究科(系), 講師 (80405357)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | Aspergillus aculeatus / セルラーゼ遺伝子 / 発現制御 / セルラーゼ / 遺伝子発現制御 / ClbR / セルロース系バイオマス分解酵素遺伝子 / セルロース誘導 |
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| Outline of Final Research Achievements |
The expression of cellulose-degrading enzyme genes are controlled by various regulators in filamentous fungi. We have identified that transcription factor, ClbR, interacts with its paralog, ClbR2, and which regulate the expression of the gene encoding transcription factor, ClrB (ManR). Expressed ClrB appears to induce the expression of cellulase and xylanase genes. We revealed that protein kinase and protein phosphatase control the cellulose responsive gene expression. Further analysis enabled to isolate another 2 cellulose-utilization deficient mutants.
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Report
(4 results)
Research Products
(22 results)
