| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
Chitin is a polysaccharide that comprises a major constituent of fungal cell walls, the exoskeletons of insects, and the shells of crustaceans. N-acetylglucosamine (GlcNAc) and Glucosamine (GlcN), which is derived from the hydrolysis of chitin or chitosan,have a variety of biological functions and have therefore been used as a food additive and in medicines. Using the chitin catabolic pathway of hyperthemophilie,we have focused two thermostable enzymes, deacetylase (Dac) (EC 3.5.1.-) and β-N-acetylglucosaminidases (NagA) (EC 3.2.1.52). To understand the catalysis and adaptation to extreme high temperature of these enzymes, we have determined the structures of Dac and NagA.
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