Stereocontrolled Synthesis of nitrogen-containing polycyclic scaffolds using axially chiral ortho-azaxylylene intermediate
Project/Area Number |
25450151
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Bioorganic chemistry
|
Research Institution | Nagoya University |
Principal Investigator |
NAKAZAKI Atsuo 名古屋大学, 生命農学研究科, 准教授 (00366428)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | ortho-アザキシリレン / 含窒素化合物 / 不斉合成 / 立体制御 / 3,3-二置換オキシインドール / 軸不斉 |
Outline of Final Research Achievements |
In this study, we explored two issues for the synthesis of nitrogen-containing polycyclic natural products: 1) stereoselective synthesis of 3,3-disubstituted oxindoles having a C3-quaternary stereogenic center via a chiral ortho-azaxylylene intermediate, and 2) catalytic asymmetric synthesis of N-aryl isatin. Our result allows us to synthesize a wide variety of oxindoles having substituents which can be seen in polycyclic alkaloids.
|
Report
(4 results)
Research Products
(50 results)
-
-
-
-
-
[Journal Article] Multimodal Biopanning of T7 Phage-displayed Peptide Reveals Angiomotin as a Potential Receptor of an Anti-angiogenic Macrolide Roxithromycin2015
Author(s)
Takakusagi, K.; Takakusagi, Y.; Suzuki, T. Toizaki, A.; Suzuki, A.; Kawakatsu, Y.; Watanabe, M.; Saito, Y.; Fukuda, R.; Nakazaki, A.; Kobayashi, S.; Sakaguchi, K.; Sugawara, F.
-
Journal Title
Eur. J. Med. Chem.
Volume: 90
Pages: 809-821
DOI
Related Report
Peer Reviewed
-
-
-
-
[Journal Article] Structural Study on a Naturally Occurring Terphenyl Quinone2013
Author(s)
Nakazaki, A.; Huang, W.-Y.; Koga, K.; Yingyongnarongkul, B.; Boonsombat, J.; Sawayama, Y.; Tsujimoto, T.; Nishikawa, T.
-
Journal Title
Bioscience, Biotechnology, and Biochemistry
Volume: 77
Issue: 7
Pages: 1529-1532
DOI
NAID
ISSN
0916-8451, 1347-6947
Related Report
Peer Reviewed
-
-
-
-
-
-
[Presentation] Synthesis of biologically active steroid-derived compounds from an edible mushroom2015
Author(s)
Toshio Nishikawa, Yoshiki Nakane, Atsuo Nakazaki, Takuya Imazu, Shouta Tokoro, Ryo Sakakibara, Masaatsu Adachi, Keiichi Konoki, Mari Yotsu-Yamashita
Organizer
The International Chemical Congress of Pacific Basin Societies 2015 (Pacifichem 2015)
Place of Presentation
Honolulu, Hawaii, USA
Year and Date
2015-12-15
Related Report
-
[Presentation] Synthesis and biological activities of guanidine-containing natural products2015
Author(s)
Toshio Nishikawa, Yoshiki Nakane, Atsuo Nakazaki, Takuya Imazu, Shouta Tokoro, Ryo Sakakibara, Masaatsu Adachi, Keiichi Konoki, Mari Yotsu-Yamashita
Organizer
The International Chemical Congress of Pacific Basin Societies 2015 (Pacifichem 2015)
Place of Presentation
Honolulu, Hawaii, USA
Year and Date
2015-12-15
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] Synthesis of Marine Toxins Aiming at Developing Ion-Channel Inhibitors2013
Author(s)
Toshio Nishikawa, Masaatsu Adachi, Ryo Sakakibara, Takuya Imazu, Yoshiki Satake, Shouta Tokoro, Atsuo Nakazaki, Yuuki Ishikawa, Yusuke Sawayama, Minoru Isobe, Keiichi Konoki, Yukie Chiba, Mari Yotsu-Yamashita
Organizer
The 2nd International Symposium on Chemical Biology of Natural Products: Target ID and Regulation of Bioactivity
Place of Presentation
Yokohama
Related Report
-
-
-
-
-
[Presentation] Synthetic Studies on Sespendole
Author(s)
Keiko Higuchi, Nopporn Thasana, Kumi Sugino, Atsuo Nakazaki, Masaatsu Adachi, Toshio Nishikawa
Organizer
名古屋大学博士課程教育リーディングプログラムリーディングプログラム 成果報告会
Place of Presentation
名古屋
Related Report
-
-
-
-
[Presentation] Synthetic Studies on Sespendole
Author(s)
Keiko Higuchi, Nopporn Thasana, Kumi Sugino, Atsuo Nakazaki, Masaatsu Adachi, Toshio Nishikawa
Organizer
Thieme Chemistry - Nagoya Symposium 2013
Place of Presentation
Nagoya
Related Report