| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Outline of Final Research Achievements |
Japanese rice wine (Sake)-derived pyroglutamyl peptides have anti-inflammatory effect on dextran sulfate sodium (DSS)-induced acute colitis in mice. We found out the optimal fermented condition according as amazake, a traditional sweet, low- or non-alcohol Japanese drink made from fermented rice. Amazake like sample showed greater anti-inflammatory effect than individual pyroglutamyl peptides. Pyroglutamyl peptides also improved microbiota in this model. In human trial, oral administration of amazake like sample did not show any adverse reaction, and improved fecal microbiota in irritable bowel syndrome. This result indicates that pyroglutamyl peptides might be one of health-promoting component in Japanese traditional fermented foods.
|
