| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
In this study, we explored two issues for the synthesis of nitrogen-containing polycyclic natural products: 1) stereoselective synthesis of 3,3-disubstituted oxindoles having a C3-quaternary stereogenic center via a chiral ortho-azaxylylene intermediate, and 2) catalytic asymmetric synthesis of N-aryl isatin. Our result allows us to synthesize a wide variety of oxindoles having substituents which can be seen in polycyclic alkaloids.
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