The effect of food ingredients on central nervous system.

• Project/Area Number: 25450192
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Food science
• Research Institution: Kinki University
• Principal Investigator: OHNUKI Koichiro 近畿大学, 工学部, 准教授 (50378668)
• Co-Investigator(Kenkyū-buntansha): SHIMIZU Kuniyoshi 九州大学, 農学研究院, 准教授 (20346836)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 精神機能 / 機能性食品 / 動物行動 / 生理心理 / マウス / 香り / ヤマブシタケ

Outline of Final Research Achievements

The aim of this project is to establish the comprehensive screening system which brings to discover substances with mental function to support healthy brain function and mental clarity, and to prevent and improve stress-induced mental diseases in modern society. We found that Hericium erinaceus decreased anxiety in mice using the comprehensive screening system. We also found that some kind of volatile compounds improve stress. These results suggest that the comprehensive screening system is useful for develop functional foods.

Research Products

• [Journal Article] Inhibition of neuraminidase by Ganoderma triterpenoids and implications for neuraminidase inhibitor design. (2015)
  • Author(s): Zhu Q, Bang TH, Ohnuki K, Sawai T, Sawai K, Shimizu K.
  • Journal Title: Sci Rep. Volume: 5 Issue: 1 Pages: 13194-13202
  • DOI: 10.1038/srep13194
  • Peer Reviewed / Open Access
• [Journal Article] Inhibitory effects of the leaves of loquat (Eriobotrya japonica) on bone mineral density loss in ovariectomized mice and osteoclast differentiation. (2014)
  • Author(s): Tan H, Furuta S, Nagata T, Ohnuki K, Akasaka T, Shirouchi B, Sato M, Kondo R, Shimizu K.
  • Journal Title: J Agric Food Chem. Volume: 62(4) Issue: 4 Pages: 836-41
  • DOI: 10.1021/jf402735u
  • Peer Reviewed
• [Journal Article] Biological activities and phytochemical profiles of extracts from different parts of bamboo (Phyllostachys pubescens) (2014)
  • Author(s): Akinobu Tanaka, Qinchang Zhu, Hui Tan, Hiroki Horiba, Koichiro Ohnuki, Yasuhiro Mori,Ryoko Yamaguchi, Hiroya Ishikawa, Akira Iwamoto, Hiroharu Kawahara, Kuniyoshi Shimizu
  • Journal Title: Molecules Volume: 19 Issue: 6 Pages: 8238-8260
  • DOI: 10.3390/molecules19068238
  • Peer Reviewed / Open Access
• [Journal Article] Effect of Dietary Fat Type on Anxiety-Like and Depression-Like Behavior in Mice (2013)
  • Author(s): Wataru Mizunoya, Koichiro Ohnuki, Kento Baba, Hideo Miyahara, Naomi Shimizu, Kuniko Tabata, Takako Kino, Yusuke Sato, Ryuichi A Tatsumi, Yoshihide Ikeuchi
  • Journal Title: SpringerPlus Volume: 2 Issue: 1 Pages: 165-165
  • DOI: 10.1186/2193-1801-2-165
  • Peer Reviewed
• [Presentation] ガンマ線照射と電子線照射の脂質への影響の比較 (2015)
  • Author(s): 南育子、中川敏法、海渕覚、岸川明日香、堀場大生、大貫宏一郎、清水邦義、等々力節子
  • Organizer: 第51回日本食品照射研究協議会
  • Place of Presentation: 東京都立産業技術研究センター（東京都江東区）
  • Year and Date: 2015-11-20
• [Presentation] ‘Kuromatu’ (Pinus thunbergii) and ‘Yusuge’ (Hemerocallis vespertina H.Hara) extracts inhibit pancreatic lipase activity in vitro (2015)
  • Author(s): Koba Y, Hiraki E, Nakagawa T, Shimizu K, Ohnuki K
  • Organizer: Joint International Symposium on「Regional Revitalization and Innovation for Social Contribution」 and and「e-ASIA Functional Materials and Biomass Utilization 2015」
  • Place of Presentation: 福岡県立大学（福岡県田川市）
  • Year and Date: 2015-10-30
  • Int'l Joint Research
• [Presentation] 木質空間に使用される素材の違いが室内の各種環境要素に及ぼす影響 －雨季の物理・化学的環境要素に着目した検討－ (2015)
  • Author(s): 奥田拓、鷲岡ゆき、長池淳、吉村友里、井隼経子、藤田弘毅、川﨑章惠、佐藤宣子、藤本登留、清水邦義岡本剛、山田祐樹、永野純、石川洋哉、大貫宏一郎、井上伸史、渡邉雄一郎、嶋津久憲、安成信次
  • Organizer: 第２２回日本木材学会九州支部大会
  • Place of Presentation: ホルトホール大分（大分県大分市）
  • Year and Date: 2015-10-05
• [Presentation] 植物抽出物によるリパーゼ阻害効果の評価 (2015)
  • Author(s): 古場有里恵、平木絵里、中川敏法、清水邦義、大貫宏一郎
  • Organizer: 日本化学会九州支部設立100周年記念国際シンポジウム 第５２回化学関連支部合同九州大会
  • Place of Presentation: 北九州国際会議場（福岡県北九州市）
  • Year and Date: 2015-06-27
• [Presentation] 「無垢材」と「新建材」を使った居住空間におけるヒトの生理心理学的分析 (2014)
  • Author(s): 長池淳、松本清、山本篤、福田竜大、山邉結子、照井佳世、吉村友里、中川敏法、藤田弘毅、川﨑章惠、佐藤宣子、藤本登留、清水邦義、岡本剛、山田祐樹、永野純、光藤崇子、大貫宏一郎、石川洋哉、中島大輔、安成信次、嶋津久憲、渡邉雄一郎、井上伸史
  • Organizer: 第21 回日本木材学会九州支部大会
  • Place of Presentation: くまもと県民交流館（熊本市）
  • Year and Date: 2014-09-12
• [Presentation] 屋久杉（地杉）の精油および各種副産物における機能性探索 (2014)
  • Author(s): 中川敏法、朱欽昌、清水邦義、石川洋哉、大貫宏一郎、柿野賢一、堀内直哉、篠塚宏明、内藤輝実、松本毅史、南沢典子、谷田貝光克
  • Organizer: 第21 回日本木材学会九州支部大会
  • Place of Presentation: くまもと県民交流館（熊本市）
  • Year and Date: 2014-09-11
• [Presentation] 乾燥方法の異なる徳島すぎ人工乾燥材における加熱脱着GC-MS法を用いた揮発性成分分析 (2014)
  • Author(s): 吉村友里、中川敏法、清水邦義、藤本登留、石川洋哉、大貫宏一郎、網田克明、橋本茂、和田善行
  • Organizer: 第21 回日本木材学会九州支部大会
  • Place of Presentation: くまもと県民交流館（熊本市）
  • Year and Date: 2014-09-11
• [Presentation] Resveratrol and its dimers down-regulate protein S mRNA expression in HepG2 cells. (2013)
  • Author(s): Hiroko Tsuda, Eri Nakazono , Shihoko Sata, Akinobu Kishi, Taiji Matsukawa, Koichiro Ohnuki
  • Organizer: ISTH
  • Place of Presentation: Amsterdam, The Netherland
• [Presentation] Restorative effect of wooden materials on electrophysiological responses in humans. (2013)
  • Author(s): Sayaka Matsumoto, Tsuyoshi Okamoto, Atsushi. Yamamoto, K Ohnuki, Kuniyoshi Shimizu:
  • Organizer: Society for Neuroscience
  • Place of Presentation: San Diego, California, USA