Elucidation of in vivo kineticus and clearance mechanism on dietary oxidized cholesterol
| Project/Area Number |
25450183
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Meiji University |
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Principal Investigator |
Osada Kyoichi 明治大学, 農学部, 専任教授 (30271795)
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| Research Collaborator |
TERUNUMA Schoichiro
SEKIHARA Hanae
OGAWA Eriko
HOSONO Yukiko
Kato Satoshi
OTANI Sachiho
YUI Kazuki
KAWAKAMI Yuki
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 酸化コレステロール / 脂質代謝 / 加工食品 / クリアランス / 蓄積 / ラット / 代謝 / 7-ketocholesterol / 7beta-hydroxycholesterol / コレステロール / リポ蛋白質 |
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| Outline of Final Research Achievements |
Dietary oxidized cholesterol was incorporated into lipoprotein as well as cholesterol and transported to peripheral tissues. 7-Ketocholesterol related to various diseases may be difficult to be metabolized with age. Therefore, the modulation in metabolism of 7-ketocholesterol may be related to the onset of a disease with an increased risk of developing with age.
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Report
(5 results)
Research Products
(14 results)
