| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
Synthetic studies on natural products, which could be new drugs against drug-resistant strains, were carried out. About a sesquiterpene, which is a potent inhibitor of H. pylori growth, we examined optimization of racemic synthesis and synthesis of a substrate for optical resolution employing our tandem radical cyclization strategy. Concerning glabramycins, which are potent inhibitor against Staphylococcus aureus, we succeeded Structural revision of glabramycin B was achieved by enantioselective synthesis of our proposed structure. We also suggest the absolute configuration of Majusculoic acid, a novel antifungal drug, by synthesis of enantiomer of the natural product, although some problems in several steps have been still remained.
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