| Project/Area Number |
25450160
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Kitami Institute of Technology |
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Principal Investigator |
ARAI HIROFUMI 北見工業大学, 工学部, 准教授 (70295848)
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| Co-Investigator(Kenkyū-buntansha) |
YAMADA Koji 崇城大学, 生物生命学部, 教授 (60158186)
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| Co-Investigator(Renkei-kenkyūsha) |
YAMAGISHI Takashi 北見工業大学, 工学部, 特任教授 (80271758)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | アレルギー / ポリフェノール / タンニン / テリマグランジン / ヒスタミン / ロイコトリエン / マスト細胞 |
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| Outline of Final Research Achievements |
It is known that about 30% of Japanese people have any allergy diseases. Immediate hypersensitivity such as hay fever is induced by mast cells which are stimulated through the antigen-antibody reaction. In the present study, we investigated effects of hydrolyzable tannins in Rugosa rose petals on the allergic reaction in mast cells using cell lines.
Tellimagrandin I, a kind of hydrolyzable tannin in Rugosa rose petals, suppressed the chemical mediator release from the stimulated mast cells. Moreover, tellimagrandin I inhibited the phosphorylation of protein kinases and calcium influx in mast cells. These results suggest that tellimagrandin I may have the anti-allergic function.
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