| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Outline of Final Research Achievements |
The aim of this study is to explore calorie restriction mimetics (CRM) from deoxy derivatives of monosaccharides (deoxy rare sugars). We enzymatically synthesized various deoxy rare sugars including 1- and 6-deoxy derivatives of ketohexoses, and 6-deoxy derivatives of aldohexoses. These deoxy rare sugars were subjected to preliminary screening by evaluating growth inhibition activity against the nematode Caenorhabditis elegans. As a result, a deoxy rare sugar exerted strong inhibition activity. The deoxy rare sugar also extended C. elegans lifespan. These results indicate that the deoxy rare sugar is a candidate CRM.
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