Role of cell-mediated immunity in the protection against nocardiosis and mycobacteriosis in fish
| Project/Area Number |
25450305
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Aquatic life science
|
|---|
| Research Institution | Kagoshima University |
|---|
Principal Investigator |
Araki Kyosuke 鹿児島大学, 農水産獣医学域水産学系, 助教 (30409073)
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | ノカルジア症 / ミコバクテリア症 / 細胞性免疫 / ワクチン / ブリ / カンパチ / IL-12 / IFNgamma / Interleukin-12 / Interferon gamma / Interleukin-10 / 細胞内寄生細菌 / ミコバクテリウム症 / アジュバント / 結節 |
|---|
| Outline of Final Research Achievements |
In this project, we showed 1) interferon-γ and interleukin-12 which are related to the cell-mediated immunity, play a crucial role in the protection against Nocardia seriolae infection in amberjack, 2) interleukin-10 is related to induction of humoral immune response against Nocardia seriolae infection, 3) IL-12 is a promising adjuvant for inactivated vaccine against Nocardiosis in amberjack, 4) 6 kDa early secretory target (ESAT-6) and 10 kDa culture filtrate protein (CFP-10) from Mycobacterium sp. have a potential for the protective antigen against Mycobacterium sp. infection in fish.
|
Report
(4 results)
Research Products
(24 results)
-
-
-
-
[Journal Article] Serum GlucNAc-binding IgM of fugu (Takifugu rubripes) suppresses2013
Author(s)
Tsutsui, S., Ariji, T., Sato, A., Yoshida, T., Yamamura, N., Odaka, T., Araki, K., Suetake, H., Miyadai, T., Nakamura, O.
-
Journal Title
Dev. Comp. Immunol.
Volume: 41
Issue: 1
Pages: 20-26
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] N-acetyl-D-glucosamine-binding immunoglobulin M of fugu (Takifugu rubripes) inhibits the growth of fish pathogenic bacteria: A novel function of teleost antibody.2013
Author(s)
Tsuitsui, S., Ariji, T, Sato, A., Yoshida, T., Yamamura, N., Odaka, T., Araki, K., Suetake, H., Miyadai, T., Nakamura, O.
Organizer
First International Conference of Fish and Shellfish Immunology
Place of Presentation
Vigo, Spain
Related Report
-
[Presentation] Comparative analysis of adaptive immune response to live and inactivated Edwardsiella tarda in ginbuna crucian carp, Carassius auratus langsdorfii.2013
Author(s)
Yamasaki, M., Araki, K., Nakanishi, T., Nakayasu, C., Yamamoto, A.
Organizer
16th International Conference on Disease of Fish and Shellfish
Place of Presentation
Tampere, Finland
Related Report
-
[Presentation] Adaptive immune response in yellowtail Seriola quinqueradiata induced by formalin-killed Mycobacterium sp. in oil-adjuvant.2013
Author(s)
Araki, K., Shimono, Y., Yamasaki, M., Matsumoto, S., Yanagi, S., Maeno, K., Yamamoto, A.
Organizer
16th International Conference on Disease of Fish and Shellfish
Place of Presentation
Tampere, Finland
Related Report
-
-
-
