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Molecular mechanism of the defense systems against host immunity by causative bacillus of Edwardsiellosis in fishes - Cell biological approach -

Research Project

Project/Area Number 25450304
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Aquatic life science
Research InstitutionNagasaki University

Principal Investigator

OSATOMI Kiyoshi  長崎大学, 水産・環境科学総合研究科(水産), 教授 (40253702)

Co-Investigator(Kenkyū-buntansha) HARA Kenji  長崎大学, 水産・環境科学総合研究科(水産), 教授 (10039737)
KANAI Kinya  長崎大学, 水産・環境科学総合研究科(水産), 教授 (40145222)
ODA Tatsuya  長崎大学, 水産・環境科学総合研究科(水産), 教授 (60145307)
YOSHIDA Asami  長崎大学, 水産・環境科学総合研究科(水産), 准教授 (80589870)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywordsflagellin / 抗酸化酵素 / プロモーター / 魚病細菌 / 酸化ストレス / 細胞培養系
Outline of Final Research Achievements

In this study, we examined the effects of extracellular products (ECP) from Edwardsiella tarda (E.tarda) strains and recombinant flagellin from virulent strain of E.tarda on macrophages in terms of the induction of TNF-α and NO. Notably, recombinant flagellin from virulent strain of E.tarda stimulated macrophages to induce TNF-α production. From the deletion analysis of the SOD1 promoter, it was suggested that NF-IL6 binding site was the regulatory element of SOD1 against the oxidative stress.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (4 results)

All 2015 2014 Other

All Presentation (4 results)

  • [Presentation] Edwardsiella tarda由来組換えflagellin暴露に伴うマクロファージ系細胞株の応答2015

    • Author(s)
      前田 大輝
    • Organizer
      平成27年度日本水産学会秋季大会
    • Place of Presentation
      東北大学(仙台市青葉区)
    • Year and Date
      2015-09-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] ヒラメCu,Zn-SOD遺伝子プロモーター領域の解析2014

    • Author(s)
      石井 琢哉
    • Organizer
      平成26年度日本水産学会秋季大会
    • Place of Presentation
      九州大学 (福岡市東区)
    • Year and Date
      2014-09-20
    • Related Report
      2014 Research-status Report
  • [Presentation] ヒラメSOD遺伝子プロモーター領域の解析

    • Author(s)
      石井 琢哉
    • Organizer
      平成25年度日本水産学会秋季大会
    • Place of Presentation
      三重大学(三重県津市)
    • Related Report
      2013 Research-status Report
  • [Presentation] Edwardsiella tarda鞭毛構成タンパク質flagellinの構造解析

    • Author(s)
      東谷 福太郎
    • Organizer
      平成25年度日本水産学会秋季大会
    • Place of Presentation
      三重大学(三重県津市)
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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