Development of agrochemical and pharmaceutical lead compounds based on the search and total synthesis of natural compounds with a unique structure and biological activity

• Project/Area Number: 25450144
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Bioorganic chemistry
• Research Institution: Okayama University
• Principal Investigator: Kiyota Hiromasa 岡山大学, その他の研究科, 教授 (30234397)
• Co-Investigator(Kenkyū-buntansha): IZUMI Minoru 岡山大学, 大学院環境生命科学研究科, 准教授 (90379719)
• Co-Investigator(Renkei-kenkyūsha): UCHIDA Takafumi 東北大学, 農学研究科, 教授 (80312239) ; USUI Takeo 筑波大学, 生命環境科学研究科, 准教授 (60281648) ; KAWATANI Makoto 理化学研究所, 基幹研究所, 研究員 (50391925)
• Research Collaborator: SHI Qinq-Wen 河北医科大学, 教授
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: structure elucidation / total synthesis / antibitics / marine products / polyketides / terpenoids / enacyloxins / sialidase / 全合成 / 抗生物質 / enacyloxin / maoecrystal V / taxane / 単離構造決定 / sanctlide A / thelepamide / sanctolide A / organocuprate / echinopine / JBIR-23 / cortistain

Outline of Final Research Achievements

Naturally occurring organic compounds of low molecular weight and the derivatives have been used as agrochemicals and/or medicines to date. We have achieved the isolation and structure elucidation of several novel terpenoids and polyketides from plants such as a yew, a manglobe, herbs etc. We have also succeeded in the total or partial synthesis of biologically active natural products such as enacyloxins and spirofungins (antibiotics), thelepamide and clionamine D (marine natural products), maoecrystal V and echinopine A (herbal products), pyriculariol (a plant pathogenic compound) etc. 2,3-Difluorosialic acid, synthesized with the aim to develop a new anti-influenza agent, inhibited the sialidase of Tamiflu-resistant strain.

Research Products

• [Int'l Joint Research] 河北医科大学/安徽農業大学/中国科学アカデミー(中国)
• [Journal Article] 12T061A and 12T061C, two new julichrome family compounds, as radical scavengers from <i>Streptomyces</i> sp. (2016)
  • Author(s): Toshikazu Komoda, Naoko Saeki, Yoshitaka Koseki, Hiromasa Kiyota
  • Journal Title: The Journal of General and Applied Microbiology Volume: 62 Issue: 1 Pages: 1-6
  • DOI: 10.2323/jgam.62.1
  • NAID: 130005127281
  • ISSN: 0022-1260, 1349-8037
  • Peer Reviewed
• [Journal Article] Isolation of endosulfan sulfate-degrading Rhodococcus koreensis strain S1-1 from endosulfan contaminated soil and identification of a novel metabolite, endosulfan diol monosulfate (2016)
  • Author(s): Koji Ito, Fujimasa Kawashima, Kazuhiro Takagi, Ryota Kataoka, Masaaki Kotake, Hiromasa Kiyota, Kenichi Yamazaki, Futa Sakakibara, Sanae Okada
  • Journal Title: Biochem. Biophys. Res. Commun. Volume: in press Issue: 4 Pages: 1094-1099
  • DOI: 10.1016/j.bbrc.2016.04.021
  • Peer Reviewed
• [Journal Article] Synthetic Studies of Enacyloxins: a Series of Antibiotics Isolated from Frateuria sp. W-315: C1'-C8' and C9'-C15' Fragments (2015)
  • Author(s): Aki Saito, Wataru Igarashi, Hiroyuki Furukawa, Teiko Yamada, Shigefumi Kuwahara, Hiromasa Kiyota
  • Journal Title: Nat. Prod. Commun. Volume: 10 Pages: 645-648
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Kinetics of octachlorodipropyl ether photolysis in aqueous solution (2015)
  • Author(s): Yan-Hong Shi, Min Liao, Hiromasa Kiyota, Hai-Qun Cao, Ri-Mao Hua, Feng Tang, Yong-De Yue
  • Journal Title: Journal of Pesticide Science Volume: 40 Issue: 2 Pages: 49-54
  • DOI: 10.1584/jpestics.D14-061
  • NAID: 130005073198
  • ISSN: 1348-589X, 1349-0923
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] New Limonoids from the Seeds of Xylocarpus granatum (2015)
  • Author(s): Yi-Bing Wu, Dan Liu, Pei-Yu Liu, Xue-Mei Yang, Man Liao, Nan-Nan Lu, Francoise Sauriol, Yu-Cheng Gu, Qing-Wen Shi, Hiromasa Kiyota, Mei Dong
  • Journal Title: Helv. Chim. Acta Volume: 92 Issue: 5 Pages: 691-698
  • DOI: 10.1002/hlca.201400290
  • NAID: 120005666073
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Kinetics of Octachlorodipropyl Ether Photolysis in Aqueous Solution (2015)
  • Author(s): Yan-Hong Shi, Min Liao, Hiromasa Kiyota, Ri-Mao Hua, Xiang-Wei Wu, Jun Tang, Hai-Qun Cao
  • Journal Title: Furesen. Environ. Bull. Volume: 40 Pages: 49-54
  • NAID: 130005073198
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Two New Taxane-glycosides from the Needles of Taxus canadensis (2015)
  • Author(s): Nan Li, JIn Wang, Hui-Min Yan, Man-Li Zhang, Qing-Wen Shi, Francoise Sauriol, Hiromasa Kiyota, Mei Dong
  • Journal Title: Z. Naturforsch. Volume: 70b Issue: 11 Pages: 829-835
  • DOI: 10.1515/znb-2015-0074
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Synthesis of the Spiroacetal Fragments of Spifofungins A and B, Antibiotics Isolated from Streptomyces violaceusniger T&#252; 4113 (2015)
  • Author(s): Hiroyuki Sakauchi, Emi Higashi, Yuko Shimizu, Mikiko Kojima, Yuko Asamitsu, Shigefumi Kuwahara, Minoru Izumi, Hiromasa Kiyota
  • Journal Title: Heterocycl. Commun. Volume: 21 Issue: 6 Pages: 337-343
  • DOI: 10.1515/hc-2015-0193
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Synthetic Studies of Enacyloxins: a Series of Antibiotics Isolated from Frateuria sp. W-315: C1'-C8' and C9'-C15' Fragments (2015)
  • Author(s): Aki Saito, Wataru Igarashi, Hiroyuki Furukawa, Teiko Yamada, Shigefumi Kuwahara, Hiromasa Kiyota
  • Journal Title: Natural Product Communications Volume: 10 Pages: 645-648
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Structural Modification of Isoalantolactone and Biological Activity Against the Hepatoma Cell Line (2014)
  • Author(s): Rui-Xia Guo, Li-Geng Li, Man-Li Zhang, Françoise Sauriol, Qing-Wen Shi, Yu-Cheng Gu, Hiromasa Kiyota
  • Journal Title: Heterocyclic Communications Volume: 20 Issue: 2 Pages: 117-121
  • DOI: 10.1515/hc-2013-0220
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Novel Phosphorylation of Aldrin-trans-diol by Dieldrin-degrading Fungus Mucor racemosus strain DDF (2014)
  • Author(s): Ken-ichi Yamazaki, Kazuhiro Takagi, Ryota Kataoka, Masaaki Kotake, Teiko Yamada, Hiromasa Kiyota
  • Journal Title: International Biodeterioration and Biodegradation Volume: 92 Pages: 36-40
  • DOI: 10.1016/j.ibiod.2014.04.005
  • Peer Reviewed
• [Journal Article] Synthesis of o-Formyl-m-hydroxycinnamic Acid, the Most Oxidized Salicylaldehyde-type Phytotoxin Isolated from Rice Blast Fungus, Magnaporthe grisea, from 5-(2,2-Dimethyl-4H-1,3-benzdioxin)methanol (2014)
  • Author(s): Akihito Saito, Konosuke Hiramatsu, Hai-Qun Cao, Yuta Nagashima, Koji Tanaka, Ayaka Sasaki, Teiko Yamada, Shigefumi Kuwahara, Manabu Nukina, Hiromasa Kiyota
  • Journal Title: Heterocyclic Communications Volume: 20 Issue: 3 Pages: 185-188
  • DOI: 10.1515/hc-2014-0053
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Facile Synthesis of the Cyclohexane Fragment of Enacyloxins, a Series of Antibiotics Isolated from Frateruria sp. W-315 (2014)
  • Author(s): Aki Saito, Wataru Igarashi, Hiroyuki Furukawa, Teiko Yamada, Shigefumi Kuwahara, Hiromasa Kiyota
  • Journal Title: Bioscience, Biotechnology, and Biochemistry Volume: 78 Issue: 5 Pages: 766-769
  • DOI: 10.1080/09168451.2014.905192
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] A New Eudesmane Sesquiterpene from Dichrocephala integrifolia (2014)
  • Author(s): Fang Qin, Yi-Bing Wu, Rui-Xia Guo, Mei Dong, Françoise Sauriol, Qing-Wen Shi, Yu-Cheng Gu, Hiromasa Kiyota
  • Journal Title: Natural Product Communications Volume: 9 Pages: 149-150
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] 環状ジエン殺虫剤分解菌の探索と汚染現場への適用 (2014)
  • Author(s): 高木和広、清田洋正、片岡良太、山崎健一
  • Journal Title: 生産・流通・加工工程における体系的な危害要因の特製解明とリスク低減技術の開発 研究成果 Volume: - Pages: 185-191
• [Journal Article] Xylomexicanin E-H, New Limonoids from Xylocarpus granatum (2014)
  • Author(s): Yi-Bing Wu, Xia Qing, Chang-Hong Huo, Hui-Min Yan, Qing-Wen Shi, Françoise Sauriol, Yu-Cheng Gu, Hiromasa Kiyota
  • Journal Title: Tetrahedron Volume: 70 Issue: 30 Pages: 4557-4562
  • DOI: 10.1016/j.tet.2014.04.062
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] 難分解性土壌残留農薬ディルドリンの分解菌の探索と代謝経路の同定 (2014)
  • Author(s): 清田洋正
  • Journal Title: 岡山大学環境報告書 Volume: - Pages: 16-16
• [Journal Article] 12T061C, a New Julichrome Family Radical Scavenger from Streptomyces species (2014)
  • Author(s): Toshikazu Komoda, Naoko, Saeki, Yoshitaka Koseki, Hiromasa Kiyota
  • Journal Title: Heterocyclic Communications Volume: 20 Issue: 5 Pages: 271-274
  • DOI: 10.1515/hc-2014-0126
  • Peer Reviewed
• [Journal Article] Chemical Constituents of Plants from the Genus Neolitsea (2014)
  • Author(s): Xia Qing, Ting Zhao, Rui-Xia Guo, Yi-Bing Wu, Qing-Wen Sh, Yu-Cheng Gu, Hiromasa Kiyota
  • Journal Title: Heterocyclic Communications Volume: 20 Issue: 2 Pages: 61-75
  • DOI: 10.1515/hc-2013-0239
  • Peer Reviewed
• [Journal Article] Cytotoxic Flavonoids from the Flowers of Achillea millefolium (2013)
  • Author(s): Chang-Hong Huo, Yong Li, Mei Dong, Man-Li Zhang, Yu-Fang Wang, Qing Zhang, Fang Qin, Qing-Wen Shi, Hiromasa Kiyota
  • Journal Title: Chemistry of Natural Compounds Volume: 48 Pages: 958-962
  • Peer Reviewed
• [Journal Article] A New Alkaloidal Taxane Composed of Two N-Formyl Rotamers from the Rooted Cuttings of Taxus canadensis (2013)
  • Author(s): Yong Li Yu-Fang Wang, Man-Li Zhang, Mei Dong, Chang-Hong Huo, Françoise Sauriol, Qing-Wen Shi, Yu-Cheng Gu, Bin Cong, Hiromasa Kiyota
  • Journal Title: Chemistry of Natural Compounds Volume: 48 Pages: 1035-1038
  • Peer Reviewed
• [Journal Article] Influenza Neuraminidase Operates vis a Nucleophilic Mechanism and can Be Tageted by Covalent Inhibitors (2013)
  • Author(s): C. J. Vavricka
  • Journal Title: Nat. Commun. Volume: 4 Issue: 1 Pages: 1491-1491
  • DOI: 10.1038/ncomms2487
  • Peer Reviewed
• [Journal Article] Torreyanoxane, a New 3,4-Seco-glutinane Triterpenoid Isolated from the Pulp of Torreya nucifera (2013)
  • Author(s): C.-M. Cao
  • Journal Title: Helv. Chim. Acta Volume: 96 Issue: 3 Pages: 375-378
  • DOI: 10.1002/hlca.201200174
  • Peer Reviewed
• [Journal Article] Xylomexicanins C and D, New Mexicanolide-Type Limonoids from <i>Xylocarpus granatum</i> (2013)
  • Author(s): Z.-Y. Ni
  • Journal Title: Bioscience, Biotechnology, and Biochemistry Volume: 77 Issue: 4 Pages: 736-740
  • DOI: 10.1271/bbb.120815
  • NAID: 10031170711
  • ISSN: 0916-8451, 1347-6947
  • Peer Reviewed
• [Journal Article] Functional and structural analysis of influenza virus neuraminidase N3 offers further insight into the mechanisms of oseltamivir resistance (2013)
  • Author(s): Qing Li, Jianxun Qi, Yan Wu, Hiromasa Kiyota, Kosuke Tanaka, Yoshitomo Suhara, Hiroshi Ohrui, Yasuo Suzuki, Christpher J. Vavricka, George F. Gao
  • Journal Title: Journal of Virology Volume: 87 (18) Issue: 18 Pages: 10016-10024
  • DOI: 10.1128/jvi.01129-13
  • Peer Reviewed
• [Journal Article] A New Germacrane Sesquiterpenolide Isolated from Artemisia frigida (2013)
  • Author(s): Man-Li Zhang, Zhi-Yu Ni, Cun-Fang Li, Yu-Fang Wang, Mei Dong, Françoise Sauriol, Chang-Hong Huo, Qing-Wen Shi, Teiko Yamada, Hiromasa Kiyota, Yu-Cheng Gu, Bin Cong
  • Journal Title: Chemistry of Natural Compounds Volume: 49 Pages: 626-628
  • Peer Reviewed
• [Journal Article] 11-Hydroxyisocom-2-en-5-one,a A New Sesquiterpenoid from Echinops spinosissimus (2013)
  • Author(s): Zhi-Yu Ni, Yuta Nagashima, Man-Li Zhang, Yu-Fang Wang, Mei Dong, Françoise Sauriol, Chang-Hong Huo, Qing-Wen Shi, Yu-Cheng Gu, Hiromasa Kiyota
  • Journal Title: Chemistry of Natural Compounds Volume: 49 Pages: 632-634
  • Peer Reviewed
• [Journal Article] A New Taxane with a 4beta,20-Epoxy Ring from the Rooted Cuttings of Taxus canadensis (2013)
  • Author(s): Geng-Dong Yao, Hong-Feng Zhang, Yun Huang, Françoise Sauriol, Qing-Wen Shi, Hiromasa Kiyota, Yu-Cheng Gu
  • Journal Title: Chemistry of Natural Compounds Volume: 49 Pages: 861-863
  • Peer Reviewed
• [Journal Article] Arteminal, a New Eudesmane Sesquiterpenolide Isolated from Artemisia frigida (2013)
  • Author(s): Cun-Fang Li, Man-Li Zhang, Yu-Fang Wang, Mei Dong, Françoise Sauriol, Chang-Hong Huo, Qing-Wen Shi, Teiko Yamada, Hiromasa Kiyota, Yu-Cheng Gu, Bin Cong
  • Journal Title: Chemistry of Natural Compounds Volume: 49 Pages: 872-874
  • Peer Reviewed
• [Presentation] 抗生物質スピロファンジンＡ、Ｂの合成研究 (2016)
  • Author(s): 阪内啓之、東栄美、清水由布子、小嶋美紀子、朝光優子、桑原重文、泉実、清田洋正
  • Organizer: 日本農薬学会第41回大会
  • Place of Presentation: 松江
  • Year and Date: 2016-03-19
• [Presentation] 海洋環形動物から単離されたThelepamideの合成研究 ～oxazolinone環モデルの合成～ (2016)
  • Author(s): 井田浩介、泉実、清田洋正
  • Organizer: 日本農芸化学会中四国支部第43回講演会
  • Place of Presentation: 岡山
  • Year and Date: 2016-01-23
• [Presentation] 天然有機化合物の合成：構造の誤りと訂正 ～自らを省みて (2015)
  • Author(s): 清田洋正
  • Organizer: 関学フォーラム「化学と倫理」
  • Place of Presentation: 大阪
  • Year and Date: 2015-11-21
  • Invited
• [Presentation] 抗腫瘍物質maoecrystal Vの合成研究 (2015)
  • Author(s): 清田洋正、小竹正晃、佐藤勇気、佐々木郁香、浅尾洋樹、島崎泰治、桑原重文
  • Organizer: 2015年日本化学会中四国支部大会（岡山）
  • Place of Presentation: 岡山
  • Year and Date: 2015-11-15
• [Presentation] 植物鉄輸送体ニコチアナミンの合成および蛍光プローブ作製 (2015)
  • Author(s): 高石茂宏、平田智大、清田洋正、泉実
  • Organizer: 2015年日本化学会中四国支部大会（岡山）
  • Place of Presentation: 岡山
  • Year and Date: 2015-11-15
• [Presentation] 酵素法と化学合成法を用いたガラクトフラノシド誘導体の合成 (2015)
  • Author(s): 太田涼、篠塚早紀、竹川薫、岡拓二、清田洋正、泉実
  • Organizer: 2015年日本化学会中四国支部大会（岡山）
  • Place of Presentation: 岡山
  • Year and Date: 2015-11-15
• [Presentation] 抗マツノザイセンチュウ薬剤の開発及び新規アッセイ法の探索 (2015)
  • Author(s): 平田智大、中村健太郎、清田洋正、中島修平、泉実
  • Organizer: 第30回農薬デザイン研究会
  • Place of Presentation: 京都
  • Year and Date: 2015-11-12
• [Presentation] 抗生物質エナシロキシン類の合成研究 (2015)
  • Author(s): 清田洋正、五十嵐渉、齋藤亜紀、古川博之、星川浩輝、桑原重文
  • Organizer: 第57回天然有機化合物討論会
  • Place of Presentation: 横浜
  • Year and Date: 2015-09-10
• [Presentation] Discovery and improvement of covalent influenza neuraminidase inhibitors (2015)
  • Author(s): Christopher J. Vavricka, Chiaki Muto, Minoru Izumi, Hiromasa Kiyota
  • Organizer: 250th ACS National Meeting & Expositio
  • Place of Presentation: Boston 米国
  • Year and Date: 2015-08-17
  • Int'l Joint Research
• [Presentation] 脂肪酸合成経路阻害物質platensimycinの合成研究 (2015)
  • Author(s): 清田洋正、佐藤恵里子、桑原重文
  • Organizer: 日本農芸化学会中四国支部第42回講演会（鳥取）
  • Place of Presentation: 鳥取
  • Year and Date: 2015-06-13
• [Presentation] インフルエンザ・シアリダーゼ阻害剤の開発：二フッ化シアル酸 (2015)
  • Author(s): 清田洋正、Christopher J. Vavricka、田中皓祐、桑原重文、鈴木康夫、大類洋、George F. Gao
  • Organizer: 日本農芸化学会2015年度大会シンポジウム
  • Place of Presentation: 岡山
  • Year and Date: 2015-03-29
  • Invited
• [Presentation] 抗生物質Enacyloxin 類の全合成研究 (2015)
  • Author(s): 清田洋正、五十嵐渉、齋藤亜紀、古川博之、星川浩輝、山田てい子、桑原重文
  • Organizer: 日本農芸化学会2015年度大会（岡山）
  • Place of Presentation: 岡山
  • Year and Date: 2015-03-28
• [Presentation] Total Synthesis of Nicotianamine and Non-natural Analogues (2015)
  • Author(s): Tomohiro Hirata, Yuki Kido, Hiromasa Kiyota, Minoru Izumi
  • Organizer: Okayama University Campus Asia Program in Korea
  • Place of Presentation: Korea
  • Year and Date: 2015-02-12
• [Presentation] インフルエンザ・シアリダーゼ阻害剤の開発：二フッ化シアル酸 (2015)
  • Author(s): 清田洋正、Christopher J. Vavricka、田中皓祐、桑原重文、鈴木康夫、大類洋、George F. Gao
  • Organizer: 日本農芸化学会2014年度中四国支部大会
  • Place of Presentation: 下関
  • Year and Date: 2015-01-24
• [Presentation] 二フッ化シアル酸：インフルエンザ・シアリダーゼの機構解明と共有結合阻害剤の開発 (2014)
  • Author(s): 清田洋正、Christopher J. Vavricka、田中皓祐、Nongluk Sriwilaijaroen、佐藤宏樹、鈴木康夫、桑原重文、須原義智、大類洋、George F. Gao
  • Organizer: 第29回農薬デザイン研究会
  • Place of Presentation: 熱海
  • Year and Date: 2014-11-06
• [Presentation] 二フッ化シアル酸：インフルエンザ・シアリダーゼの機構解明と共有結合阻害剤の開発 (2014)
  • Author(s): 清田洋正、Christopher J. Vavricka、田中皓祐、Nongluk Sriwilaijaroen、佐藤宏樹、鈴木康夫、桑原重文、須原義智、大類洋、George F. Gao
  • Organizer: 第56回天然有機化合物討論会
  • Place of Presentation: 高知
  • Year and Date: 2014-10-15
• [Presentation] 抗腫瘍物質マオエクリスタルVの合成研究 (2014)
  • Author(s): 清田洋正、佐藤恵理子、小竹正晃、佐々木郁香、浅尾洋樹、島崎泰治、山田てい子、桑原重文
  • Organizer: 日本農芸化学会2014年度中四国支部大会
  • Place of Presentation: 徳島
  • Year and Date: 2014-09-27
• [Presentation] Synthetic Studies of Enacyloxin IIa (2014)
  • Author(s): Wataru Igarashi, Aki Saito, Hiroyuki Furukawa, HIroaki Hoshikawa, Teiko Yamada, Shigefumi Kuwahara, Hiromasa Kiyota
  • Organizer: Tohoku University Campus Asia Summer School 2013
  • Place of Presentation: 仙台
  • Year and Date: 2014-08-25
• [Presentation] Synthetic Studies of Maoecrystal V (2014)
  • Author(s): Hiromasa Kiyota, Eriko Sato, Masaaki Kotake, Hiroki Asao, Ayaka Sasaki, Masaharu Shimasaki, Shigefumi Kuwahara
  • Organizer: Tohoku University Campus Asia Summer School 2013
  • Place of Presentation: 仙台
  • Year and Date: 2014-08-25
• [Presentation] 抗生物質Enacyloxin IIaの合成研究 (2014)
  • Author(s): 清田洋正、五十嵐渉、齋藤亜紀、古川博之、星川浩輝、山田てい子、桑原重文
  • Organizer: 日本農芸化学会中四国支部第39回講演会
  • Place of Presentation: 福山
  • Year and Date: 2014-05-31
• [Presentation] 生物活性物質の合成化学的研究～農芸化学における合成化学の役割～ (2014)
  • Author(s): 清田洋正
  • Organizer: 日本農芸化学会創立90周年記念第17回中四国支部若手シンポジウム
  • Place of Presentation: 岡山
  • Year and Date: 2014-05-17
  • Invited
• [Presentation] 抗生物質Enacyloxin類の合成研究 (2014)
  • Author(s): 清田洋正
  • Organizer: 第4回有機分子構築法夏の勉強会
  • Place of Presentation: 湯河原
  • Year and Date: 2014-05-10
  • Invited
• [Presentation] Synthetic studies of clionamines, autophagy-modulating amino steroids isolated from Cliona celata
  • Author(s): Akiyuki Yoshida, Yuuki Sato, Konosuke Hiramatsu, Teiko Yamada, Shigefumi Kuwahara, Hiromasa Kiyota
  • Organizer: Tohoku University Campus Asia Summer School 2013
  • Place of Presentation: 仙台
• [Presentation] Synthetic Studies of Maoecrystal V
  • Author(s): Hiromasa Kiyota, Masaaki Kotake, Hiroki Asao, Ayaka Sasaki, Masaharu Shimasaki, Shigefumi Kuwahara
  • Organizer: 13th International Coference on the Chemistry of Antibiotics and Other Bioactive Compounds (ICCA-13)
  • Place of Presentation: 山中湖
• [Presentation] Synthetic studies of clionamines, autophgy-modulating amino steroids isolated from Cliona celata
  • Author(s): Akiyuki Yoshida, Yuuki Sato, Konosuke Hiramatsu, Teiko Yamada, Shigefumi Kuwahara, and Hiromasa Kiyota
  • Organizer: Tohoku University Campus Asia Summer School 2013
  • Place of Presentation: 仙台
• [Presentation] Synthetic Studies of Maoecrystal V
  • Author(s): Hiromasa Kiyota, Masaaki Kotake, Hiroki Asao, Ayaka Sasaki, Masaharu Shimasaki, Shigefumi Kuwahara
  • Organizer: nternational Symposium for the 70th Anniversary of the Tohoku Branch of the Chemical Society of Japan
  • Place of Presentation: 仙台
• [Presentation] Synthetic studies of enacyloxins (1): C9'-C23' fragment
  • Author(s): Wataru Igarashi, Hiroyuki Furukawa, Hiroaki Hoshikawa, Aki Saito, Manabu Yaosaka, Teiko Yamada, Shigefumi Kuwahara and Hiromasa Kiyota
  • Organizer: nternational Symposium for the 70th Anniversary of the Tohoku Branch of the Chemical Society of Japan
  • Place of Presentation: 仙台
• [Presentation] Synthetic studies of enacyloxins (2): C1-C6 and C1'-C15' fragments
  • Author(s): Aki Saito, Wataru Igarashi, Osamu Nakayama, Hiroyuki Furukawa, Hiroaki Hoshikawa, Teiko Yamada, Shigefumi Kuwahara and Hiromasa Kiyota
  • Organizer: nternational Symposium for the 70th Anniversary of the Tohoku Branch of the Chemical Society of Japan
  • Place of Presentation: 仙台
• [Presentation] 生物活性物質の合成化学的研究
  • Author(s): 清田洋正
  • Organizer: 第138回農芸化学特別セミナー
  • Place of Presentation: 岡山
  • Invited
• [Presentation] 抗生物質Enacyloxin IIaの合成研究
  • Author(s): 五十嵐渉、齋藤亜紀、古川博之、山田てい子、桑原重文、清田洋正
  • Organizer: 第28回農薬デザイン研究会
  • Place of Presentation: 京都
• [Presentation] におい物質の化学
  • Author(s): 清田洋正
  • Organizer: 日本農芸化学会東北支部平成25年度市民フォーラム
  • Place of Presentation: 山形
  • Invited
• [Presentation] 生物活性を有する天然低分子有機化合物の合成化学的研究
  • Author(s): 清田洋正
  • Organizer: 第21回大阪電気通信大学エレクトロニクス基礎研究所シンポジウム
  • Place of Presentation: 大阪
  • Invited
• [Presentation] 抗生物質エナシロキシン類の合成研究
  • Author(s): 清田洋正、五十嵐渉、齋藤亜紀、古川博之、星川浩輝、八尾坂学、山田てい子、桑原重文
  • Organizer: 日本農薬学会第39回大会
  • Place of Presentation: 京都
• [Presentation] 抗腫瘍物質マオエクリスタルVの合成研究
  • Author(s): 佐藤恵理子、小竹正晃、佐々木郁香、浅尾洋樹、島崎泰治、山田てい子、桑原重文、清田洋正
  • Organizer: 日本農芸化学会2014年度大会
  • Place of Presentation: 川崎
• [Presentation] 抗生物質エナシロキシン類の合成研究
  • Author(s): 清田洋正
  • Organizer: 第4回有機分子構築夏の勉強会
  • Place of Presentation: 湯河原
  • Invited
• [Remarks] 岡山大学大学院環境生命科学研究科 天然物有機化学研究室
  • URL: http://www.gels.okayama-u.ac.jp/profile/kouza/areas01_biochem.html
• [Remarks] 岡山大学農学部 天然物有機化学研究室
  • URL: http://www.okayama-u.ac.jp/user/agr/profile/nougaku01_1.html
• [Remarks] 東北大学農学部 生物有機科学研究室（清田グループ）
  • URL: http://www.agri.tohoku.ac.jp/yuuki/00kiyo/20kiyota.html
• [Remarks] 清田洋正
  • URL: http://www.agri.tohoku.ac.jp/yuuki/00kiyo/20kiyota.html