Analysis of a novel lipid metabolism-related gene derived from high-fat diet induced fatty liver mouse.
| Project/Area Number |
25450166
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
HORIO FUMIHIKO 名古屋大学, 大学院生命農学研究科, 教授 (20165591)
MURAI ATSUSHI 名古屋大学, 大学院生命農学研究科, 准教授 (10313975)
ODA HIROAKI 名古屋大学, 大学院生命農学研究科, 准教授 (20204208)
OHNO TAMIO 名古屋大学, 大学院医学系研究科, 准教授 (90293620)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 脂肪肝 / 高脂肪食 / ノックアウト / 遺伝解析 / 脂質代謝 / ノックアウトマウス / 候補遺伝子 / モデルマウス / 食餌誘導性 |
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| Outline of Final Research Achievements |
We previously identified fatty liver susceptible locus (Fl1sa) on mouse chromosome 12 in SMXA-5 mice, a model of high-fat induced fatty liver. We selected Iah1 gene as a candidate gene for Fl1sa. To clarify the relation between Iah1 gene and fatty liver, we constructed the Iah1 gene knockout mice. Liver lipids contents in Iah1 gene knockout mice were lower than that in WT mice. This study suggested that the low expression level of Iah1 led to the accumulation of lipids in liver.
In addition, we found that mice having the large insertion/deletion in upstream of Iah1 gene showed low level of Iah1 gene expression.
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Report
(5 results)
Research Products
(17 results)
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[Journal Article] Searching for genomic region of high-fat diet-induced type 2 diabetes in mouse chromosome 2 by analysis of congenic strains2014
Author(s)
4.Kobayashi M, Ohno T, Ihara K, Murai, A., Kumazawa, M., Hoshino, H., Iwanaga, K., Iwai, H., Hamana, Y., Ito, M., Ohno, K., Horio, M..
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Journal Title
Plos One
Volume: 9
Issue: 5
Pages: e96271-e96271
DOI
Related Report
Peer Reviewed / Open Access
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