Synthetic and structural studies of natural antibiotics which have potent activities against drug resistance strains
| Project/Area Number |
25450147
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Bioorganic chemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
ISHIGAMI Ken 東京大学, 農学生命科学研究科, 准教授 (70292787)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 有機化学 / 天然物化学 / 立体化学 / 抗菌活性 / 薬剤耐性 / glabramycin / Majusculoic acid / 抗ピロリ菌 / Glabramycin / 抗菌物質 / 天然有機化合物 / 有機合成 / セスキテルペン / 絶対立体配置 |
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| Outline of Final Research Achievements |
Synthetic studies on natural products, which could be new drugs against drug-resistant strains, were carried out. About a sesquiterpene, which is a potent inhibitor of H. pylori growth, we examined optimization of racemic synthesis and synthesis of a substrate for optical resolution employing our tandem radical cyclization strategy. Concerning glabramycins, which are potent inhibitor against Staphylococcus aureus, we succeeded Structural revision of glabramycin B was achieved by enantioselective synthesis of our proposed structure. We also suggest the absolute configuration of Majusculoic acid, a novel antifungal drug, by synthesis of enantiomer of the natural product, although some problems in several steps have been still remained.
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] キラリティーを有する天然生理活性物質の合成研究.2015
Author(s)
K. Ishigami,T. Kato, S. Wakamori, H. Kageji, H. Watanabe
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Journal Title
Annual Report 2014 (Cryogenic Research Center, The University of Tokyo)
Volume: 6
Pages: 39-44
NAID
Related Report
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[Presentation] Total Synthesis of Glabramycin B.2015
Author(s)
M. Yamamoto, K. Ishigami, H. Watanabe
Organizer
The 13th International Kyoto Conference on New Aspects of Organic Chemistry (IKCOC-13)
Place of Presentation
リーガロイヤルホテル京都（京都府・京都市）
Year and Date
2015-11-09
Related Report
Int'l Joint Research
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[Presentation] Total Synthesis of (+)-Clavigerin B.2015
Author(s)
N. Kakimoto, K. Ishigami, H. Watanabe
Organizer
The 13th International Kyoto Conference on New Aspects of Organic Chemistry (IKCOC-13)
Place of Presentation
リーガロイヤルホテル京都（京都府・京都市）
Year and Date
2015-11-09
Related Report
Int'l Joint Research
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