Approaches to enhancement of mucosal immunity based on control of gut-type dendritic cells with retinoic acid-producing capacity
Project/Area Number |
25450190
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Food science
|
Research Institution | Tokushima Bunri University |
Principal Investigator |
NAKATSUMA Aya 徳島文理大学, 薬学部, 助教 (30446075)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | ビタミンA / レチノイン酸 / 粘膜免疫 / 樹状細胞 / T細胞 / 免疫寛容 / アレルギー / 炎症 |
Outline of Final Research Achievements |
GM-CSF induced retinal dehydrogenase 2 (RALDH2) and CD103 expression in bone marrow-derived dendritic cells (DCs) in the presence of retinoic acid, an active vitamin A metabolite. Subsequent activation of integrin β1 signaling enhanced DC maturation and RALDH2 expression without inducing inflammatory cytokines. The RALDH2+CD103+ DCs efficiently induced gut-tropic Foxp3+ inducible regulatory T cells and alleviated dextran sulfate sodium-induced murine colitis. Vitamin A deficiency directed intestinal epithelial cells to produce TNF-α that enhanced an ability of DCs to induce inflammatory T cells. These results suggest that retinoic acid inhibits allergic responses to oral antigens by preventing intestinal DCs from inducing inflammatory T cells.
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Report
(4 results)
Research Products
(23 results)