Exploitation of caloric restriction mimetics from rare sugars and their deoxy derivatives
| Project/Area Number |
25450156
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Bioorganic chemistry
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| Research Institution | Kagawa University |
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Principal Investigator |
Sato Masashi 香川大学, 農学部, 教授 (20263890)
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIHARA AKIHIDE 香川大学, 農学部, 助教 (40548765)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 希少糖 / カロリー制限模倣物質 / 抗老化 / 線虫 / カロリー制限 / 寿命延長 |
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| Outline of Final Research Achievements |
The aim of this study is to explore calorie restriction mimetics (CRM) from deoxy derivatives of monosaccharides (deoxy rare sugars). We enzymatically synthesized various deoxy rare sugars including 1- and 6-deoxy derivatives of ketohexoses, and 6-deoxy derivatives of aldohexoses. These deoxy rare sugars were subjected to preliminary screening by evaluating growth inhibition activity against the nematode Caenorhabditis elegans. As a result, a deoxy rare sugar exerted strong inhibition activity. The deoxy rare sugar also extended C. elegans lifespan. These results indicate that the deoxy rare sugar is a candidate CRM.
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Report
(4 results)
Research Products
(13 results)
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[Presentation] The rare sugar D-psicose extends Caenorhabditis elegans lifespan by increasing oxidative stress resistance
Author(s)
Sato, M., Sakoguchi, H., Shintani, T., Okuma, K., and Izumori, K.
Organizer
19th International C. elegans Meeting 2013
Place of Presentation
UCLA, CA, USA
Related Report
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