| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Outline of Final Research Achievements |
It is unclear how postprandial GLP-1 secretory response is affected during the development of diet-induced obesity. Meal tolerance test (MTT) was conducted in rats fed normal or high-fat/high-sucrose (HF/HS) diet, and postprandial GLP-1, insulin and glycemic response were monitored.
Postprandial GLP-1 secretion was larger in HF/HS rats than control rats at week 2 and 4, and this was reflected by increased insulin response in HF/HS rats. In the intestinal mucosa, among various nutrient sensing receptors and transporters evaluated, one of fatty acid receptors, FFAR1 had higher mRNA expression in the upper small intestine of HF/HS rats compared to that of control rats.
These result demonstrates that postprandial GLP-1 secretion is increased in the early period of developing diet-induced obesity, and that increased postprandial GLP-1 response contributes to normalize postprandial glycemic response by enhancing insulin secretion.
|
