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Adaptive immune system in teleost peritoneal cavity

Research Project

Project/Area Number 25450307
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Aquatic life science
Research InstitutionFukui Prefectural University

Principal Investigator

SUETAKE Hiroaki  福井県立大学, 海洋生物資源学部, 准教授 (00334326)

Co-Investigator(Kenkyū-buntansha) MIYADAI Toshiaki  福井県立大学, 海洋生物資源学部, 教授 (20157663)
Research Collaborator ODAKA Tomoyuki  
SAITO Takumi  
MARUYAMA Ami  
CHUJO Taro  
MAEDA Tomoki  
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsワクチン / 免疫 / フグ / トラフグ / 養殖 / 免疫学 / 魚病
Outline of Final Research Achievements

Vaccination is one of the most effective ways to prevent fish diseases in aquaculture. The vaccination is based on adaptive immune system, but how the system is activated in the fish peritoneal cavity is still unknown.
First, we examined the composition of fugu peritoneal cavity leukocytes. The biggest population was B cells that produce antibody, and the second one was macrophages. Next, we cultured the peritoneal leukocytes with insoluble substance. Both macrophages and B cell took up the substance. At last, we demonstrated that the chemokine secreted from the peritoneal macrophages attracted the peritoneal B cells. Thus, interaction of B cells and macrophages in the fish peritoneal cavity play an important role in fish adaptive immune system.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (3 results)

All 2015 Other

All Presentation (3 results)

  • [Presentation] トラフグ腹腔マクロファージが産生するCXCL13はB細胞遊走を促進する2015

    • Author(s)
      小髙智之、齋藤匠、中条太郎、前田知己、末武弘章、宮台俊明
    • Organizer
      第27回日本比較免疫学会学術集会
    • Place of Presentation
      福井県小浜市
    • Year and Date
      2015-08-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] トラフグ腹腔B細胞はマクロファージの産生するCXCL13によって腹腔に集積する2015

    • Author(s)
      齋藤匠、小高智之、中条太郎、前田知己、末武弘章、宮台俊明
    • Organizer
      平成27年度日本水産学会春季大会
    • Place of Presentation
      東京海洋大学
    • Year and Date
      2015-03-27 – 2015-03-31
    • Related Report
      2014 Research-status Report
  • [Presentation] トラフグ腹腔B細胞の同定と機能解析

    • Author(s)
      齋藤匠、小高智之、末武弘章、前田知己、宮台俊明
    • Organizer
      第25回日本比較免疫学会学術集会
    • Place of Presentation
      岡山理科大学
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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