| Project/Area Number |
25450144
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Bioorganic chemistry
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| Research Institution | Okayama University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
IZUMI Minoru 岡山大学, 大学院環境生命科学研究科, 准教授 (90379719)
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| Co-Investigator(Renkei-kenkyūsha) |
UCHIDA Takafumi 東北大学, 農学研究科, 教授 (80312239)
USUI Takeo 筑波大学, 生命環境科学研究科, 准教授 (60281648)
KAWATANI Makoto 理化学研究所, 基幹研究所, 研究員 (50391925)
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| Research Collaborator |
SHI Qinq-Wen 河北医科大学, 教授
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | structure elucidation / total synthesis / antibitics / marine products / polyketides / terpenoids / enacyloxins / sialidase / 全合成 / 抗生物質 / enacyloxin / maoecrystal V / taxane / 単離構造決定 / sanctlide A / thelepamide / sanctolide A / organocuprate / echinopine / JBIR-23 / cortistain |
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| Outline of Final Research Achievements |
Naturally occurring organic compounds of low molecular weight and the derivatives have been used as agrochemicals and/or medicines to date. We have achieved the isolation and structure elucidation of several novel terpenoids and polyketides from plants such as a yew, a manglobe, herbs etc. We have also succeeded in the total or partial synthesis of biologically active natural products such as enacyloxins and spirofungins (antibiotics), thelepamide and clionamine D (marine natural products), maoecrystal V and echinopine A (herbal products), pyriculariol (a plant pathogenic compound) etc. 2,3-Difluorosialic acid, synthesized with the aim to develop a new anti-influenza agent, inhibited the sialidase of Tamiflu-resistant strain.
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