Study on mechanism for anti-allergic effect of hydrolyzable tannin in rugosa rose petals

• Project/Area Number: 25450160
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Food science
• Research Institution: Kitami Institute of Technology
• Principal Investigator: ARAI HIROFUMI 北見工業大学, 工学部, 准教授 (70295848)
• Co-Investigator(Kenkyū-buntansha): YAMADA Koji 崇城大学, 生物生命学部, 教授 (60158186)
• Co-Investigator(Renkei-kenkyūsha): YAMAGISHI Takashi 北見工業大学, 工学部, 特任教授 (80271758)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: アレルギー / ポリフェノール / タンニン / テリマグランジン / ヒスタミン / ロイコトリエン / マスト細胞

Outline of Final Research Achievements

It is known that about 30% of Japanese people have any allergy diseases. Immediate hypersensitivity such as hay fever is induced by mast cells which are stimulated through the antigen-antibody reaction. In the present study, we investigated effects of hydrolyzable tannins in Rugosa rose petals on the allergic reaction in mast cells using cell lines.
Tellimagrandin I, a kind of hydrolyzable tannin in Rugosa rose petals, suppressed the chemical mediator release from the stimulated mast cells. Moreover, tellimagrandin I inhibited the phosphorylation of protein kinases and calcium influx in mast cells. These results suggest that tellimagrandin I may have the anti-allergic function.

Research Products

• [Presentation] テリマグランジンによるアレルギー抑制作用 (2015)
  • Author(s): 新井博文
  • Organizer: 日本健康医学会
  • Place of Presentation: 愛知県長久手市
  • Year and Date: 2015-11-21
• [Presentation] Inhibitory effect of tellimagrandin I in Rosa rugosa petals on allergic reaction (2013)
  • Author(s): Arai, H., Takaya, Y., Sasayama, S., Toda, K., Takahashi, R., Yamagishi, T., Utsunomiya, A., Hosomi, R., Fukunaga, K., and Takasugi, M.
  • Organizer: American Oil Chemists' Society
  • Place of Presentation: Palais des congres de Montreal（カナダ、モントリール市）
• [Presentation] ハマナス花弁由来加水分解性タンニンによるアレルギー抑制作用 (2013)
  • Author(s): 新井博文, 高谷祐介, 笹山志穂, 戸田一也, 高橋良輔, 山岸喬, 宇都宮紋, 高杉美佳子
  • Organizer: 日本栄養・食糧学会
  • Place of Presentation: 名古屋大学（愛知県名古屋市）